Background In the animal combined and Human study, we have previously found that treatment of 5-day increase the plasticity of cortical also facilitates brain – derived neurotrophic factor ( BDNF ) – receptor tyrosine kinase B (TrkB) signaling and increased activated TrkB and N-methyl-d-aspartate receptor (NMDAR) association in both the cortex and peripheral lymphocytes.

Patients with Parkinson’s disease (PD), in general, show decreased cortical plasticity, as shown by electrophysiological and behavioral studies. Here, we tested the hypothesis that exercise programs that improve motor function and appears to slow the progression of symptoms can improve BDNF -TrkB signals in lymphocytes. Methods A total of 16 patients with PD experience 4 -week intensive multidisciplinary rehabilitation treatment (MIRT), which includes aerobic exercise and physical and occupational therapy.

Blood was collected before and after 2 and 4 MIRT week. Lymphocytes isolated to check the BDNF -TrkB signaling caused by incubation with recombinant Human BDNF . TrkB signaling complex, extracellular-signal-regulated kinase-2 and protein-kinase-B immunoprecipitated; immunocomplexes contents determined by Western blotting. Results After MIRT, all patients showed improvements in motor function. TrkB interaction with NMDAR and BDNF -TrkB signaling increases in peripheral lymphocyte receptor, intracellular mediators, and the downstream level.

The decrements in the Unified Parkinson’s Disease Rating Scale II (UPDRSII) and total scores were significantly correlated with the increase in receptor TrkB signaling, intracellular mediators, and the level of interaction of NMDAR. Conclusion The significant correlation between reduced UPDRS score and change the activity of lymphocytes demonstrated that improved BDNF -TrkB signaling in lymphocytes and reduce the severity of symptoms of PD may be related.

Intensive Rehabilitation Enhances Lymphocyte BDNF-TrkB Signaling in Patients With Parkinson's Disease.
Intensive Rehabilitation Enhances Lymphocyte BDNF-TrkB Signaling in Patients With Parkinson’s Disease.

Late pulses like receptor 4 inversely attenuating the effects of Chinese herbal Xiao-Qing-Long-Tang on allergen-induced nerve growth factor and thymic stromal lymphopoietin.4

Xiao-Qing-Long-Tang (XQLT) is known to regulate the immune allergic reaction. The purpose of this study was to investigate the effects of XQLT on allergen-induced cytokine and related signaling pathways. A rat model of acute allergic used to investigate the effects of XQLT on nerve growth factor (NGF) during an allergic reaction, while Human pulmonary alveolar epithelial cells (HPAEpiCs) was used to investigate the effects of XQLT on Dermatophagoides pteronyssinus group 2 ( der p 2) -induced NGF, p75 neurotrophin receptor (p75NTR) and thymic stromal lymphopoietin (TSLP) expression. XQLT shown to inhibit allergic reactions associated NGF- and p75NTR in a mouse model.

XQLT also reduce the expression of Toll-like receptor 4 (TLR 4 ) in the lungs of rat models. XQLT inhibit Der p 2-induced NGF, TSLP and p75NTR expression in cell lines HPAEpiC. The use recombinant TLR soluble 4 (sTLR 4 ) in the competitive test XQLT partially attenuated inhibitory effect on NGF, TSLP and p75NTR expression in HPAEpiC cells. XQLT inhibitory effect on Ser536 phosphorylation of p65 (nuclear factor-kB; NF-kB), a TLR 4 the impact factor, is also attenuated by sTLR 4 .

Neurotrophin-4 (NTF4) Antibody

20-abx137025
  • EUR 356.00
  • EUR 523.00
  • 0.5 mg
  • 1 mg

Neurotrophin 4 (NTF4) Antibody

20-abx001004
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Neurotrophin 4 (NTF4) Antibody

abx235682-100ug 100 ug
EUR 481

Neurotrophin 4 (NTF4) Antibody

20-abx241784
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul

Neurotrophin 4 (NTF4) Antibody

20-abx326456
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug

Human Neurotrophin 4 (NTF4) Protein

20-abx262207
  • EUR 328.00
  • EUR 5826.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg

Human NTF4/ Neurotrophin-4 ELISA Kit

E2816Hu 1 Kit
EUR 571

Human Neurotrophin 4 (NTF4) ELISA Kit

abx575476-96tests 96 tests
EUR 707

Human Neurotrophin 4 (NTF4) ELISA Kit

abx050177-96tests 96 tests
EUR 652

Human Neurotrophin 4 (NTF4) ELISA Kit

20-abx152512
  • EUR 6642.00
  • EUR 3542.00
  • EUR 825.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Neurotrophin 4 (NTF4) ELISA Kit

abx251825-96tests 96 tests
EUR 707

Rat Ntf4/ Neurotrophin-4 ELISA Kit

E0702Ra 1 Kit
EUR 571

Mouse Neurotrophin 4 (NTF4) ELISA Kit

abx574572-96tests 96 tests
EUR 707

Rat Neurotrophin 4 (NTF4) ELISA Kit

abx575477-96tests 96 tests
EUR 707

Sheep Neurotrophin 4 (NTF4) ELISA Kit

abx364700-96tests 96 tests
EUR 926

Monkey Neurotrophin 4 (NTF4) ELISA Kit

abx360359-96tests 96 tests
EUR 825

Pig Neurotrophin 4 (NTF4) ELISA Kit

abx362091-96tests 96 tests
EUR 825

Rabbit Neurotrophin 4 (NTF4) ELISA Kit

abx362259-96tests 96 tests
EUR 825

Chicken Neurotrophin 4 (NTF4) ELISA Kit

abx356910-96tests 96 tests
EUR 825

Rat Neurotrophin 4 (NTF4) ELISA Kit

abx050178-96tests 96 tests
EUR 652

Mouse Neurotrophin 4 (NTF4) ELISA Kit

abx050179-96tests 96 tests
EUR 652

Mouse Neurotrophin 4 (NTF4) ELISA Kit

abx254300-96tests 96 tests
EUR 707

Rat Neurotrophin 4 (NTF4) ELISA Kit

20-abx155889
  • EUR 7237.00
  • EUR 3855.00
  • EUR 895.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Neurotrophin 4 (NTF4) ELISA Kit

20-abx154459
  • EUR 6642.00
  • EUR 3542.00
  • EUR 825.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Rat Neurotrophin 4 (NTF4) ELISA Kit

abx255863-96tests 96 tests
EUR 707

Recombinant Human Neurotrophin-4

7-01303 2µg Ask for price

Recombinant Human Neurotrophin-4

7-01304 10µg Ask for price

Recombinant Human Neurotrophin-4

7-01305 1mg Ask for price

Recombinant Neurotrophin 4 (NT4)

4-RPA107Hu01
  • EUR 512.16
  • EUR 240.00
  • EUR 1645.60
  • EUR 615.20
  • EUR 1130.40
  • EUR 406.00
  • EUR 3964.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Neurotrophin 4 expressed in: E.coli

Recombinant Neurotrophin 4 (NT4)

4-RPA107Mu01
  • EUR 501.41
  • EUR 237.00
  • EUR 1605.28
  • EUR 601.76
  • EUR 1103.52
  • EUR 398.00
  • EUR 3863.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Neurotrophin 4 expressed in: E.coli

NT-4 Neurotrophin-4 Human Recombinant Protein

PROTP34130 Regular: 10ug
EUR 317
Description: Neurotrophin-4 Human Recombinant produced in E.Coli is a noncovalently linked homodimer, non-glycosylated polypeptide chain containing 2 x 130 amino acids (81-210 amino acids) and having a total molecular mass of 28 kDa. ;The NT-4 is purified by proprietary chromatographic techniques.

NT-4, Neurotrophin-4, human

RC218-15 2ug
EUR 104.38

anti-Neurotrophin 4

YF-PA13491 50 ul
EUR 363
Description: Mouse polyclonal to Neurotrophin 4

anti-Neurotrophin 4

YF-PA13492 100 ul
EUR 403
Description: Rabbit polyclonal to Neurotrophin 4

anti-Neurotrophin 4

YF-PA13493 100 ug
EUR 403
Description: Rabbit polyclonal to Neurotrophin 4

anti-Neurotrophin 4

YF-PA24273 50 ul
EUR 334
Description: Mouse polyclonal to Neurotrophin 4

IL-4 Interleukin 4 Human Recombinant Protein, Yeast

PROTP05112-4 Regular: 10ug
EUR 317
Description: Interleukin-4 Human Recombinant produced in yeast is a single, glycosylated polypeptide chain containing 129 amino acids.;The IL-4 is purified by proprietary chromatographic techniques.

Recombinant Human 4-1BB Receptor Protein

PROTQ07011-4 20ug
EUR 317
Description: 4-1BB Receptor, a member of the TNF superfamily of receptors, is mainly expressed on the surface of a variety of T cells, but also found in B cells, monocytes, and various transformed cell lines. 4-1BB Receptor binds to 4-1BBL to provide a co-stimulatory signal for T lymphocytes. Signaling by 4-1BB Receptor has been implicated in the antigen-presentation process and generation of cytotoxic T cells. The human 4-1BB Receptor gene codes for a 255 amino acid type I transmembrane protein containing a 17 amino acid N-terminal signal sequence, a 169 amino acid extracellular domain, a 27 amino acid transmembrane domain and a 42 amino acid cytoplasmic domain. Recombinant human soluble 4-1BB Receptor is a 167 amino acid polypeptide (17.7 kDa), which contains the cysteine rich TNFR-like extracellular domain of 4-1BB Receptor.

Recombinant Human PF-4 (CXCL4) Protein

PROTP02776-4 20ug
EUR 317
Description: PF-4 is a CXC chemokine that is expressed in megakaryocytes and stored in the α-granules of platelets. PF-4 is chemotactic towards neutrophils and monocytes and has been shown to inhibit angiogenesis. Recombinant human PF-4 is a 7.8 kDa protein containing 70 amino acid residues, including the four highly conserved residues present in CXC chemokines.

Human Neurotrophin 4 (NT4) Protein

20-abx167127
  • EUR 718.00
  • EUR 286.00
  • EUR 2221.00
  • EUR 857.00
  • EUR 509.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Neurotrophin 4 ELISA kit

E01N0019-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Human Neurotrophin 4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Neurotrophin 4 ELISA kit

E01N0019-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Human Neurotrophin 4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Neurotrophin 4 ELISA kit

E01N0019-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Human Neurotrophin 4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Neurotrophin 4 ELISA kit

E01N0107-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Human Neurotrophin 4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Neurotrophin 4 ELISA kit

E01N0107-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Human Neurotrophin 4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Neurotrophin 4 ELISA kit

E01N0107-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Human Neurotrophin 4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Neurotrophin 4 ELISA kit

55R-2076 96 tests
EUR 712
Description: ELISA Kit for detection of Neurotrophin 4 in the research laboratory

Human Neurotrophin 4, NT-4 ELISA KIT

CSB-E04689h-24T 1 plate of 24 wells
EUR 165
Description: Quantitativesandwich ELISA kit for measuring Human Neurotrophin 4, NT-4 in samples from serum, plasma, cell culture supernates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Neurotrophin 4, NT-4 ELISA KIT

1-CSB-E04689h
  • EUR 574.00
  • EUR 4013.00
  • EUR 2138.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Neurotrophin 4, NT-4 in samples from serum, plasma, cell culture supernates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Neurotrophin 4(NT-4)ELISA Kit

GA-E1309HM-48T 48T
EUR 289

Human Neurotrophin 4(NT-4)ELISA Kit

GA-E1309HM-96T 96T
EUR 466

Human Neurotrophin 4,NT-4 ELISA KIT

201-12-1293 96 tests
EUR 440
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Neurotrophin 4 (NT-4) CLIA Kit

abx197346-96tests 96 tests
EUR 825

Human Neurotrophin 4(NT-4)ELISA Kit

QY-E01633 96T
EUR 361

Human NT-4(Neurotrophin-4) ELISA Kit

EH0246 96T
EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 56.25pg/ml

Human Neurotrophin 4,NT-4 ELISA KIT

CN-03258H1 96T
EUR 438

Human Neurotrophin 4,NT-4 ELISA KIT

CN-03258H2 48T
EUR 289

Neurotrophin 4 (NT4) Antibody

20-abx128671
  • EUR 398.00
  • EUR 133.00
  • EUR 1107.00
  • EUR 537.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Neurotrophin 4 Antibody (HRP)

20-abx108554
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Neurotrophin 4 (NT4) Antibody

20-abx101106
  • EUR 411.00
  • EUR 133.00
  • EUR 1135.00
  • EUR 551.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Neurotrophin 4 (NT4) Antibody

20-abx177798
  • EUR 1135.00
  • EUR 551.00
  • 1 mg
  • 200 ug

Neurotrophin 4 (NT4) Antibody

20-abx177799
  • EUR 1177.00
  • EUR 578.00
  • 1 mg
  • 200 ug

Neurotrophin 4 (NT4) Antibody

20-abx173809
  • EUR 787.00
  • EUR 411.00
  • 1 mg
  • 200 ug

Neurotrophin 4 (NT4) Antibody

20-abx173810
  • EUR 843.00
  • EUR 439.00
  • 1 mg
  • 200 ug

Neurotrophin-4 Polyclonal Antibody

42517-100ul 100ul
EUR 333

anti- Neurotrophin 4 antibody

FNab05682 100µg
EUR 505.25
Description: Antibody raised against Neurotrophin 4

Anti-Neurotrophin 4 antibody

PAab05682 100 ug
EUR 355

Anti-Neurotrophin 4 (1G12)

YF-MA14522 100 ug
EUR 363
Description: Mouse monoclonal to Neurotrophin 4

NT-4 (Neurotrophin-4) GMP, CF

PR15132CF 5 ug
EUR 610

Feline IL-4 Recombinant Protein

R00230-4 5ug/vial
EUR 259
Description: IL-4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of CD4+ T-cells into Th2 cells. It is a key regulator in humoral and adaptive immunity. Feline IL-4 Recombinant Protein is purified interleukin-4 produced in yeast.

Human Neurotrophin 4 (NT4) ELISA Kit

SEA107Hu-10x96wellstestplate 10x96-wells test plate
EUR 4273.35
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Neurotrophin 4 (NT4) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Neurotrophin 4 (NT4) ELISA Kit

SEA107Hu-1x48wellstestplate 1x48-wells test plate
EUR 439.57
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Neurotrophin 4 (NT4) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Neurotrophin 4 (NT4) ELISA Kit

SEA107Hu-1x96wellstestplate 1x96-wells test plate
EUR 585.1
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Neurotrophin 4 (NT4) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Neurotrophin 4 (NT4) ELISA Kit

SEA107Hu-5x96wellstestplate 5x96-wells test plate
EUR 2332.95
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Neurotrophin 4 (NT4) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Neurotrophin 4 (NT4) ELISA Kit

4-SEA107Hu
  • EUR 4324.00
  • EUR 2283.00
  • EUR 586.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Neurotrophin 4 (NT4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species.

Neurotrophin 4 (NT4) Polyclonal Antibody (Human)

4-PAA107Hu01
  • EUR 232.00
  • EUR 2285.00
  • EUR 574.00
  • EUR 289.00
  • EUR 208.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Neurotrophin 4 (NT4)

Human Neurotrophin 4 (NT4) ELISA Kit

RD-NT4-Hu-48Tests 48 Tests
EUR 478

Human Neurotrophin 4 (NT4) ELISA Kit

RD-NT4-Hu-96Tests 96 Tests
EUR 662

Human Neurotrophin 4 (NT4) ELISA Kit

DLR-NT4-Hu-48T 48T
EUR 479
Description: A sandwich quantitative ELISA assay kit for detection of Human Neurotrophin 4 (NT4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Neurotrophin 4 (NT4) ELISA Kit

DLR-NT4-Hu-96T 96T
EUR 621
Description: A sandwich quantitative ELISA assay kit for detection of Human Neurotrophin 4 (NT4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Neurotrophin 4 (NT4) Protein (Active)

20-abx655787
  • EUR 1149.00
  • EUR 411.00
  • EUR 3850.00
  • EUR 1400.00
  • EUR 787.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Neurotrophin 4 (NT4) CLIA Kit

20-abx491029
  • EUR 7973.00
  • EUR 4246.00
  • EUR 981.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Neurotrophin 4 ELISA Kit (NT4)

RK01969 96 Tests
EUR 521

Human Neurotrophin 4 (NT4) ELISA Kit

RDR-NT4-Hu-48Tests 48 Tests
EUR 500

Human Neurotrophin 4 (NT4) ELISA Kit

RDR-NT4-Hu-96Tests 96 Tests
EUR 692

ELISA kit for Human Neurotrophin-4

EK1291 96 tests
EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Neurotrophin-4 in samples from serum, plasma, tissue homogenates and other biological fluids.

CLIA kit for Human NT-4 (Neurotrophin 4)

E-CL-H1172 1 plate of 96 wells
EUR 584
Description: A sandwich CLIA kit for quantitative measurement of Human NT-4 (Neurotrophin 4) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human NT-4 (Neurotrophin 4)

E-EL-H1897 1 plate of 96 wells
EUR 534
Description: A sandwich ELISA kit for quantitative measurement of Human NT-4 (Neurotrophin 4) in samples from Serum, Plasma, Cell supernatant

Recombinant Human Neurotrophin-3

7-01294 2µg Ask for price

Recombinant Human Neurotrophin-3

7-01295 10µg Ask for price

Recombinant Human Neurotrophin-3

7-01296 1mg Ask for price

Rat Neurotrophin 4 (NT4) Protein

20-abx654553
  • EUR 746.00
  • EUR 300.00
  • EUR 2346.00
  • EUR 899.00
  • EUR 537.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Neurotrophin 4 (NT4) Protein

20-abx068272
  • EUR 704.00
  • EUR 286.00
  • EUR 2165.00
  • EUR 829.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Neurotrophin-4 Polyclonal Conjugated Antibody

C42517 100ul
EUR 397

In conclusion, XQLT hampered Der p allergen-induced NGF, p75NTR and TSLP expression. This inhibition is attenuated by sTLR 4 . The working mechanism of XQLT may be correlated with TLR 4 , the main receptors in the innate immune system. The findings of this study can focus on the pharmacological target search XQLT to TLR 4 , which is important in the presentation of allergens path.