Background In the animal combined and Human study, we have previously found that treatment of 5-day increase the plasticity of cortical also facilitates brain – derived neurotrophic factor ( BDNF ) – receptor tyrosine kinase B (TrkB) signaling and increased activated TrkB and N-methyl-d-aspartate receptor (NMDAR) association in both the cortex and peripheral lymphocytes.
Patients with Parkinson’s disease (PD), in general, show decreased cortical plasticity, as shown by electrophysiological and behavioral studies. Here, we tested the hypothesis that exercise programs that improve motor function and appears to slow the progression of symptoms can improve BDNF -TrkB signals in lymphocytes. Methods A total of 16 patients with PD experience 4 -week intensive multidisciplinary rehabilitation treatment (MIRT), which includes aerobic exercise and physical and occupational therapy.
Blood was collected before and after 2 and 4 MIRT week. Lymphocytes isolated to check the BDNF -TrkB signaling caused by incubation with recombinant Human BDNF . TrkB signaling complex, extracellular-signal-regulated kinase-2 and protein-kinase-B immunoprecipitated; immunocomplexes contents determined by Western blotting. Results After MIRT, all patients showed improvements in motor function. TrkB interaction with NMDAR and BDNF -TrkB signaling increases in peripheral lymphocyte receptor, intracellular mediators, and the downstream level.
The decrements in the Unified Parkinson’s Disease Rating Scale II (UPDRSII) and total scores were significantly correlated with the increase in receptor TrkB signaling, intracellular mediators, and the level of interaction of NMDAR. Conclusion T he significant correlation between reduced UPDRS score and change the activity of lymphocytes demonstrated that improved BDNF -TrkB signaling in lymphocytes and reduce the severity of symptoms of PD may be related.
Intensive Rehabilitation Enhances Lymphocyte BDNF-TrkB Signaling in Patients With Parkinson’s Disease.
Late pulses like receptor 4 inversely attenuating the effects of Chinese herbal Xiao-Qing-Long-Tang on allergen-induced nerve growth factor and thymic stromal lymphopoietin.4
Xiao-Qing-Long-Tang (XQLT) is known to regulate the immune allergic reaction. The purpose of this study was to investigate the effects of XQLT on allergen-induced cytokine and related signaling pathways. A rat model of acute allergic used to investigate the effects of XQLT on nerve growth factor (NGF) during an allergic reaction, while Human pulmonary alveolar epithelial cells (HPAEpiCs) was used to investigate the effects of XQLT on Dermatophagoides pteronyssinus group 2 ( der p 2) -induced NGF, p75 neurotrophin receptor (p75NTR) and thymic stromal lymphopoietin (TSLP) expression. XQLT shown to inhibit allergic reactions associated NGF- and p75NTR in a mouse model.
XQLT also reduce the expression of Toll-like receptor 4 (TLR 4 ) in the lungs of rat models. XQLT inhibit Der p 2-induced NGF, TSLP and p75NTR expression in cell lines HPAEpiC. The use recombinant TLR soluble 4 (sTLR 4 ) in the competitive test XQLT partially attenuated inhibitory effect on NGF, TSLP and p75NTR expression in HPAEpiC cells. XQLT inhibitory effect on Ser536 phosphorylation of p65 (nuclear factor-kB; NF-kB), a TLR 4 the impact factor, is also attenuated by sTLR 4 .
Recombinant Human Neurotrophin-4 (NTF4), partial
CSB-EP016121HU1
Cusabio
1830 mg
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Recombinant Human Neurotrophin-4 (NTF4), partial
CSB-EP016121HU1-100ug
Cusabio
100ug
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Recombinant Human Neurotrophin-4 (NTF4), partial
CSB-EP016121HU1-1mg
Cusabio
1mg
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Description: 82-210aa
Recombinant Human Neurotrophin-4 (NTF4), partial
CSB-EP016121HU1-20ug
Cusabio
20ug
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Description: 82-210aa
Recombinant Human Neurotrophin-4 protein (NTF4)
MBS9423137-001mg
MyBiosource
0.01mg
EUR 365
Recombinant Human Neurotrophin-4 protein (NTF4)
MBS9423137-01mg
MyBiosource
0.1mg
EUR 1925
Recombinant Human Neurotrophin-4 protein (NTF4)
MBS9423137-025mg
MyBiosource
0.25mg
EUR 3385
Recombinant Human Neurotrophin-4 protein (NTF4)
MBS9423137-05mg
MyBiosource
0.5mg
EUR 4375
Recombinant Human Neurotrophin-4 protein (NTF4)
MBS9423137-1mg
MyBiosource
1mg
EUR 5920
Recombinant Rat Neurotrophin-4 (Ntf4)
MBS953076-002mgBaculovirus
MyBiosource
0.02mg(Baculovirus)
EUR 1050
Recombinant Rat Neurotrophin-4 (Ntf4)
MBS953076-002mgEColi
MyBiosource
0.02mg(E-Coli)
EUR 635
Recombinant Rat Neurotrophin-4 (Ntf4)
MBS953076-002mgYeast
MyBiosource
0.02mg(Yeast)
EUR 805
Recombinant Rat Neurotrophin-4 (Ntf4)
MBS953076-01mgEColi
MyBiosource
0.1mg(E-Coli)
EUR 735
Recombinant Rat Neurotrophin-4 (Ntf4)
MBS953076-01mgYeast
MyBiosource
0.1mg(Yeast)
EUR 940
Recombinant Human Neurotrophin-4 protein(NTF4) (Active)
AP73547
SAB
1mg
EUR 6829
Recombinant Human Neurotrophin-4 protein (NTF4) (Active)
CSB-AP002831HU
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8451 mg
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Recombinant Human Neurotrophin-4 protein (NTF4) (Active)
CSB-AP002831HU-100ug
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100ug
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Recombinant Human Neurotrophin-4 protein (NTF4) (Active)
CSB-AP002831HU-10ug
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10ug
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Recombinant Human Neurotrophin-4 protein (NTF4) (Active)
CSB-AP002831HU-500ug
Cusabio
500ug
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Recombinant Human Neurotrophin-4 protein (NTF4) (Active)
MBS969401-001mg
MyBiosource
0.01mg
EUR 355
Recombinant Human Neurotrophin-4 protein (NTF4) (Active)
MBS969401-01mg
MyBiosource
0.1mg
EUR 1590
Recombinant Human Neurotrophin-4 protein (NTF4) (Active)
MBS969401-05mg
MyBiosource
0.5mg
EUR 3395
Recombinant Human Neurotrophin-4 protein (NTF4) (Active)
MBS969401-5x05mg
MyBiosource
5x0.5mg
EUR 15240
Recombinant Mouse Neurotrophin-4 (Ntf4)
MBS1428509-002mgBaculovirus
MyBiosource
0.02mg(Baculovirus)
EUR 1050
Recombinant Mouse Neurotrophin-4 (Ntf4)
MBS1428509-002mgEColi
MyBiosource
0.02mg(E-Coli)
EUR 635
Recombinant Mouse Neurotrophin-4 (Ntf4)
MBS1428509-002mgYeast
MyBiosource
0.02mg(Yeast)
EUR 805
Recombinant Mouse Neurotrophin-4 (Ntf4)
MBS1428509-01mgEColi
MyBiosource
0.1mg(E-Coli)
EUR 735
Recombinant Mouse Neurotrophin-4 (Ntf4)
MBS1428509-01mgYeast
MyBiosource
0.1mg(Yeast)
EUR 940
Human Neurotrophin-4 (NTF4)
1-CSB-RP099294h
Cusabio
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Description: Recombinant Human Neurotrophin-4(NTF4) expressed in E.coli
Recombinant Xenopus laevis Neurotrophin-4 (ntf4)
MBS1021826-002mgBaculovirus
MyBiosource
0.02mg(Baculovirus)
EUR 1045
Recombinant Xenopus laevis Neurotrophin-4 (ntf4)
MBS1021826-002mgEColi
MyBiosource
0.02mg(E-Coli)
EUR 625
Recombinant Xenopus laevis Neurotrophin-4 (ntf4)
MBS1021826-002mgYeast
MyBiosource
0.02mg(Yeast)
EUR 800
Recombinant Xenopus laevis Neurotrophin-4 (ntf4)
MBS1021826-01mgEColi
MyBiosource
0.1mg(E-Coli)
EUR 725
Recombinant Xenopus laevis Neurotrophin-4 (ntf4)
MBS1021826-01mgYeast
MyBiosource
0.1mg(Yeast)
EUR 935
Recombinant Macrovipera lebetina Neurotrophin-4 (NTF4)
MBS1256872-002mgBaculovirus
MyBiosource
0.02mg(Baculovirus)
EUR 970
Recombinant Macrovipera lebetina Neurotrophin-4 (NTF4)
MBS1256872-002mgEColi
MyBiosource
0.02mg(E-Coli)
EUR 525
Recombinant Macrovipera lebetina Neurotrophin-4 (NTF4)
MBS1256872-002mgYeast
MyBiosource
0.02mg(Yeast)
EUR 720
Recombinant Macrovipera lebetina Neurotrophin-4 (NTF4)
MBS1256872-01mgEColi
MyBiosource
0.1mg(E-Coli)
EUR 625
Recombinant Macrovipera lebetina Neurotrophin-4 (NTF4)
MBS1256872-01mgYeast
MyBiosource
0.1mg(Yeast)
EUR 845
Human Neurotrophin 4 (NTF4) Protein
abx262207-10mg
Abbexa
10 mg
EUR 325
Human Neurotrophin 4 (NTF4) Protein
20-abx262207
Abbexa
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Human Neurotrophin 4 (NTF4) Protein
abx262207-25mg
Abbexa
25 mg
EUR 5975
Human Neurotrophin 4 (NTF4) Protein
abx262207-5mg
Abbexa
5 mg
EUR 225
Human Neurotrophin 4 (NTF4) CLIA Kit
20-abx491029
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Human Neurotrophin 4 (NTF4) CLIA Kit
abx197346-100l
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100 µl
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Human Neurotrophin 4 (NTF4) CLIA Kit
abx197346-50l
Abbexa
50 µl
EUR 618.75
Human Neurotrophin 4 (NTF4) ELISA Kit
abx050177-96tests
Abbexa
96 tests
EUR 782.4
Human Neurotrophin 4 (NTF4) ELISA Kit
20-abx152512
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5 × 96 tests
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Human Neurotrophin 4 (NTF4) ELISA Kit
abx251825-96tests
Abbexa
96 tests
EUR 525
Human Neurotrophin 4 (NTF4) ELISA Kit
abx575476-96tests
Abbexa
96 tests
EUR 848.4
Human NTF4/ Neurotrophin-4 ELISA Kit
E2816Hu
Sunlong
1 Kit
EUR 515
Description: NTF5,Neurotrophin-5,Neutrophic factor 4,NT-5
Human NTF4/Neurotrophin-4 ELISA Kit
E45K00542
EnoGene
96T
EUR 1008.85
Neurotrophin 4 (NTF4) Antibody
abx326456-100g
Abbexa
100 µg
EUR 250
Neurotrophin 4 (NTF4) Antibody
20-abx326456
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Neurotrophin 4 (NTF4) Antibody
abx326456-50g
Abbexa
50 µg
EUR 187.5
Neurotrophin 4 (NTF4) Antibody
abx001004-100l
Abbexa
100 µl
EUR 400
Neurotrophin 4 (NTF4) Antibody
20-abx001004
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Neurotrophin 4 (NTF4) Antibody
abx001004-20l
Abbexa
20 µl
EUR 175
Neurotrophin 4 (NTF4) Antibody
abx001004-50l
Abbexa
50 µl
EUR 275
Neurotrophin 4 (NTF4) Antibody
abx002282-100l
Abbexa
100 µl
EUR 400
Neurotrophin 4 (NTF4) Antibody
20-abx002282
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Neurotrophin 4 (NTF4) Antibody
abx002282-20l
Abbexa
20 µl
EUR 175
Neurotrophin 4 (NTF4) Antibody
abx002282-50l
Abbexa
50 µl
EUR 275
Neurotrophin 4 (NTF4) Antibody
20-abx142109
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Neurotrophin 4 (NTF4) Antibody
abx145494-100ug
Abbexa
100 ug
EUR 469.2
Neurotrophin 4 (NTF4) Antibody
abx145494-1096tests
Abbexa
10 × 96 tests
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Neurotrophin 4 (NTF4) Antibody
abx145494-596tests
Abbexa
5 × 96 tests
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Neurotrophin 4 (NTF4) Antibody
abx145494-96tests
Abbexa
96 tests
EUR 337.5
Neurotrophin 4 (NTF4) Antibody
abx114093-100l
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100 µl
EUR 612.5
Neurotrophin 4 (NTF4) Antibody
20-abx114093
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20-abx241784
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Neurotrophin 4 (NTF4) Antibody
abx241784-96tests
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96 tests
EUR 250
Neurotrophin 4 (NTF4) Antibody
20-abx110042
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1 mg
Neurotrophin 4 (NTF4) Antibody
abx110042-100l
Abbexa
100 µl
EUR 162.5
Neurotrophin 4 (NTF4) Antibody
abx235682-100g
Abbexa
100 µg
EUR 350
Neurotrophin 4 (NTF4) Antibody
abx235682-100ug
Abbexa
100 ug
EUR 577.2
Neurotrophin-4 (NTF4) Antibody
abx137025-01mg
Abbexa
0.1 mg
EUR 487.5
Neurotrophin-4 (NTF4) Antibody
20-abx137025
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Neurotrophin 4 (NTF4) (NM_006179) Human Over-expression Lysate
E45H08070-2
EnoGene
each
EUR 395
Neurotrophin 4 (NTF4) (NM_006179) Human Over-expression Lysate
LS004909
BosterBio
100ug
EUR 628
Description: Transient overexpression lysate of neurotrophin 4 (NTF4)
Recombinant Human Neurotrophin-3 (NTF3)
MBS7114977-001mg
MyBiosource
0.01mg
EUR 310
Recombinant Human Neurotrophin-3 (NTF3)
MBS7114977-005mg
MyBiosource
0.05mg
EUR 720
Recombinant Human Neurotrophin-3 (NTF3)
MBS7114977-5x005mg
MyBiosource
5x0.05mg
EUR 3045
Recombinant Human Neurotrophin-3 (NTF3)
CSB-EP016120HU
Cusabio
7990 mg
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Recombinant Human Neurotrophin-3 (NTF3)
CSB-EP016120HU-100ug
Cusabio
100ug
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Description: 139-257aa
Recombinant Human Neurotrophin-3 (NTF3)
CSB-EP016120HU-1mg
Cusabio
1mg
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Recombinant Human Neurotrophin-3 (NTF3)
CSB-EP016120HU-20ug
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20ug
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Recombinant Human Neurotrophin-3 (NTF3)
CSB-BP016120HU
Cusabio
7886 mg
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Recombinant Human Neurotrophin-3 (NTF3)
CSB-BP016120HU-100ug
Cusabio
100ug
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Recombinant Human Neurotrophin-3 (NTF3)
CSB-BP016120HU-1mg
Cusabio
1mg
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Description: 139-257aa
Recombinant Human Neurotrophin-3 (NTF3)
CSB-BP016120HU-20ug
Cusabio
20ug
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Description: 139-257aa
Recombinant Human Neurotrophin-3 (NTF3)
CSB-MP016120HU
Cusabio
7843 mg
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Recombinant Human Neurotrophin-3 (NTF3)
CSB-MP016120HU-100ug
Cusabio
100ug
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Description: 139-257aa
Recombinant Human Neurotrophin-3 (NTF3)
CSB-MP016120HU-1mg
Cusabio
1mg
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Description: 139-257aa
Recombinant Human Neurotrophin-3 (NTF3)
CSB-MP016120HU-20ug
Cusabio
20ug
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Description: 139-257aa
Recombinant Human Neurotrophin-3 (NTF3)
MBS954371-002mgBaculovirus
MyBiosource
0.02mg(Baculovirus)
EUR 390
Recombinant Human Neurotrophin-3 (NTF3)
MBS954371-002mgEColi
MyBiosource
0.02mg(E-Coli)
EUR 280
Recombinant Human Neurotrophin-3 (NTF3)
MBS954371-002mgMammalianCell
MyBiosource
0.02mg(Mammalian-Cell)
EUR 475
Recombinant Human Neurotrophin-3 (NTF3)
MBS954371-002mgYeast
MyBiosource
0.02mg(Yeast)
EUR 790
Recombinant Human Neurotrophin-3 (NTF3)
MBS954371-01mgEColi
MyBiosource
0.1mg(E-Coli)
EUR 460
NT-4 (Neurotrophin 4, Neurotrophin-4, NT4, Neutrophic Factor 4, NTF4, Neurotrophin 4/5, NT-4/5, NTF4/5, Neurotrophin 5, Neurotrophin-5, NT5, NT-5, Neutrophic Factor 5, NTF5)
MBS618954-01mL
MyBiosource
0.1mL
EUR 650
NT-4 (Neurotrophin 4, Neurotrophin-4, NT4, Neutrophic Factor 4, NTF4, Neurotrophin 4/5, NT-4/5, NTF4/5, Neurotrophin 5, Neurotrophin-5, NT5, NT-5, Neutrophic Factor 5, NTF5)
MBS618954-5x01mL
MyBiosource
5x0.1mL
EUR 2780
NT-4 (Neurotrophin 4, Neurotrophin-4, NT4, Neutrophic Factor 4, NTF4, Neurotrophin 4/5, NT-4/5, NTF4/5, Neurotrophin 5, Neurotrophin-5, NT5, NT-5, Neutrophic Factor 5, NTF5)
MBS615657-05mg
MyBiosource
0.5mg
EUR 650
NT-4 (Neurotrophin 4, Neurotrophin-4, NT4, Neutrophic Factor 4, NTF4, Neurotrophin 4/5, NT-4/5, NTF4/5, Neurotrophin 5, Neurotrophin-5, NT5, NT-5, Neutrophic Factor 5, NTF5)
MBS615657-5x05mg
MyBiosource
5x0.5mg
EUR 2780
NT-4 (Neurotrophin 4, Neurotrophin-4, NT4, Neutrophic Factor 4, NTF4, Neurotrophin 4/5, NT-4/5, NTF4/5, Neurotrophin 5, Neurotrophin-5, NT5, NT-5, Neutrophic Factor 5, NTF5)
MBS610753-05mg
MyBiosource
0.5mg
EUR 650
NT-4 (Neurotrophin 4, Neurotrophin-4, NT4, Neutrophic Factor 4, NTF4, Neurotrophin 4/5, NT-4/5, NTF4/5, Neurotrophin 5, Neurotrophin-5, NT5, NT-5, Neutrophic Factor 5, NTF5)
MBS610753-5x05mg
MyBiosource
5x0.5mg
EUR 2780
NT-4 (Neurotrophin 4, Neurotrophin-4, NT4, Neutrophic Factor 4, NTF4, Neurotrophin 4/5, NT-4/5, NTF4/5, Neurotrophin 5, Neurotrophin-5, NT5, NT-5, Neutrophic Factor 5, NTF5)
MBS617214-01mL
MyBiosource
0.1mL
EUR 650
NT-4 (Neurotrophin 4, Neurotrophin-4, NT4, Neutrophic Factor 4, NTF4, Neurotrophin 4/5, NT-4/5, NTF4/5, Neurotrophin 5, Neurotrophin-5, NT5, NT-5, Neutrophic Factor 5, NTF5)
MBS617214-5x01mL
MyBiosource
5x0.1mL
EUR 2780
NTF4 (Neurotrophin 4, Neurotrophin-4, NT-4/5, NT4, NT5, NTF5) (AP)
MBS6429785-01mL
MyBiosource
0.1mL
EUR 950
NTF4 (Neurotrophin 4, Neurotrophin-4, NT-4/5, NT4, NT5, NTF5) (AP)
MBS6429785-5x01mL
MyBiosource
5x0.1mL
EUR 4120
NTF4 (Neurotrophin 4, Neurotrophin-4, NT-4/5, NT4, NT5, NTF5) (PE)
MBS6429795-01mL
MyBiosource
0.1mL
EUR 950
NTF4 (Neurotrophin 4, Neurotrophin-4, NT-4/5, NT4, NT5, NTF5) (PE)
MBS6429795-5x01mL
MyBiosource
5x0.1mL
EUR 4120
In conclusion, XQLT hampered Der p allergen-induced NGF, p75NTR and TSLP expression. This inhibition is attenuated by sTLR 4 . The working mechanism of XQLT may be correlated with TLR 4 , the main receptors in the innate immune system. The findings of this study can focus on the pharmacological target search XQLT to TLR 4 , which is important in the presentation of allergens path.