transient receptor potential canonical (TRPC) proteins form Ca (2 +) – permeable cation channel activated on stimulation of metabotropic receptors coupled to phospholipase C. Among the subfamily TRPC, TRPC3 and TRPC6 channel directly activated by diacylglycerol (DAG) plays an important role in < em> brain – derived neurotrophic factor ( BDNF ) signals, promoting the development of neuronal and survival , In various disease models, BDNF to restore neurological deficit, but its therapeutic potential is limited by poor pharmacokinetic profiles.
Explanation framework for designing small molecules, which Stirs BDNF -like activity through TRPC3 and TRPC6, establish a solid basis to overcome these limitations. We found, through the screening of the library, a group of piperazine- derived a compound that activates a DAG-activated TRPC3 / TRPC6 / TRPC7 channels. Compound 4 – (5-chloro-2-methylphenyl) piperazine-1-yl methanone (PPZ1) and 2 – [ 4 – (2 , 3-dimethylphenyl) piperazine-1-yl] -N- (2-ethoxyphenyl) acetamide (PPZ2) is activated, dose-dependent manner, recombinant TRPC3 / TRPC6 / TRPC7 channels, but no other TRPCs, The human embryonic kidney cells. PPZ2 activated TRPC6 as the original channels in smooth muscle cells isolated from rabbit portal vein. Also, PPZ2 generate cation currents and Ca (2+) influx of cultured rat neurons center.
Strikingly, both compounds induced BDNF -like neurite growth and neuroprotection, which was abolished by knockdown or inhibition TRPC3 / TRPC6 / TRPC7 in cultured neurons. Inhibitors of Ca (2+) signaling pathway, except calcineurin, promotion of neurite disruption caused by PPZ compound. PPZ2 increased activation of Ca (2 +) – dependent transcription factor , cAMP response element-binding protein.
These findings indicate that Ca (2+) signaling is mediated by activation of DAG-activated channel underlies TRPC neurotrophic the effect of the compound PPZ. Thus, piperazine- derived TRPC channel activator DAG-activated provide important insights for the future development of a new class of synthetic neurotrophic drug.
Relevance of Post-Stroke Circulating Levels of BDNF as a prognostic biomarker Stroke Outcomes.
Impact of rt-PA treatment. recombinant the form of tissue plasminogen activator (rt-PA) is the only curative treatment for ischemic stroke. More recently, the t-PA has been associated with metabolic brain – derived neurotrophic factor ( BDNF ), the main neurotrophin is involved in post-stroke neuroplasticity.
Thus, the purpose of our study was to investigate the effects of rt-PA treatment of post-stroke circulating BDNF level Human and in animals. Serum BDNF levels and t-PA activity / plasmin was measured at admission and up to 90 days in stroke patients who receive (n = 2 4 ) or not (n = 1 4 ) rt-PA perfusion. We investigated the relationship between serum BDNF with the same t-PA / plasmin activity, the results of neurological and cardiovascular score at admission.
Recombinant Human Neurotrophin-4 |
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7-01305 | CHI Scientific | 1mg | Ask for price |
Recombinant Human Neurotrophin-4 |
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AP60103 | SAB | 100ug | EUR 1554 |
Recombinant Human Neurotrophin-4 |
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cyt-626-10g | ProSpec Tany | 10µg | EUR 145 |
Recombinant Human Neurotrophin-4 |
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cyt-626-1mg | ProSpec Tany | 1mg | EUR 4680 |
Recombinant Human Neurotrophin-4 |
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cyt-626-2g | ProSpec Tany | 2µg | EUR 60 |
Neurotrophin-4, recombinant (Human) |
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033-30 | PHOENIX PEPTIDE | 10 μg | EUR 390.96 |
Neurotrophin-4 Human Recombinant |
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rAP-2701 | Angio Proteomie | Inquiry | Ask for price |
Recombinant Human Neurotrophin-4(NTF4) |
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AP72096 | SAB | 1mg | EUR 1978 |
Recombinant Human Neurotrophin-4 (NTF4), partial |
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CSB-EP016121HU1 | Cusabio | 1830 mg | Ask for price |
Recombinant Human NT-3/Neurotrophin-3 Protein |
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E40KMP1632 | EnoGene | 20ug | EUR 495 |
Genorise® Recombinant feline Neurotrophin 4 (NT-4) protein |
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GR186036 | Genorise Scientific | 5 mg | EUR 285 |
Recombinant Neurotrophin 4 (NT4) |
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RPU53898-100ug | Biomatik Corporation | 100ug | EUR 566.5 |
Recombinant Neurotrophin 4 (NT4) |
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RPU53898-1mg | Biomatik Corporation | 1mg | EUR 2511.6 |
Recombinant Neurotrophin 4 (NT4) |
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RPU53898-50ug | Biomatik Corporation | 50ug | EUR 455.4 |
Recombinant Neurotrophin 4 (NT4) |
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RPU43034-100ug | Biomatik Corporation | 100ug | EUR 552.2 |
Recombinant Neurotrophin 4 (NT4) |
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RPU43034-1mg | Biomatik Corporation | 1mg | EUR 2446.6 |
Recombinant Neurotrophin 4 (NT4) |
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RPU43034-50ug | Biomatik Corporation | 50ug | EUR 443.3 |
Recombinant Neurotrophin 4 (NT4) |
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RPU59108-100ug | Biomatik Corporation | 100ug | EUR 1044.4 |
Recombinant Neurotrophin 4 (NT4) |
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RPU59108-1mg | Biomatik Corporation | 1mg | EUR 4083.3 |
Recombinant Neurotrophin 4 (NT4) |
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RPU59108-50ug | Biomatik Corporation | 50ug | EUR 652.6 |
Recombinant Neurotrophin 4 (NT4) |
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RPU56286-100ug | Biomatik Corporation | 100ug | EUR 775.5 |
Recombinant Neurotrophin 4 (NT4) |
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RPU56286-1mg | Biomatik Corporation | 1mg | EUR 3057.6 |
Recombinant Neurotrophin 4 (NT4) |
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RPU56286-50ug | Biomatik Corporation | 50ug | EUR 470.4 |
Recombinant Neurotrophin 4 (NT4) |
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RPA107Hu01 | Cloud-Clone | 10ug | EUR 184 |
Recombinant Neurotrophin 4 (NT4) |
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4-RPA107Hu01 | Cloud-Clone |
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Description: Recombinant Human Neurotrophin 4 expressed in: E.coli |
Recombinant Neurotrophin 4 (NT4) |
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RPA107Mu01 | Cloud-Clone | 10ug | EUR 179 |
Recombinant Neurotrophin 4 (NT4) |
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4-RPA107Mu01 | Cloud-Clone |
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Description: Recombinant Mouse Neurotrophin 4 expressed in: E.coli |
Recombinant Neurotrophin 4 (NT4) |
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RPA107Ra01 | Cloud-Clone | 10ug | EUR 196 |
NT-3 Neurotrophin-3 Human Recombinant Protein |
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PROTP20783 | BosterBio | Regular: 10ug | EUR 380.4 |
Description: Neurotrophin-3 Human Recombinant produced in E.Coli is a non-glycosylated and non-covalently linked homodimer, containing 2x119 amino acid chains, having a total Mw of 27.2 kDa.;The NT-3 is purified by proprietary chromatographic techniques. |
Recombinant Human Neurotrophin-4 protein(NTF4) (Active) |
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AP73547 | SAB | 1mg | EUR 6829 |
Recombinant Human Neurotrophin-4 protein (NTF4) (Active) |
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CSB-AP002831HU | Cusabio | 8451 mg | Ask for price |
Recombinant Human Neurotrophin-3/NGF-2/NT-3 Protein |
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RP00496 | Abclonal | 10 μg | EUR 286 |
Recombinant Human Neurotrophin-3 |
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7-01294 | CHI Scientific | 2µg | Ask for price |
Recombinant Human Neurotrophin-3 |
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7-01295 | CHI Scientific | 10µg | Ask for price |
Recombinant Human Neurotrophin-3 |
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7-01296 | CHI Scientific | 1mg | Ask for price |
Recombinant Human Neurotrophin-3 |
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cyt-257-10g | ProSpec Tany | 10µg | EUR 145 |
Recombinant Human Neurotrophin-3 |
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cyt-257-1mg | ProSpec Tany | 1mg | EUR 4680 |
Recombinant Human Neurotrophin-3 |
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cyt-257-2g | ProSpec Tany | 2µg | EUR 60 |
Recombinant Human Neurotrophin-1 |
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cyt-869-10g | ProSpec Tany | 10µg | EUR 145 |
Recombinant Human Neurotrophin-1 |
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cyt-869-1mg | ProSpec Tany | 1mg | EUR 4680 |
Recombinant Human Neurotrophin-1 |
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cyt-869-2g | ProSpec Tany | 2µg | EUR 60 |
Neurotrophin-3, recombinant (Human) |
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033-29 | PHOENIX PEPTIDE | 10 μg | EUR 390.96 |
Human Neurotrophin-3 (Recombinant) |
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22060430-1 | Glycomatrix | 2 µg | EUR 146.42 |
Recombinant Human NT-3/Neurotrophin-3/NTF3 Protein, No Tag |
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E40KMH1479 | EnoGene | 20ug | EUR 495 |
Neurotrophin-3 Human Recombinant |
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rAP-2697 | Angio Proteomie | Inquiry | Ask for price |
Neurotrophin-1 Human Recombinant |
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rAP-2707 | Angio Proteomie | Inquiry | Ask for price |
Recombinant Human Neurotrophin-3/NT3 |
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AP74825 | SAB | 1mg | EUR 3209 |
Recombinant Human Neurotrophin-3/NT3 |
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C079-10ug | Novoprotein | 10ug | EUR 242.4 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 250mM NaCl, pH 7.2. |
Recombinant Human Neurotrophin-3/NT3 |
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C079-1mg | Novoprotein | 1mg | EUR 2739.6 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 250mM NaCl, pH 7.2. |
Recombinant Human Neurotrophin-3/NT3 |
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C079-500ug | Novoprotein | 500ug | EUR 1910.4 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 250mM NaCl, pH 7.2. |
Recombinant Human Neurotrophin-3/NT3 |
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C079-50ug | Novoprotein | 50ug | EUR 595.2 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 250mM NaCl, pH 7.2. |
Recombinant Human Neurotrophin-3 (NTF3) |
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CSB-EP016120HU | Cusabio | 7990 mg | Ask for price |
Recombinant Human Neurotrophin-3 (NTF3) |
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CSB-MP016120HU | Cusabio | 7843 mg | Ask for price |
Recombinant Human Neurotrophin-3 (NTF3) |
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CSB-BP016120HU | Cusabio | 7886 mg | Ask for price |
Recombinant Human Neurotrophin-3 (NTF3) |
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RPC27838-100ug | Biomatik Corporation | 100ug | EUR 1463 |
Recombinant Human Neurotrophin-3 (NTF3) |
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RPC27838-1mg | Biomatik Corporation | 1mg | EUR 6879.6 |
Recombinant Human Neurotrophin-3 (NTF3) |
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RPC27838-20ug | Biomatik Corporation | 20ug | EUR 550 |
Recombinant Human Neurotrophin-3 (NTF3) |
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RPC28701-100ug | Biomatik Corporation | 100ug | EUR 1170.4 |
Recombinant Human Neurotrophin-3 (NTF3) |
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RPC28701-1mg | Biomatik Corporation | 1mg | EUR 3252 |
Recombinant Human Neurotrophin-3 (NTF3) |
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RPC28701-20ug | Biomatik Corporation | 20ug | EUR 440 |
Recombinant Human Neurotrophin-3 (NTF3) |
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RPC28729-100ug | Biomatik Corporation | 100ug | EUR 528 |
Recombinant Human Neurotrophin-3 (NTF3) |
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RPC28729-1mg | Biomatik Corporation | 1mg | EUR 2412.5 |
Recombinant Human Neurotrophin-3 (NTF3) |
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RPC28729-20ug | Biomatik Corporation | 20ug | EUR 295.7 |
NT-4, Neurotrophin-4, human |
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RC218-15 | Bio Basic | 2ug | EUR 125.26 |
NT-3 Neurotrophin-3 Mouse Recombinant Protein |
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PROTP20181 | BosterBio | Regular: 10ug | EUR 380.4 |
Description: Neurotrophin-3 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 119 amino acids and having a molecular mass of 13.6kDa. ;The NT-3 is purified by proprietary chromatographic techniques. |
Genorise® recombinant Sheep Neurotrophin 4 |
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GR123022 | Genorise Scientific | 5 µg | EUR 285 |
Recombinant Human Precursor Neurotrophin-3 |
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7-01297 | CHI Scientific | 2µg | Ask for price |
Recombinant Human Precursor Neurotrophin-3 |
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7-01298 | CHI Scientific | 10µg | Ask for price |
Recombinant Human Precursor Neurotrophin-3 |
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7-01299 | CHI Scientific | 1mg | Ask for price |
Recombinant Human Neurotrophin-3 (NTF3) (Active) |
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CSB-AP003801HU | Cusabio | 8580 mg | Ask for price |
Genorise® Recombinant Equine Neurotrophin-4 protein |
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GR104319 | Genorise Scientific | 5 µg | EUR 285 |
NNT1 Neurotrophin-1 Human Recombinant Protein |
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PROTQ9UBD9-1 | BosterBio | Regular: 10ug | EUR 380.4 |
Description: Neurotrophin-1 Human Recombinant (28-225) produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 199 amino acids and having a molecular mass of 22kDa.;The NNT-1 is purified by proprietary chromatographic techniques. |
Genorise® recombinant Bovine Neurotrophin 4 protein |
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GR120051 | Genorise Scientific | 5 µg | EUR 285 |
Genorise® recombinant Canine Neurotrophin 4 protein |
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GR122076 | Genorise Scientific | 5 µg | EUR 285 |
Neurotrophin-3, recombinant (Human) - I-125 Labeled |
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T-033-29 | PHOENIX PEPTIDE | 10 μCi | EUR 1145.88 |
Recombinant Human Neurotrophin-3/NTF3 Protein (Active) |
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PKSH032803-10ug | Elabscience Biotech | 10ug | EUR 178 |
Description: Human |
Recombinant Human Neurotrophin-3/NTF3 Protein (Active) |
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PKSH032803-50ug | Elabscience Biotech | 50ug | EUR 523 |
Description: Human |
Recombinant Mouse Neurotrophin-3 |
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7-01300 | CHI Scientific | 2µg | Ask for price |
Recombinant Mouse Neurotrophin-3 |
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7-01301 | CHI Scientific | 10µg | Ask for price |
Recombinant Mouse Neurotrophin-3 |
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7-01302 | CHI Scientific | 1mg | Ask for price |
Recombinant Mouse Neurotrophin-3 |
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cyt-688-10g | ProSpec Tany | 10µg | EUR 145 |
Recombinant Mouse Neurotrophin-3 |
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cyt-688-1mg | ProSpec Tany | 1mg | EUR 4680 |
Recombinant Mouse Neurotrophin-3 |
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cyt-688-2g | ProSpec Tany | 2µg | EUR 60 |
Neurotrophin-3 Mouse Recombinant |
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rAP-2702 | Angio Proteomie | Inquiry | Ask for price |
Human NT-4(Neurotrophin-4) ELISA Kit |
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EH0246 | FN Test | 96T | EUR 628.92 |
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 56.25pg/ml |
Recombinant Human Neurotrophin-3 Polypeptide (a. a. 119) |
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DAG339 | Creative Diagnostics | 10ug | EUR 897.6 |
Recombinant Neurotrophin 3 (NT3) |
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RPU43032-100ug | Biomatik Corporation | 100ug | EUR 530.2 |
Recombinant Neurotrophin 3 (NT3) |
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RPU43032-1mg | Biomatik Corporation | 1mg | EUR 2347.8 |
Recombinant Neurotrophin 3 (NT3) |
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RPU43032-50ug | Biomatik Corporation | 50ug | EUR 425.7 |
Recombinant Neurotrophin 3 (NT3) |
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RPU43033-100ug | Biomatik Corporation | 100ug | EUR 530.2 |
Recombinant Neurotrophin 3 (NT3) |
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RPU43033-1mg | Biomatik Corporation | 1mg | EUR 2347.8 |
Recombinant Neurotrophin 3 (NT3) |
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RPU43033-50ug | Biomatik Corporation | 50ug | EUR 425.7 |
Recombinant Neurotrophin 3 (NT3) |
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RPU56113-100ug | Biomatik Corporation | 100ug | EUR 554.4 |
Recombinant Neurotrophin 3 (NT3) |
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RPU56113-1mg | Biomatik Corporation | 1mg | EUR 2184 |
Recombinant Neurotrophin 3 (NT3) |
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RPU56113-50ug | Biomatik Corporation | 50ug | EUR 336 |
Recombinant Neurotrophin 3 (NT3) |
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RPU56654-100ug | Biomatik Corporation | 100ug | EUR 470.4 |
Recombinant Neurotrophin 3 (NT3) |
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RPU56654-1mg | Biomatik Corporation | 1mg | EUR 2184 |
Recombinant Neurotrophin 3 (NT3) |
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RPU56654-50ug | Biomatik Corporation | 50ug | EUR 385 |
Recombinant Neurotrophin 3 (NT3) |
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RPU55489-100ug | Biomatik Corporation | 100ug | EUR 728.2 |
Recombinant Neurotrophin 3 (NT3) |
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RPU55489-1mg | Biomatik Corporation | 1mg | EUR 2870.4 |
Recombinant Neurotrophin 3 (NT3) |
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RPU55489-50ug | Biomatik Corporation | 50ug | EUR 441.6 |
Recombinant Neurotrophin 3 (NT3) |
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RPA106Hu01 | Cloud-Clone | 10ug | EUR 172 |
Recombinant Neurotrophin 3 (NT3) |
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4-RPA106Hu01 | Cloud-Clone |
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Description: Recombinant Human Neurotrophin 3 expressed in: E.coli |
Recombinant Neurotrophin 3 (NT3) |
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RPA106Hu02 | Cloud-Clone | 10ug | EUR 172 |
Recombinant Neurotrophin 3 (NT3) |
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4-RPA106Hu02 | Cloud-Clone |
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Description: Recombinant Human Neurotrophin 3 expressed in: E.coli |
Recombinant Neurotrophin 3 (NT3) |
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RPA106Mu01 | Cloud-Clone | 10ug | EUR 140 |
Recombinant Neurotrophin 3 (NT3) |
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RPA106Mu02 | Cloud-Clone | 10ug | EUR 140 |
Recombinant Neurotrophin 3 (NT3) |
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RPA106Ra01 | Cloud-Clone | 10ug | EUR 184 |
Recombinant Neurotrophin 3 (NT3) |
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4-RPA106Ra01 | Cloud-Clone |
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Description: Recombinant Rat Recombinant Neurotrophin 3 (NT3) expressed in: E.coli |
Recombinant Neurotrophin 3 (NT3) |
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RPA106Ra02 | Cloud-Clone | 10ug | EUR 140 |
Recombinant Neurotrophin 3 (NT3) |
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4-RPA106Ra02 | Cloud-Clone |
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Description: Recombinant Rat Neurotrophin 3 expressed in: E.coli |
Human Neurotrophin 4 (NT-4) CLIA Kit |
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abx197346-96tests | Abbexa | 96 tests | EUR 990 |
Neurotrophin-3 Recombinant Protein |
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91-065 | ProSci | 0.05 mg | EUR 821.4 |
Description: Neurotrophin-3 (NT-3) is a member of the NGF family of neurotrophic factors and is structurally related to beta -NGF, BDNF and NT-4. The NT3 cDNA encodes a 257 amino acid residue precursor protein with a signal peptide and a proprotein that are cleaved to yield the 119 amino acid residue mature NT3.The amino acid sequences of mature human, murine and rat NT-3 are identical. NT-3 selectively promotes the differentiation and survival of specific neuronal subpopulations in both the central as well as the peripheral nervous systems. |
Human Neurotrophin 4,NT-4 ELISA KIT |
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201-12-1293 | SunredBio | 96 tests | EUR 528 |
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
Human Neurotrophin 4(NT-4) Elisa Kit |
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EK713201 | AFG Bioscience LLC | 96 Wells | EUR 0.33 |
Human Neurotrophin 4(NT-4) Elisa Kit |
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EK711240 | AFG Bioscience LLC | 96 Wells | EUR 0.15 |
Human Neurotrophin 4,NT-4 ELISA KIT |
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EKC34810-48T | Biomatik Corporation | 48T | EUR 389.34 |
Human Neurotrophin 4,NT-4 ELISA KIT |
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EKC34810-5x96T | Biomatik Corporation | 5x96T | EUR 2641.95 |
Human Neurotrophin 4,NT-4 ELISA KIT |
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EKC34810-96T | Biomatik Corporation | 96T | EUR 556.2 |
Human Neurotrophin 4(NT-4)ELISA Kit |
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GA-E1309HM-48T | GenAsia Biotech | 48T | EUR 346.8 |
Human Neurotrophin 4(NT-4)ELISA Kit |
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GA-E1309HM-96T | GenAsia Biotech | 96T | EUR 559.2 |
Human Neurotrophin 4, NT-4 ELISA KIT |
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CSB-E04689h-24T | Cusabio | 1 plate of 24 wells | EUR 198 |
Description: Quantitativesandwich ELISA kit for measuring Human Neurotrophin 4, NT-4 in samples from serum, plasma, cell culture supernates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Human Neurotrophin 4, NT-4 ELISA KIT |
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1-CSB-E04689h | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Human Neurotrophin 4, NT-4 in samples from serum, plasma, cell culture supernates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Human Neurotrophin 4,NT-4 ELISA KIT |
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CN-03258H1 | ChemNorm | 96T | EUR 525.6 |
Human Neurotrophin 4,NT-4 ELISA KIT |
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CN-03258H2 | ChemNorm | 48T | EUR 346.8 |
In parallel, serum BDNF levels and t-PA activity / plasmin were assessed before and after (1, 4 and 2 4 h) induced an ischemic stroke in mice. Our study showed higher serum BDNF levels and better neurological outcomes in the rt-PA-treated compared to non-treated patients. However, serum BDNF level does not predict the outcome of a blow when the entire cohort of stroke patients were analyzed.