Background In the animal combined and Human study, we have previously found that treatment of 5-day increase the plasticity of cortical also facilitates brain – derived neurotrophic factor ( BDNF ) – receptor tyrosine kinase B (TrkB) signaling and increased activated TrkB and N-methyl-d-aspartate receptor (NMDAR) association in both the cortex and peripheral lymphocytes.

Patients with Parkinson’s disease (PD), in general, show decreased cortical plasticity, as shown by electrophysiological and behavioral studies. Here, we tested the hypothesis that exercise programs that improve motor function and appears to slow the progression of symptoms can improve BDNF -TrkB signals in lymphocytes. Methods A total of 16 patients with PD experience 4 -week intensive multidisciplinary rehabilitation treatment (MIRT), which includes aerobic exercise and physical and occupational therapy.

Blood was collected before and after 2 and 4 MIRT week. Lymphocytes isolated to check the BDNF -TrkB signaling caused by incubation with recombinant Human BDNF . TrkB signaling complex, extracellular-signal-regulated kinase-2 and protein-kinase-B immunoprecipitated; immunocomplexes contents determined by Western blotting. Results After MIRT, all patients showed improvements in motor function. TrkB interaction with NMDAR and BDNF -TrkB signaling increases in peripheral lymphocyte receptor, intracellular mediators, and the downstream level.

The decrements in the Unified Parkinson’s Disease Rating Scale II (UPDRSII) and total scores were significantly correlated with the increase in receptor TrkB signaling, intracellular mediators, and the level of interaction of NMDAR. Conclusion The significant correlation between reduced UPDRS score and change the activity of lymphocytes demonstrated that improved BDNF -TrkB signaling in lymphocytes and reduce the severity of symptoms of PD may be related.

Intensive Rehabilitation Enhances Lymphocyte BDNF-TrkB Signaling in Patients With Parkinson's Disease.
Intensive Rehabilitation Enhances Lymphocyte BDNF-TrkB Signaling in Patients With Parkinson’s Disease.

Late pulses like receptor 4 inversely attenuating the effects of Chinese herbal Xiao-Qing-Long-Tang on allergen-induced nerve growth factor and thymic stromal lymphopoietin.4

Xiao-Qing-Long-Tang (XQLT) is known to regulate the immune allergic reaction. The purpose of this study was to investigate the effects of XQLT on allergen-induced cytokine and related signaling pathways. A rat model of acute allergic used to investigate the effects of XQLT on nerve growth factor (NGF) during an allergic reaction, while Human pulmonary alveolar epithelial cells (HPAEpiCs) was used to investigate the effects of XQLT on Dermatophagoides pteronyssinus group 2 ( der p 2) -induced NGF, p75 neurotrophin receptor (p75NTR) and thymic stromal lymphopoietin (TSLP) expression. XQLT shown to inhibit allergic reactions associated NGF- and p75NTR in a mouse model.

XQLT also reduce the expression of Toll-like receptor 4 (TLR 4 ) in the lungs of rat models. XQLT inhibit Der p 2-induced NGF, TSLP and p75NTR expression in cell lines HPAEpiC. The use recombinant TLR soluble 4 (sTLR 4 ) in the competitive test XQLT partially attenuated inhibitory effect on NGF, TSLP and p75NTR expression in HPAEpiC cells. XQLT inhibitory effect on Ser536 phosphorylation of p65 (nuclear factor-kB; NF-kB), a TLR 4 the impact factor, is also attenuated by sTLR 4 .

Recombinant Human Neurotrophin-4 (NTF4), partial
CSB-EP016121HU1 1830 mg Ask for price

Recombinant Human Neurotrophin-4 (NTF4), partial
CSB-EP016121HU1-100ug 100ug Ask for price
Description: 82-210aa

Recombinant Human Neurotrophin-4 (NTF4), partial
CSB-EP016121HU1-1mg 1mg Ask for price
Description: 82-210aa

Recombinant Human Neurotrophin-4 (NTF4), partial
CSB-EP016121HU1-20ug 20ug Ask for price
Description: 82-210aa

Recombinant Human Neurotrophin-4 protein (NTF4)
MBS9423137-001mg 0.01mg
EUR 365

Recombinant Human Neurotrophin-4 protein (NTF4)
MBS9423137-01mg 0.1mg
EUR 1925

Recombinant Human Neurotrophin-4 protein (NTF4)
MBS9423137-025mg 0.25mg
EUR 3385

Recombinant Human Neurotrophin-4 protein (NTF4)
MBS9423137-05mg 0.5mg
EUR 4375

Recombinant Human Neurotrophin-4 protein (NTF4)
MBS9423137-1mg 1mg
EUR 5920

Recombinant Rat Neurotrophin-4 (Ntf4)
MBS953076-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1050

Recombinant Rat Neurotrophin-4 (Ntf4)
MBS953076-002mgEColi 0.02mg(E-Coli)
EUR 635

Recombinant Rat Neurotrophin-4 (Ntf4)
MBS953076-002mgYeast 0.02mg(Yeast)
EUR 805

Recombinant Rat Neurotrophin-4 (Ntf4)
MBS953076-01mgEColi 0.1mg(E-Coli)
EUR 735

Recombinant Rat Neurotrophin-4 (Ntf4)
MBS953076-01mgYeast 0.1mg(Yeast)
EUR 940

Recombinant Human Neurotrophin-4 protein (NTF4) (Active)
CSB-AP002831HU 8451 mg Ask for price

Recombinant Human Neurotrophin-4 protein (NTF4) (Active)
CSB-AP002831HU-100ug 100ug Ask for price
Description: 81-210aa

Recombinant Human Neurotrophin-4 protein (NTF4) (Active)
CSB-AP002831HU-10ug 10ug Ask for price
Description: 81-210aa

Recombinant Human Neurotrophin-4 protein (NTF4) (Active)
CSB-AP002831HU-500ug 500ug Ask for price
Description: 81-210aa

Recombinant Human Neurotrophin-4 protein(NTF4) (Active)
AP73547 1mg
EUR 6829

Recombinant Human Neurotrophin-4 protein (NTF4) (Active)
MBS969401-001mg 0.01mg
EUR 355

Recombinant Human Neurotrophin-4 protein (NTF4) (Active)
MBS969401-01mg 0.1mg
EUR 1590

Recombinant Human Neurotrophin-4 protein (NTF4) (Active)
MBS969401-05mg 0.5mg
EUR 3395

Recombinant Human Neurotrophin-4 protein (NTF4) (Active)
MBS969401-5x05mg 5x0.5mg
EUR 15240

Recombinant Mouse Neurotrophin-4 (Ntf4)
MBS1428509-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1050

Recombinant Mouse Neurotrophin-4 (Ntf4)
MBS1428509-002mgEColi 0.02mg(E-Coli)
EUR 635

Recombinant Mouse Neurotrophin-4 (Ntf4)
MBS1428509-002mgYeast 0.02mg(Yeast)
EUR 805

Recombinant Mouse Neurotrophin-4 (Ntf4)
MBS1428509-01mgEColi 0.1mg(E-Coli)
EUR 735

Recombinant Mouse Neurotrophin-4 (Ntf4)
MBS1428509-01mgYeast 0.1mg(Yeast)
EUR 940

NTF4 (untagged)-Human neurotrophin 4 (NTF4)
SC122741 10 µg Ask for price

Human Neurotrophin-4 (NTF4)
1-CSB-RP099294h
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Description: Recombinant Human Neurotrophin-4(NTF4) expressed in E.coli

Recombinant Xenopus laevis Neurotrophin-4 (ntf4)
MBS1021826-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1045

Recombinant Xenopus laevis Neurotrophin-4 (ntf4)
MBS1021826-002mgEColi 0.02mg(E-Coli)
EUR 625

Recombinant Xenopus laevis Neurotrophin-4 (ntf4)
MBS1021826-002mgYeast 0.02mg(Yeast)
EUR 800

Recombinant Xenopus laevis Neurotrophin-4 (ntf4)
MBS1021826-01mgEColi 0.1mg(E-Coli)
EUR 725

Recombinant Xenopus laevis Neurotrophin-4 (ntf4)
MBS1021826-01mgYeast 0.1mg(Yeast)
EUR 935

NTF4 (GFP-tagged) - Human neurotrophin 4 (NTF4)
RG204535 10 µg Ask for price

Recombinant Macrovipera lebetina Neurotrophin-4 (NTF4)
MBS1256872-002mgBaculovirus 0.02mg(Baculovirus)
EUR 970

Recombinant Macrovipera lebetina Neurotrophin-4 (NTF4)
MBS1256872-002mgEColi 0.02mg(E-Coli)
EUR 525

Recombinant Macrovipera lebetina Neurotrophin-4 (NTF4)
MBS1256872-002mgYeast 0.02mg(Yeast)
EUR 720

Recombinant Macrovipera lebetina Neurotrophin-4 (NTF4)
MBS1256872-01mgEColi 0.1mg(E-Coli)
EUR 625

Recombinant Macrovipera lebetina Neurotrophin-4 (NTF4)
MBS1256872-01mgYeast 0.1mg(Yeast)
EUR 845

Human Neurotrophin 4 (NTF4) Protein
abx262207-10mg 10 mg
EUR 325

Human Neurotrophin 4 (NTF4) Protein
20-abx262207
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Human Neurotrophin 4 (NTF4) Protein
abx262207-25mg 25 mg
EUR 5975

Human Neurotrophin 4 (NTF4) Protein
abx262207-5mg 5 mg
EUR 225

NTF4 (Myc-DDK-tagged)-Human neurotrophin 4 (NTF4)
RC204535 10 µg Ask for price

Human Neurotrophin 4 (NTF4) CLIA Kit
abx197346-100l 100 µl Ask for price

Human Neurotrophin 4 (NTF4) CLIA Kit
abx197346-50l 50 µl
EUR 618.75

Human Neurotrophin 4 (NTF4) CLIA Kit
20-abx491029
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  • 96 tests
  • 5 × 96 tests
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Human Neurotrophin 4 (NTF4) ELISA Kit
abx050177-96tests 96 tests
EUR 782.4

Human Neurotrophin 4 (NTF4) ELISA Kit
20-abx152512
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  • 96 tests
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Human Neurotrophin 4 (NTF4) ELISA Kit
abx575476-96tests 96 tests
EUR 848.4

Human Neurotrophin 4 (NTF4) ELISA Kit
abx251825-96tests 96 tests
EUR 525

Human NTF4/ Neurotrophin-4 ELISA Kit
E2816Hu 1 Kit
EUR 515
Description: NTF5,Neurotrophin-5,Neutrophic factor 4,NT-5

Human NTF4/Neurotrophin-4 ELISA Kit
E45K00542 96T
EUR 1008.85

Neurotrophin 4 (NTF4) Antibody
abx002282-100l 100 µl
EUR 400

Neurotrophin 4 (NTF4) Antibody
20-abx002282
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Neurotrophin 4 (NTF4) Antibody
abx002282-20l 20 µl
EUR 175

Neurotrophin 4 (NTF4) Antibody
abx002282-50l 50 µl
EUR 275

Neurotrophin 4 (NTF4) Antibody
abx001004-100l 100 µl
EUR 400

Neurotrophin 4 (NTF4) Antibody
20-abx001004
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Neurotrophin 4 (NTF4) Antibody
abx001004-20l 20 µl
EUR 175

Neurotrophin 4 (NTF4) Antibody
abx001004-50l 50 µl
EUR 275

Neurotrophin 4 (NTF4) Antibody
abx114093-100l 100 µl
EUR 612.5

Neurotrophin 4 (NTF4) Antibody
20-abx114093
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  • 50 ul
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Neurotrophin 4 (NTF4) Antibody
abx110042-100l 100 µl
EUR 162.5

Neurotrophin 4 (NTF4) Antibody
20-abx110042
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  • 20 ug
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Neurotrophin 4 (NTF4) Antibody
20-abx142109
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Neurotrophin 4 (NTF4) Antibody
abx145494-100ug 100 ug
EUR 469.2

Neurotrophin 4 (NTF4) Antibody
abx145494-1096tests 10 × 96 tests Ask for price

Neurotrophin 4 (NTF4) Antibody
abx145494-596tests 5 × 96 tests Ask for price

Neurotrophin 4 (NTF4) Antibody
abx145494-96tests 96 tests
EUR 337.5

Neurotrophin 4 (NTF4) Antibody
abx326456-100g 100 µg
EUR 250

Neurotrophin 4 (NTF4) Antibody
20-abx326456
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Neurotrophin 4 (NTF4) Antibody
abx326456-50g 50 µg
EUR 187.5

Neurotrophin 4 (NTF4) Antibody
20-abx241784
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Neurotrophin 4 (NTF4) Antibody
abx241784-96tests 96 tests
EUR 250

Neurotrophin 4 (NTF4) Antibody
abx235682-100g 100 µg
EUR 350

Neurotrophin 4 (NTF4) Antibody
abx235682-100ug 100 ug
EUR 577.2

Neurotrophin-4 (NTF4) Antibody
abx137025-01mg 0.1 mg
EUR 487.5

Neurotrophin-4 (NTF4) Antibody
20-abx137025
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Neurotrophin 4 (NTF4) (NM_006179) Human Over-expression Lysate
E45H08070-2 each
EUR 395

Neurotrophin 4 (NTF4) (NM_006179) Human Over-expression Lysate
LS004909 100ug
EUR 628
Description: Transient overexpression lysate of neurotrophin 4 (NTF4)

NT-4 (Neurotrophin 4, Neurotrophin-4, NT4, Neutrophic Factor 4, NTF4, Neurotrophin 4/5, NT-4/5, NTF4/5, Neurotrophin 5, Neurotrophin-5, NT5, NT-5, Neutrophic Factor 5, NTF5)
MBS615657-05mg 0.5mg
EUR 650

NT-4 (Neurotrophin 4, Neurotrophin-4, NT4, Neutrophic Factor 4, NTF4, Neurotrophin 4/5, NT-4/5, NTF4/5, Neurotrophin 5, Neurotrophin-5, NT5, NT-5, Neutrophic Factor 5, NTF5)
MBS615657-5x05mg 5x0.5mg
EUR 2780

NT-4 (Neurotrophin 4, Neurotrophin-4, NT4, Neutrophic Factor 4, NTF4, Neurotrophin 4/5, NT-4/5, NTF4/5, Neurotrophin 5, Neurotrophin-5, NT5, NT-5, Neutrophic Factor 5, NTF5)
MBS610753-05mg 0.5mg
EUR 650

NT-4 (Neurotrophin 4, Neurotrophin-4, NT4, Neutrophic Factor 4, NTF4, Neurotrophin 4/5, NT-4/5, NTF4/5, Neurotrophin 5, Neurotrophin-5, NT5, NT-5, Neutrophic Factor 5, NTF5)
MBS610753-5x05mg 5x0.5mg
EUR 2780

NT-4 (Neurotrophin 4, Neurotrophin-4, NT4, Neutrophic Factor 4, NTF4, Neurotrophin 4/5, NT-4/5, NTF4/5, Neurotrophin 5, Neurotrophin-5, NT5, NT-5, Neutrophic Factor 5, NTF5)
MBS617214-01mL 0.1mL
EUR 650

NT-4 (Neurotrophin 4, Neurotrophin-4, NT4, Neutrophic Factor 4, NTF4, Neurotrophin 4/5, NT-4/5, NTF4/5, Neurotrophin 5, Neurotrophin-5, NT5, NT-5, Neutrophic Factor 5, NTF5)
MBS617214-5x01mL 5x0.1mL
EUR 2780

NT-4 (Neurotrophin 4, Neurotrophin-4, NT4, Neutrophic Factor 4, NTF4, Neurotrophin 4/5, NT-4/5, NTF4/5, Neurotrophin 5, Neurotrophin-5, NT5, NT-5, Neutrophic Factor 5, NTF5)
MBS618954-01mL 0.1mL
EUR 650

NT-4 (Neurotrophin 4, Neurotrophin-4, NT4, Neutrophic Factor 4, NTF4, Neurotrophin 4/5, NT-4/5, NTF4/5, Neurotrophin 5, Neurotrophin-5, NT5, NT-5, Neutrophic Factor 5, NTF5)
MBS618954-5x01mL 5x0.1mL
EUR 2780

NTF4 (Neurotrophin 4, Neurotrophin-4, NT-4/5, NT4, NT5, NTF5) (AP)
MBS6429785-01mL 0.1mL
EUR 950

NTF4 (Neurotrophin 4, Neurotrophin-4, NT-4/5, NT4, NT5, NTF5) (AP)
MBS6429785-5x01mL 5x0.1mL
EUR 4120

NTF4 (Neurotrophin 4, Neurotrophin-4, NT-4/5, NT4, NT5, NTF5) (PE)
MBS6429795-01mL 0.1mL
EUR 950

NTF4 (Neurotrophin 4, Neurotrophin-4, NT-4/5, NT4, NT5, NTF5) (PE)
MBS6429795-5x01mL 5x0.1mL
EUR 4120

NTF4 (Neurotrophin 4, Neurotrophin-4, NT-4/5, NT4, NT5, NTF5) (AP)
MBS6429796-01mL 0.1mL
EUR 950

NTF4 (Neurotrophin 4, Neurotrophin-4, NT-4/5, NT4, NT5, NTF5) (AP)
MBS6429796-5x01mL 5x0.1mL
EUR 4120

NTF4 (Neurotrophin 4, Neurotrophin-4, NT-4/5, NT4, NT5, NTF5) (PE)
MBS6429806-01mL 0.1mL
EUR 950

NTF4 (Neurotrophin 4, Neurotrophin-4, NT-4/5, NT4, NT5, NTF5) (PE)
MBS6429806-5x01mL 5x0.1mL
EUR 4120

NTF4 (Neurotrophin 4, Neurotrophin-4, NT-4/5, NT4, NT5, NTF5) (APC)
MBS6429786-01mL 0.1mL
EUR 950

NTF4 (Neurotrophin 4, Neurotrophin-4, NT-4/5, NT4, NT5, NTF5) (APC)
MBS6429786-5x01mL 5x0.1mL
EUR 4120

NTF4 (Neurotrophin 4, Neurotrophin-4, NT-4/5, NT4, NT5, NTF5) (HRP)
MBS6429789-01mL 0.1mL
EUR 950

NTF4 (Neurotrophin 4, Neurotrophin-4, NT-4/5, NT4, NT5, NTF5) (HRP)
MBS6429789-5x01mL 5x0.1mL
EUR 4120

NTF4 (Neurotrophin 4, Neurotrophin-4, NT-4/5, NT4, NT5, NTF5) (APC)
MBS6429797-01mL 0.1mL
EUR 950

NTF4 (Neurotrophin 4, Neurotrophin-4, NT-4/5, NT4, NT5, NTF5) (APC)
MBS6429797-5x01mL 5x0.1mL
EUR 4120

NTF4 (Neurotrophin 4, Neurotrophin-4, NT-4/5, NT4, NT5, NTF5) (HRP)
MBS6429800-01mL 0.1mL
EUR 950

NTF4 (Neurotrophin 4, Neurotrophin-4, NT-4/5, NT4, NT5, NTF5) (HRP)
MBS6429800-5x01mL 5x0.1mL
EUR 4120

Recombinant Human Neurotrophin-3 (NTF3)
CSB-BP016120HU 7886 mg Ask for price

Recombinant Human Neurotrophin-3 (NTF3)
CSB-BP016120HU-100ug 100ug Ask for price
Description: 139-257aa

Recombinant Human Neurotrophin-3 (NTF3)
CSB-BP016120HU-1mg 1mg Ask for price
Description: 139-257aa

Recombinant Human Neurotrophin-3 (NTF3)
CSB-BP016120HU-20ug 20ug Ask for price
Description: 139-257aa

Recombinant Human Neurotrophin-3 (NTF3)
CSB-MP016120HU 7843 mg Ask for price

Recombinant Human Neurotrophin-3 (NTF3)
CSB-MP016120HU-100ug 100ug Ask for price
Description: 139-257aa

Recombinant Human Neurotrophin-3 (NTF3)
CSB-MP016120HU-1mg 1mg Ask for price
Description: 139-257aa

Recombinant Human Neurotrophin-3 (NTF3)
CSB-MP016120HU-20ug 20ug Ask for price
Description: 139-257aa

Recombinant Human Neurotrophin-3 (NTF3)
CSB-EP016120HU 7990 mg Ask for price

Recombinant Human Neurotrophin-3 (NTF3)
CSB-EP016120HU-100ug 100ug Ask for price
Description: 139-257aa

Recombinant Human Neurotrophin-3 (NTF3)
CSB-EP016120HU-1mg 1mg Ask for price
Description: 139-257aa

Recombinant Human Neurotrophin-3 (NTF3)
CSB-EP016120HU-20ug 20ug Ask for price
Description: 139-257aa

Recombinant Human Neurotrophin-3 (NTF3)
MBS7114977-001mg 0.01mg
EUR 310

Recombinant Human Neurotrophin-3 (NTF3)
MBS7114977-005mg 0.05mg
EUR 720

Recombinant Human Neurotrophin-3 (NTF3)
MBS7114977-5x005mg 5x0.05mg
EUR 3045

Recombinant Human Neurotrophin-3 (NTF3)
MBS954371-002mgBaculovirus 0.02mg(Baculovirus)
EUR 390

Recombinant Human Neurotrophin-3 (NTF3)
MBS954371-002mgEColi 0.02mg(E-Coli)
EUR 280

In conclusion, XQLT hampered Der p allergen-induced NGF, p75NTR and TSLP expression. This inhibition is attenuated by sTLR 4 . The working mechanism of XQLT may be correlated with TLR 4 , the main receptors in the innate immune system. The findings of this study can focus on the pharmacological target search XQLT to TLR 4 , which is important in the presentation of allergens path.