Background In the animal combined and Human study, we have previously found that treatment of 5-day increase the plasticity of cortical also facilitates brain – derived neurotrophic factor ( BDNF ) – receptor tyrosine kinase B (TrkB) signaling and increased activated TrkB and N-methyl-d-aspartate receptor (NMDAR) association in both the cortex and peripheral lymphocytes.

Patients with Parkinson’s disease (PD), in general, show decreased cortical plasticity, as shown by electrophysiological and behavioral studies. Here, we tested the hypothesis that exercise programs that improve motor function and appears to slow the progression of symptoms can improve BDNF -TrkB signals in lymphocytes. Methods A total of 16 patients with PD experience 4 -week intensive multidisciplinary rehabilitation treatment (MIRT), which includes aerobic exercise and physical and occupational therapy.

Blood was collected before and after 2 and 4 MIRT week. Lymphocytes isolated to check the BDNF -TrkB signaling caused by incubation with recombinant Human BDNF . TrkB signaling complex, extracellular-signal-regulated kinase-2 and protein-kinase-B immunoprecipitated; immunocomplexes contents determined by Western blotting. Results After MIRT, all patients showed improvements in motor function. TrkB interaction with NMDAR and BDNF -TrkB signaling increases in peripheral lymphocyte receptor, intracellular mediators, and the downstream level.

The decrements in the Unified Parkinson’s Disease Rating Scale II (UPDRSII) and total scores were significantly correlated with the increase in receptor TrkB signaling, intracellular mediators, and the level of interaction of NMDAR. Conclusion The significant correlation between reduced UPDRS score and change the activity of lymphocytes demonstrated that improved BDNF -TrkB signaling in lymphocytes and reduce the severity of symptoms of PD may be related.

Intensive Rehabilitation Enhances Lymphocyte BDNF-TrkB Signaling in Patients With Parkinson's Disease.
Intensive Rehabilitation Enhances Lymphocyte BDNF-TrkB Signaling in Patients With Parkinson’s Disease.

Late pulses like receptor 4 inversely attenuating the effects of Chinese herbal Xiao-Qing-Long-Tang on allergen-induced nerve growth factor and thymic stromal lymphopoietin.4

Xiao-Qing-Long-Tang (XQLT) is known to regulate the immune allergic reaction. The purpose of this study was to investigate the effects of XQLT on allergen-induced cytokine and related signaling pathways. A rat model of acute allergic used to investigate the effects of XQLT on nerve growth factor (NGF) during an allergic reaction, while Human pulmonary alveolar epithelial cells (HPAEpiCs) was used to investigate the effects of XQLT on Dermatophagoides pteronyssinus group 2 ( der p 2) -induced NGF, p75 neurotrophin receptor (p75NTR) and thymic stromal lymphopoietin (TSLP) expression. XQLT shown to inhibit allergic reactions associated NGF- and p75NTR in a mouse model.

XQLT also reduce the expression of Toll-like receptor 4 (TLR 4 ) in the lungs of rat models. XQLT inhibit Der p 2-induced NGF, TSLP and p75NTR expression in cell lines HPAEpiC. The use recombinant TLR soluble 4 (sTLR 4 ) in the competitive test XQLT partially attenuated inhibitory effect on NGF, TSLP and p75NTR expression in HPAEpiC cells. XQLT inhibitory effect on Ser536 phosphorylation of p65 (nuclear factor-kB; NF-kB), a TLR 4 the impact factor, is also attenuated by sTLR 4 .

Recombinant Human Neurotrophin-3 (NTF3)

CSB-BP016120HU 7886 mg Ask for price

Recombinant Human Neurotrophin-3 (NTF3)

CSB-EP016120HU 7990 mg Ask for price

Recombinant Human Neurotrophin-3 (NTF3)

CSB-MP016120HU 7843 mg Ask for price

Recombinant Human Neurotrophin-3 (NTF3)

RPC27838-100ug 100ug
EUR 1463

Recombinant Human Neurotrophin-3 (NTF3)

RPC27838-1mg 1mg
EUR 6879.6

Recombinant Human Neurotrophin-3 (NTF3)

RPC27838-20ug 20ug
EUR 550

Recombinant Human Neurotrophin-3 (NTF3)

RPC28701-100ug 100ug
EUR 1170.4

Recombinant Human Neurotrophin-3 (NTF3)

RPC28701-1mg 1mg
EUR 3252

Recombinant Human Neurotrophin-3 (NTF3)

RPC28701-20ug 20ug
EUR 440

Recombinant Human Neurotrophin-3 (NTF3)

RPC28729-100ug 100ug
EUR 528

Recombinant Human Neurotrophin-3 (NTF3)

RPC28729-1mg 1mg
EUR 2412.5

Recombinant Human Neurotrophin-3 (NTF3)

RPC28729-20ug 20ug
EUR 295.7

NTF4 (GFP-tagged) - Human neurotrophin 4 (NTF4)

RG204535 10 µg Ask for price

Recombinant Human Neurotrophin-3 (NTF3) (Active)

CSB-AP003801HU 8580 mg Ask for price

Human Neurotrophin 4 (NTF4) Protein

20-abx262207
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  • 10 ug
  • 1 mg
  • 2 µg

Human Neurotrophin 4 (NTF4) Protein

abx262207-10mg 10 mg
EUR 325

Human Neurotrophin 4 (NTF4) Protein

abx262207-25mg 25 mg
EUR 5975

Human Neurotrophin 4 (NTF4) Protein

abx262207-5mg 5 mg
EUR 225

NTF4 (Myc-DDK-tagged)-Human neurotrophin 4 (NTF4)

RC204535 10 µg Ask for price

Human Neurotrophin 4 (NTF4) CLIA Kit

abx197346-100l 100 µl Ask for price

Human Neurotrophin 4 (NTF4) CLIA Kit

abx197346-50l 50 µl
EUR 618.75

Recombinant Human Neurotrophin 3/NTF3 protein (His tag)

PDEH100226-100ug 100ug
EUR 118
Description: Human

Recombinant Human Neurotrophin 3/NTF3 protein (His tag)

PDEH100226-20ug 20ug
EUR 68
Description: Human

Recombinant Human Neurotrophin-3/NTF3 Protein (Active)

PKSH032803-10ug 10ug
EUR 178
Description: Human

Recombinant Human Neurotrophin-3/NTF3 Protein (Active)

PKSH032803-50ug 50ug
EUR 523
Description: Human

Human Neurotrophin 4 (NTF4) ELISA Kit

20-abx152512
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Neurotrophin 4 (NTF4) ELISA Kit

abx050177-96tests 96 tests
EUR 782.4

Human Neurotrophin 4 (NTF4) ELISA Kit

abx251825-96tests 96 tests
EUR 848.4

Human Neurotrophin 4 (NTF4) ELISA Kit

abx575476-96tests 96 tests
EUR 848.4

Recombinant Rat Neurotrophin-3 (Ntf3)

CSB-EP016120RA 10360 mg Ask for price

Neurotrophin 4 (NTF4) Antibody

20-abx110042
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Neurotrophin 4 (NTF4) Antibody

abx145494-100ug 100 ug
EUR 469.2

Neurotrophin 4 (NTF4) Antibody

20-abx142109
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  • 100 ul
  • 200 ul
  • 50 ul

Neurotrophin 4 (NTF4) Antibody

20-abx114093
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  • 150 ul
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Neurotrophin 4 (NTF4) Antibody

20-abx002282
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  • 100 ul
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Neurotrophin 4 (NTF4) Antibody

20-abx001004
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  • 100 ul
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Neurotrophin 4 (NTF4) Antibody

abx235682-100ug 100 ug
EUR 577.2

Neurotrophin 4 (NTF4) Antibody

20-abx326456
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  • 100 ug
  • 50 ug

Neurotrophin 4 (NTF4) Antibody

20-abx241784
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  • 100 ul
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Neurotrophin 4 (NTF4) Antibody

abx002282-100l 100 µl
EUR 400

Neurotrophin 4 (NTF4) Antibody

abx002282-20l 20 µl
EUR 175

Neurotrophin 4 (NTF4) Antibody

abx002282-50l 50 µl
EUR 275

Neurotrophin 4 (NTF4) Antibody

abx001004-100l 100 µl
EUR 400

Neurotrophin 4 (NTF4) Antibody

abx001004-20l 20 µl
EUR 175

Neurotrophin 4 (NTF4) Antibody

abx001004-50l 50 µl
EUR 275

Neurotrophin 4 (NTF4) Antibody

abx110042-100l 100 µl
EUR 162.5

Neurotrophin 4 (NTF4) Antibody

abx114093-100l 100 µl
EUR 612.5

Neurotrophin 4 (NTF4) Antibody

abx235682-100g 100 µg
EUR 350

Neurotrophin 4 (NTF4) Antibody

abx241784-96tests 96 tests
EUR 250

Neurotrophin 4 (NTF4) Antibody

abx145494-1096tests 10 × 96 tests Ask for price

Neurotrophin 4 (NTF4) Antibody

abx145494-596tests 5 × 96 tests Ask for price

Neurotrophin 4 (NTF4) Antibody

abx145494-96tests 96 tests
EUR 337.5

Neurotrophin 4 (NTF4) Antibody

abx326456-100g 100 µg
EUR 250

Neurotrophin 4 (NTF4) Antibody

abx326456-50g 50 µg
EUR 187.5

Human NTF4/ Neurotrophin-4 ELISA Kit

E2816Hu 1 Kit
EUR 515
Description: NTF5,Neurotrophin-5,Neutrophic factor 4,NT-5

Human NTF4 / Neurotrophin-4 ELISA Kit

E0107h 96T
EUR 736

Neurotrophin-4 (NTF4) Antibody

20-abx137025
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  • 0.5 mg
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Neurotrophin-4 (NTF4) Antibody

abx137025-01mg 0.1 mg
EUR 487.5

Recombinant Human NT-3/Neurotrophin-3/NTF3 Protein, No Tag

E40KMH1479 20ug
EUR 495

Recombinant Human Neurotrophin-4

AP60103 100ug
EUR 1554

Recombinant Human Neurotrophin-4

7-01303 2µg Ask for price

Recombinant Human Neurotrophin-4

7-01304 10µg Ask for price

Recombinant Human Neurotrophin-4

7-01305 1mg Ask for price

Recombinant Human Neurotrophin-4

cyt-626-10g 10µg
EUR 145

Recombinant Human Neurotrophin-4

cyt-626-1mg 1mg
EUR 4680

Recombinant Human Neurotrophin-4

cyt-626-2g 2µg
EUR 60

Neurotrophin 4 Antibody / NTF4

RQ5832 100 ug
EUR 356.15
Description: Neurotrophin-4 (NT-4), also known as neurotrophin-5 (NT-5), is a protein that in humans is encoded by the NTF4 gene. This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood.

Neurotrophin-4, recombinant (Human)

033-30 10 μg
EUR 390.96

Neurotrophin-4 Human Recombinant

rAP-2701 Inquiry Ask for price

Ntf4 (untagged ORF) - Rat neurotrophin 4 (Ntf4), (10 ug)

RN211853 10 µg Ask for price

Recombinant Human Neurotrophin-4 (NT-4)

HEOPP-1405 10ug Ask for price

Rat Neurotrophin 4 (NTF4) CLIA Kit

abx197348-100l 100 µl Ask for price

Rat Neurotrophin 4 (NTF4) CLIA Kit

abx197348-50l 50 µl
EUR 618.75

Rat Neurotrophin 4 (NTF4) ELISA Kit

abx050178-96tests 96 tests
EUR 782.4

Rat Neurotrophin 4 (NTF4) ELISA Kit

abx255863-96tests 96 tests
EUR 848.4

Rat Neurotrophin 4 (NTF4) ELISA Kit

abx575477-96tests 96 tests
EUR 848.4

Rat Neurotrophin 4 (NTF4) ELISA Kit

20-abx155889
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  • 10 × 96 tests
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  • 96 tests

Pig Neurotrophin 4 (NTF4) ELISA Kit

abx362091-96tests 96 tests
EUR 990

Rat Neurotrophin 4 (NTF4) ELISA Kit

abx050178-100g 100 µg Ask for price

Rat Neurotrophin 4 (NTF4) ELISA Kit

abx050178-10g 10 µg
EUR 531.25

Rat Neurotrophin 4 (NTF4) ELISA Kit

abx050178-50g 50 µg Ask for price

Rat Neurotrophin 4 (NTF4) ELISA Kit

abx155889-100g 100 µg
EUR 6075

Rat Neurotrophin 4 (NTF4) ELISA Kit

abx155889-10g 10 µg
EUR 675

Rat Neurotrophin 4 (NTF4) ELISA Kit

abx155889-50g 50 µg
EUR 3212.5

Pig Neurotrophin 4 (NTF4) ELISA Kit

abx362091-100g 100 µg
EUR 743.75

Mouse Neurotrophin 4 (NTF4) CLIA Kit

abx197347-100l 100 µl Ask for price

Mouse Neurotrophin 4 (NTF4) CLIA Kit

abx197347-50l 50 µl
EUR 618.75

Mouse Neurotrophin 4 (NTF4) ELISA Kit

abx050179-96tests 96 tests
EUR 782.4

Mouse Neurotrophin 4 (NTF4) ELISA Kit

abx254300-96tests 96 tests
EUR 848.4

Mouse Neurotrophin 4 (NTF4) ELISA Kit

abx574572-96tests 96 tests
EUR 848.4

Mouse Neurotrophin 4 (NTF4) ELISA Kit

20-abx154459
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Sheep Neurotrophin 4 (NTF4) ELISA Kit

abx364700-96tests 96 tests
EUR 1111.2

Mouse Neurotrophin 4 (NTF4) ELISA Kit

abx050179-100g 100 µg Ask for price

Mouse Neurotrophin 4 (NTF4) ELISA Kit

abx050179-10g 10 µg
EUR 525

Mouse Neurotrophin 4 (NTF4) ELISA Kit

abx050179-50g 50 µg Ask for price

Rabbit Neurotrophin 4 (NTF4) ELISA Kit

abx362259-96tests 96 tests
EUR 990

Monkey Neurotrophin 4 (NTF4) ELISA Kit

abx360359-96tests 96 tests
EUR 990

Monkey Neurotrophin 4 (NTF4) ELISA Kit

abx360359-1096tests 10 × 96 tests Ask for price

Monkey Neurotrophin 4 (NTF4) ELISA Kit

abx360359-596tests 5 × 96 tests
EUR 662.5

Recombinant Human NTF3/ Neurotrophin 3 Protein, Untagged, E.coli-10ug

QP1246-10ug 10ug
EUR 284.4

Recombinant Human NTF3/ Neurotrophin 3 Protein, Untagged, E.coli-1mg

QP1246-1mg 1mg
EUR 5942.4

Recombinant Human NTF3/ Neurotrophin 3 Protein, Untagged, E.coli-2ug

QP1246-2ug 2ug
EUR 163.2

Chicken Neurotrophin 4 (NTF4) ELISA Kit

abx356910-96tests 96 tests
EUR 990

Rat Ntf4/ Neurotrophin-4 ELISA Kit

E0702Ra 1 Kit
EUR 557
Description: Nt4,Ntf5,Neurotrophin-5,Neutrophic factor 4,NT-5

Rat Ntf4 / Neurotrophin-4 ELISA Kit

E0107r 96T
EUR 796

Recombinant Human NTF3/ Neurotrophin 3 Protein, Untagged, E.coli-100ug

QP1246-100ug 100ug
EUR 849.6

Recombinant Human NTF3/ Neurotrophin 3 Protein, Untagged, E.coli-500ug

QP1246-500ug 500ug
EUR 3645.6

Mouse Ntf4 / Neurotrophin-4 ELISA Kit

E0107m 96T
EUR 776

Neurotrophin 4 (NTF4) goat polyclonal antibody

GT15001-100 100 µg Ask for price

Recombinant Human Neurotrophin-3

7-01294 2µg Ask for price

Recombinant Human Neurotrophin-3

7-01295 10µg Ask for price

Recombinant Human Neurotrophin-3

7-01296 1mg Ask for price

Recombinant Human Neurotrophin-1

cyt-869-10g 10µg
EUR 145

Recombinant Human Neurotrophin-1

cyt-869-1mg 1mg
EUR 4680

Recombinant Human Neurotrophin-1

cyt-869-2g 2µg
EUR 60

Recombinant Human Neurotrophin-3

cyt-257-10g 10µg
EUR 145

Recombinant Human Neurotrophin-3

cyt-257-1mg 1mg
EUR 4680

Recombinant Human Neurotrophin-3

cyt-257-2g 2µg
EUR 60

Ntf4 (Myc-DDK-tagged ORF) - Rat neurotrophin 4 (Ntf4), (10 ug)

RR211853 10 µg Ask for price

Neurotrophin-3, recombinant (Human)

033-29 10 μg
EUR 390.96

NT-4 Neurotrophin-4 Human Recombinant Protein

PROTP34130 Regular: 10ug
EUR 380.4
Description: Neurotrophin-4 Human Recombinant produced in E.Coli is a noncovalently linked homodimer, non-glycosylated polypeptide chain containing 2 x 130 amino acids (81-210 amino acids) and having a total molecular mass of 28 kDa. ;The NT-4 is purified by proprietary chromatographic techniques.

Human Neurotrophin-3 (Recombinant)

22060430-1 2 µg
EUR 146.42

Lenti ORF clone of Human neurotrophin 4 (NTF4), mGFP tagged

RC204535L4 10 µg Ask for price

Neurotrophin-3 Human Recombinant

rAP-2697 Inquiry Ask for price

In conclusion, XQLT hampered Der p allergen-induced NGF, p75NTR and TSLP expression. This inhibition is attenuated by sTLR 4 . The working mechanism of XQLT may be correlated with TLR 4 , the main receptors in the innate immune system. The findings of this study can focus on the pharmacological target search XQLT to TLR 4 , which is important in the presentation of allergens path.