Background In the animal combined and Human study, we have previously found that treatment of 5-day increase the plasticity of cortical also facilitates brain – derived neurotrophic factor ( BDNF ) – receptor tyrosine kinase B (TrkB) signaling and increased activated TrkB and N-methyl-d-aspartate receptor (NMDAR) association in both the cortex and peripheral lymphocytes.

Patients with Parkinson’s disease (PD), in general, show decreased cortical plasticity, as shown by electrophysiological and behavioral studies. Here, we tested the hypothesis that exercise programs that improve motor function and appears to slow the progression of symptoms can improve BDNF -TrkB signals in lymphocytes. Methods A total of 16 patients with PD experience 4 -week intensive multidisciplinary rehabilitation treatment (MIRT), which includes aerobic exercise and physical and occupational therapy.

Blood was collected before and after 2 and 4 MIRT week. Lymphocytes isolated to check the BDNF -TrkB signaling caused by incubation with recombinant Human BDNF . TrkB signaling complex, extracellular-signal-regulated kinase-2 and protein-kinase-B immunoprecipitated; immunocomplexes contents determined by Western blotting. Results After MIRT, all patients showed improvements in motor function. TrkB interaction with NMDAR and BDNF -TrkB signaling increases in peripheral lymphocyte receptor, intracellular mediators, and the downstream level.

The decrements in the Unified Parkinson’s Disease Rating Scale II (UPDRSII) and total scores were significantly correlated with the increase in receptor TrkB signaling, intracellular mediators, and the level of interaction of NMDAR. Conclusion The significant correlation between reduced UPDRS score and change the activity of lymphocytes demonstrated that improved BDNF -TrkB signaling in lymphocytes and reduce the severity of symptoms of PD may be related.

Intensive Rehabilitation Enhances Lymphocyte BDNF-TrkB Signaling in Patients With Parkinson's Disease.
Intensive Rehabilitation Enhances Lymphocyte BDNF-TrkB Signaling in Patients With Parkinson’s Disease.

Late pulses like receptor 4 inversely attenuating the effects of Chinese herbal Xiao-Qing-Long-Tang on allergen-induced nerve growth factor and thymic stromal lymphopoietin.4

Xiao-Qing-Long-Tang (XQLT) is known to regulate the immune allergic reaction. The purpose of this study was to investigate the effects of XQLT on allergen-induced cytokine and related signaling pathways. A rat model of acute allergic used to investigate the effects of XQLT on nerve growth factor (NGF) during an allergic reaction, while Human pulmonary alveolar epithelial cells (HPAEpiCs) was used to investigate the effects of XQLT on Dermatophagoides pteronyssinus group 2 ( der p 2) -induced NGF, p75 neurotrophin receptor (p75NTR) and thymic stromal lymphopoietin (TSLP) expression. XQLT shown to inhibit allergic reactions associated NGF- and p75NTR in a mouse model.

XQLT also reduce the expression of Toll-like receptor 4 (TLR 4 ) in the lungs of rat models. XQLT inhibit Der p 2-induced NGF, TSLP and p75NTR expression in cell lines HPAEpiC. The use recombinant TLR soluble 4 (sTLR 4 ) in the competitive test XQLT partially attenuated inhibitory effect on NGF, TSLP and p75NTR expression in HPAEpiC cells. XQLT inhibitory effect on Ser536 phosphorylation of p65 (nuclear factor-kB; NF-kB), a TLR 4 the impact factor, is also attenuated by sTLR 4 .

Recombinant Human Neurotrophin-3 (NTF3)

RPC27838-1mg 1mg
EUR 6879.6

Recombinant Human Neurotrophin-3 (NTF3)

RPC27838-20ug 20ug
EUR 550

Recombinant Human Neurotrophin-3 (NTF3)

RPC28701-100ug 100ug
EUR 1170.4

Recombinant Human Neurotrophin-3 (NTF3)

RPC28701-1mg 1mg
EUR 3252

Recombinant Human Neurotrophin-3 (NTF3)

RPC28701-20ug 20ug
EUR 440

Human Neurotrophin 4 (NTF4) ELISA Kit

20-abx152512
  • EUR 7970.40
  • EUR 4250.40
  • EUR 990.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Neurotrophin 4 (NTF4) ELISA Kit

abx251825-96tests 96 tests
EUR 848.4

Human Neurotrophin 4 (NTF4) ELISA Kit

abx050177-96tests 96 tests
EUR 782.4

Human Neurotrophin 4 (NTF4) ELISA Kit

abx575476-96tests 96 tests
EUR 848.4

Neurotrophin 4 (NTF4) Antibody

abx235682-100ug 100 ug
EUR 577.2

Neurotrophin 4 (NTF4) Antibody

20-abx241784
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Neurotrophin 4 (NTF4) Antibody

20-abx110042
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Neurotrophin 4 (NTF4) Antibody

20-abx326456
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Neurotrophin 4 (NTF4) Antibody

20-abx114093
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Neurotrophin 4 (NTF4) Antibody

20-abx002282
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Neurotrophin 4 (NTF4) Antibody

20-abx001004
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Neurotrophin 4 (NTF4) Antibody

20-abx142109
  • EUR 444.00
  • EUR 727.20
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 50 ul

Neurotrophin 4 (NTF4) Antibody

abx145494-100ug 100 ug
EUR 469.2

Neurotrophin-4 (NTF4) Antibody

20-abx137025
  • EUR 427.20
  • EUR 627.60
  • 0.5 mg
  • 1 mg

Human NTF4/ Neurotrophin-4 ELISA Kit

E2816Hu 1 Kit
EUR 685.2

Neurotrophin 4 Antibody / NTF4

RQ5832 100 ug
EUR 356.15
Description: Neurotrophin-4 (NT-4), also known as neurotrophin-5 (NT-5), is a protein that in humans is encoded by the NTF4 gene. This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood.

Recombinant Human Neurotrophin-4

7-01303 2µg Ask for price

Recombinant Human Neurotrophin-4

7-01304 10µg Ask for price

Recombinant Human Neurotrophin-4

7-01305 1mg Ask for price

Rat Neurotrophin 4 (NTF4) ELISA Kit

abx255863-96tests 96 tests
EUR 848.4

Rat Neurotrophin 4 (NTF4) ELISA Kit

20-abx155889
  • EUR 8684.40
  • EUR 4626.00
  • EUR 1074.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Pig Neurotrophin 4 (NTF4) ELISA Kit

abx362091-96tests 96 tests
EUR 990

Rat Neurotrophin 4 (NTF4) ELISA Kit

abx050178-96tests 96 tests
EUR 782.4

Rat Neurotrophin 4 (NTF4) ELISA Kit

abx575477-96tests 96 tests
EUR 848.4

Mouse Neurotrophin 4 (NTF4) ELISA Kit

abx254300-96tests 96 tests
EUR 848.4

Mouse Neurotrophin 4 (NTF4) ELISA Kit

20-abx154459
  • EUR 7970.40
  • EUR 4250.40
  • EUR 990.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Sheep Neurotrophin 4 (NTF4) ELISA Kit

abx364700-96tests 96 tests
EUR 1111.2

Mouse Neurotrophin 4 (NTF4) ELISA Kit

abx050179-96tests 96 tests
EUR 782.4

Mouse Neurotrophin 4 (NTF4) ELISA Kit

abx574572-96tests 96 tests
EUR 848.4

Rabbit Neurotrophin 4 (NTF4) ELISA Kit

abx362259-96tests 96 tests
EUR 990

Monkey Neurotrophin 4 (NTF4) ELISA Kit

abx360359-96tests 96 tests
EUR 990

Chicken Neurotrophin 4 (NTF4) ELISA Kit

abx356910-96tests 96 tests
EUR 990

Recombinant Human NT-3/Neurotrophin-3/NTF3 Protein, No Tag

E40KMH1479 20ug
EUR 495

Rat Ntf4/ Neurotrophin-4 ELISA Kit

E0702Ra 1 Kit
EUR 685.2

Recombinant Human Neurotrophin-4 (NT-4)

HEOPP-1405 10ug Ask for price

Recombinant Human NTF3/ Neurotrophin 3 Protein, Untagged, E.coli-10ug

QP1246-10ug 10ug
EUR 284.4

Recombinant Human NTF3/ Neurotrophin 3 Protein, Untagged, E.coli-1mg

QP1246-1mg 1mg
EUR 5942.4

Recombinant Human NTF3/ Neurotrophin 3 Protein, Untagged, E.coli-2ug

QP1246-2ug 2ug
EUR 163.2

NT-4 Neurotrophin-4 Human Recombinant Protein

PROTP34130 Regular: 10ug
EUR 380.4
Description: Neurotrophin-4 Human Recombinant produced in E.Coli is a noncovalently linked homodimer, non-glycosylated polypeptide chain containing 2 x 130 amino acids (81-210 amino acids) and having a total molecular mass of 28 kDa. ;The NT-4 is purified by proprietary chromatographic techniques.

Recombinant Human NTF3/ Neurotrophin 3 Protein, Untagged, E.coli-100ug

QP1246-100ug 100ug
EUR 849.6

Recombinant Human NTF3/ Neurotrophin 3 Protein, Untagged, E.coli-500ug

QP1246-500ug 500ug
EUR 3645.6

Recombinant Neurotrophin 4 (NT4)

4-RPA107Hu01
  • EUR 614.59
  • EUR 288.00
  • EUR 1974.72
  • EUR 738.24
  • EUR 1356.48
  • EUR 487.20
  • EUR 4756.80
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Neurotrophin 4 expressed in: E.coli

Recombinant Neurotrophin 4 (NT4)

4-RPA107Mu01
  • EUR 601.69
  • EUR 284.40
  • EUR 1926.34
  • EUR 722.11
  • EUR 1324.22
  • EUR 477.60
  • EUR 4635.84
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Neurotrophin 4 expressed in: E.coli

Recombinant Neurotrophin 4 (NT4)

RPU43034-100ug 100ug
EUR 552.2

Recombinant Neurotrophin 4 (NT4)

RPU43034-1mg 1mg
EUR 2446.6

Recombinant Neurotrophin 4 (NT4)

RPU43034-50ug 50ug
EUR 443.3

Recombinant Neurotrophin 4 (NT4)

RPU53898-100ug 100ug
EUR 566.5

Recombinant Neurotrophin 4 (NT4)

RPU53898-1mg 1mg
EUR 2511.6

Recombinant Neurotrophin 4 (NT4)

RPU53898-50ug 50ug
EUR 455.4

Recombinant Neurotrophin 4 (NT4)

RPU59108-100ug 100ug
EUR 1044.4

Recombinant Neurotrophin 4 (NT4)

RPU59108-1mg 1mg
EUR 4083.3

Recombinant Neurotrophin 4 (NT4)

RPU59108-50ug 50ug
EUR 652.6

Recombinant Neurotrophin 4 (NT4)

RPU56286-100ug 100ug
EUR 775.5

Recombinant Neurotrophin 4 (NT4)

RPU56286-1mg 1mg
EUR 3057.6

Recombinant Neurotrophin 4 (NT4)

RPU56286-50ug 50ug
EUR 470.4

Recombinant Human Neurotrophin-3

7-01294 2µg Ask for price

Recombinant Human Neurotrophin-3

7-01295 10µg Ask for price

Recombinant Human Neurotrophin-3

7-01296 1mg Ask for price

Human Neurotrophin-3 (Recombinant)

22060430-1 2 µg
EUR 146.42

Recombinant Human Neurotrophin-3/NT3

C079-10ug 10ug
EUR 242.4
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 250mM NaCl, pH 7.2.

Recombinant Human Neurotrophin-3/NT3

C079-1mg 1mg
EUR 2739.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 250mM NaCl, pH 7.2.

Recombinant Human Neurotrophin-3/NT3

C079-500ug 500ug
EUR 1910.4
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 250mM NaCl, pH 7.2.

Recombinant Human Neurotrophin-3/NT3

C079-50ug 50ug
EUR 595.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 250mM NaCl, pH 7.2.

Recombinant Human Precursor Neurotrophin-3

7-01297 2µg Ask for price

Recombinant Human Precursor Neurotrophin-3

7-01298 10µg Ask for price

Recombinant Human Precursor Neurotrophin-3

7-01299 1mg Ask for price

Recombinant Mouse NTF3/ Neurotrophin 3 Protein, Untagged, E.coli-10ug

QP5425-10ug 10ug
EUR 284.4

Recombinant Mouse NTF3/ Neurotrophin 3 Protein, Untagged, E.coli-1mg

QP5425-1mg 1mg
EUR 5942.4

Recombinant Mouse NTF3/ Neurotrophin 3 Protein, Untagged, E.coli-2ug

QP5425-2ug 2ug
EUR 163.2

Recombinant Mouse NTF3/ Neurotrophin 3 Protein, Untagged, E.coli-100ug

QP5425-100ug 100ug
EUR 849.6

Recombinant Mouse NTF3/ Neurotrophin 3 Protein, Untagged, E.coli-500ug

QP5425-500ug 500ug
EUR 3645.6

Genorise® recombinant Sheep Neurotrophin 4

GR123022 5 µg
EUR 285

Recombinant Human NT-3/Neurotrophin-3 Protein

RP00496 10 μg
EUR 265.2

Recombinant Human NT-3/Neurotrophin-3 Protein

E40KMP1632 20ug
EUR 495

NNT1 Neurotrophin-1 Human Recombinant Protein

PROTQ9UBD9-1 Regular: 10ug
EUR 380.4
Description: Neurotrophin-1 Human Recombinant (28-225) produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 199 amino acids and having a molecular mass of 22kDa.;The NNT-1 is purified by proprietary chromatographic techniques.

Recombinant Mouse Neurotrophin-3

7-01300 2µg Ask for price

Recombinant Mouse Neurotrophin-3

7-01301 10µg Ask for price

Recombinant Mouse Neurotrophin-3

7-01302 1mg Ask for price

NT-3 Neurotrophin-3 Human Recombinant Protein

PROTP20783 Regular: 10ug
EUR 380.4
Description: Neurotrophin-3 Human Recombinant produced in E.Coli is a non-glycosylated and non-covalently linked homodimer, containing 2x119 amino acid chains, having a total Mw of 27.2 kDa.;The NT-3 is purified by proprietary chromatographic techniques.

Recombinant Neurotrophin 3 (NT3)

4-RPA106Hu01
  • EUR 582.34
  • EUR 279.60
  • EUR 1853.76
  • EUR 697.92
  • EUR 1275.84
  • EUR 465.60
  • EUR 4454.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Neurotrophin 3 expressed in: E.coli

Recombinant Neurotrophin 3 (NT3)

4-RPA106Hu02
  • EUR 582.34
  • EUR 279.60
  • EUR 1853.76
  • EUR 697.92
  • EUR 1275.84
  • EUR 465.60
  • EUR 4454.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Neurotrophin 3 expressed in: E.coli

Recombinant Neurotrophin 3 (NT3)

4-RPA106Ra01
  • EUR 614.59
  • EUR 288.00
  • EUR 1974.72
  • EUR 738.24
  • EUR 1356.48
  • EUR 487.20
  • EUR 4756.80
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Recombinant Neurotrophin 3 (NT3) expressed in: E.coli

Recombinant Neurotrophin 3 (NT3)

4-RPA106Ra02
  • EUR 485.57
  • EUR 253.20
  • EUR 1490.88
  • EUR 576.96
  • EUR 1033.92
  • EUR 400.80
  • EUR 3547.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Neurotrophin 3 expressed in: E.coli

Recombinant Neurotrophin 3 (NT3)

RPU43032-100ug 100ug
EUR 530.2

Recombinant Neurotrophin 3 (NT3)

RPU43032-1mg 1mg
EUR 2347.8

Recombinant Neurotrophin 3 (NT3)

RPU43032-50ug 50ug
EUR 425.7

Recombinant Neurotrophin 3 (NT3)

RPU43033-100ug 100ug
EUR 530.2

Recombinant Neurotrophin 3 (NT3)

RPU43033-1mg 1mg
EUR 2347.8

Recombinant Neurotrophin 3 (NT3)

RPU43033-50ug 50ug
EUR 425.7

Recombinant Neurotrophin 3 (NT3)

RPU55489-100ug 100ug
EUR 728.2

Recombinant Neurotrophin 3 (NT3)

RPU55489-1mg 1mg
EUR 2870.4

Recombinant Neurotrophin 3 (NT3)

RPU55489-50ug 50ug
EUR 441.6

Recombinant Neurotrophin 3 (NT3)

RPU56654-100ug 100ug
EUR 470.4

Recombinant Neurotrophin 3 (NT3)

RPU56654-1mg 1mg
EUR 2184

Recombinant Neurotrophin 3 (NT3)

RPU56654-50ug 50ug
EUR 385

Recombinant Neurotrophin 3 (NT3)

RPU56113-100ug 100ug
EUR 554.4

Recombinant Neurotrophin 3 (NT3)

RPU56113-1mg 1mg
EUR 2184

Recombinant Neurotrophin 3 (NT3)

RPU56113-50ug 50ug
EUR 336

Neurotrophin-3 Recombinant Protein

91-065 0.05 mg
EUR 821.4
Description: Neurotrophin-3 (NT-3) is a member of the NGF family of neurotrophic factors and is structurally related to beta -NGF, BDNF and NT-4. The NT3 cDNA encodes a 257 amino acid residue precursor protein with a signal peptide and a proprotein that are cleaved to yield the 119 amino acid residue mature NT3.The amino acid sequences of mature human, murine and rat NT-3 are identical. NT-3 selectively promotes the differentiation and survival of specific neuronal subpopulations in both the central as well as the peripheral nervous systems.

Recombinant Human Neurotrophin-3 Polypeptide (a. a. 119)

DAG339 10ug
EUR 897.6

Genorise® Recombinant Equine Neurotrophin-4 protein

GR104319 5 µg
EUR 285

Human Neurotrophin 3 (NTF3) Protein

20-abx262233
  • EUR 393.60
  • EUR 6991.20
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Genorise® recombinant Bovine Neurotrophin 4 protein

GR120051 5 µg
EUR 285

Genorise® recombinant Canine Neurotrophin 4 protein

GR122076 5 µg
EUR 285

Genorise® Recombinant feline Neurotrophin 4 (NT-4) protein

GR186036 5 mg
EUR 285

Human Neurotrophin 3 (NTF3) ELISA Kit

20-abx152511
  • EUR 7970.40
  • EUR 4250.40
  • EUR 990.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Neurotrophin 3 (NTF3) ELISA Kit

abx251814-96tests 96 tests
EUR 904.8

Human Neurotrophin 3 (NTF3) ELISA Kit

abx050174-96tests 96 tests
EUR 801.6

Human Neurotrophin 3 (NTF3) ELISA Kit

abx052323-96tests 96 tests
EUR 904.8

Human Neurotrophin 3 (NTF3) ELISA Kit

abx576324-96tests 96 tests
EUR 904.8

Human Neurotrophin-3 (NTF3) ELISA Kit

RK06211 96T
EUR 280

Human Neurotrophin-3 Recombinant Protein Tag Free Lyophilized

IHUNT3RTFLY50UG each
EUR 988
Description: Human Neurotrophin-3 Recombinant Protein Tag Free Lyophilized

Human NTF3/ Neurotrophin-3 ELISA Kit

E1802Hu 1 Kit
EUR 644.4

NT-3 Neurotrophin-3 Mouse Recombinant Protein

PROTP20181 Regular: 10ug
EUR 380.4
Description: Neurotrophin-3 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 119 amino acids and having a molecular mass of 13.6kDa. ;The NT-3 is purified by proprietary chromatographic techniques.

Genorise® recombinant Sheep Neurotrophin 3

GR123021 5 µg
EUR 285

Neurotrophin 3 (NTF3) Antibody

abx235882-100ug 100 ug
EUR 610.8

Neurotrophin 3 (NTF3) Antibody

20-abx213971
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Neurotrophin 3 (NTF3) Antibody

20-abx114092
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Neurotrophin 3 (NTF3) Antibody

20-abx320637
  • EUR 360.00
  • EUR 292.80
  • 100 ul
  • 50 ul

In conclusion, XQLT hampered Der p allergen-induced NGF, p75NTR and TSLP expression. This inhibition is attenuated by sTLR 4 . The working mechanism of XQLT may be correlated with TLR 4 , the main receptors in the innate immune system. The findings of this study can focus on the pharmacological target search XQLT to TLR 4 , which is important in the presentation of allergens path.