transient receptor potential canonical (TRPC) proteins form Ca (2 +) – permeable cation channel activated on stimulation of metabotropic receptors coupled to phospholipase C. Among the subfamily TRPC, TRPC3 and TRPC6 channel directly activated by diacylglycerol (DAG) plays an important role in < em> brain – derived neurotrophic factor ( BDNF ) signals, promoting the development of neuronal and survival , In various disease models, BDNF to restore neurological deficit, but its therapeutic potential is limited by poor pharmacokinetic profiles.

Explanation framework for designing small molecules, which Stirs BDNF -like activity through TRPC3 and TRPC6, establish a solid basis to overcome these limitations. We found, through the screening of the library, a group of piperazine- derived a compound that activates a DAG-activated TRPC3 / TRPC6 / TRPC7 channels. Compound 4 – (5-chloro-2-methylphenyl) piperazine-1-yl methanone (PPZ1) and 2 – [ 4 – (2 , 3-dimethylphenyl) piperazine-1-yl] -N- (2-ethoxyphenyl) acetamide (PPZ2) is activated, dose-dependent manner, recombinant TRPC3 / TRPC6 / TRPC7 channels, but no other TRPCs, The human embryonic kidney cells. PPZ2 activated TRPC6 as the original channels in smooth muscle cells isolated from rabbit portal vein. Also, PPZ2 generate cation currents and Ca (2+) influx of cultured rat neurons center.

Strikingly, both compounds induced BDNF -like neurite growth and neuroprotection, which was abolished by knockdown or inhibition TRPC3 / TRPC6 / TRPC7 in cultured neurons. Inhibitors of Ca (2+) signaling pathway, except calcineurin, promotion of neurite disruption caused by PPZ compound. PPZ2 increased activation of Ca (2 +) – dependent transcription factor , cAMP response element-binding protein.

These findings indicate that Ca (2+) signaling is mediated by activation of DAG-activated channel underlies TRPC neurotrophic the effect of the compound PPZ. Thus, piperazine- derived TRPC channel activator DAG-activated provide important insights for the future development of a new class of synthetic neurotrophic drug.

Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds.
Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds.

Relevance of Post-Stroke Circulating Levels of BDNF as a prognostic biomarker Stroke Outcomes.

Impact of rt-PA treatment. recombinant the form of tissue plasminogen activator (rt-PA) is the only curative treatment for ischemic stroke. More recently, the t-PA has been associated with metabolic brain – derived neurotrophic factor ( BDNF ), the main neurotrophin is involved in post-stroke neuroplasticity.

Thus, the purpose of our study was to investigate the effects of rt-PA treatment of post-stroke circulating BDNF level Human and in animals. Serum BDNF levels and t-PA activity / plasmin was measured at admission and up to 90 days in stroke patients who receive (n = 2 4 ) or not (n = 1 4 ) rt-PA perfusion. We investigated the relationship between serum BDNF with the same t-PA / plasmin activity, the results of neurological and cardiovascular score at admission.

Recombinant Human Neurotrophin-4

7-01305 1mg Ask for price

Recombinant Human Neurotrophin-4

AP60103 100ug
EUR 1554

Recombinant Human Neurotrophin-4

cyt-626-10g 10µg
EUR 145

Recombinant Human Neurotrophin-4

cyt-626-1mg 1mg
EUR 4680

Recombinant Human Neurotrophin-4

cyt-626-2g 2µg
EUR 60

Neurotrophin-4, recombinant (Human)

033-30 10 μg
EUR 390.96

Neurotrophin-4 Human Recombinant

rAP-2701 Inquiry Ask for price

Recombinant Human Neurotrophin-4(NTF4)

AP72096 1mg
EUR 1978

Recombinant Human Neurotrophin-4 (NTF4), partial

CSB-EP016121HU1 1830 mg Ask for price

Recombinant Human NT-3/Neurotrophin-3 Protein

E40KMP1632 20ug
EUR 495

Genorise® Recombinant feline Neurotrophin 4 (NT-4) protein

GR186036 5 mg
EUR 285

Recombinant Neurotrophin 4 (NT4)

RPU53898-100ug 100ug
EUR 566.5

Recombinant Neurotrophin 4 (NT4)

RPU53898-1mg 1mg
EUR 2511.6

Recombinant Neurotrophin 4 (NT4)

RPU53898-50ug 50ug
EUR 455.4

Recombinant Neurotrophin 4 (NT4)

RPU43034-100ug 100ug
EUR 552.2

Recombinant Neurotrophin 4 (NT4)

RPU43034-1mg 1mg
EUR 2446.6

Recombinant Neurotrophin 4 (NT4)

RPU43034-50ug 50ug
EUR 443.3

Recombinant Neurotrophin 4 (NT4)

RPU59108-100ug 100ug
EUR 1044.4

Recombinant Neurotrophin 4 (NT4)

RPU59108-1mg 1mg
EUR 4083.3

Recombinant Neurotrophin 4 (NT4)

RPU59108-50ug 50ug
EUR 652.6

Recombinant Neurotrophin 4 (NT4)

RPU56286-100ug 100ug
EUR 775.5

Recombinant Neurotrophin 4 (NT4)

RPU56286-1mg 1mg
EUR 3057.6

Recombinant Neurotrophin 4 (NT4)

RPU56286-50ug 50ug
EUR 470.4

Recombinant Neurotrophin 4 (NT4)

RPA107Hu01 10ug
EUR 184

Recombinant Neurotrophin 4 (NT4)

4-RPA107Hu01
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Description: Recombinant Human Neurotrophin 4 expressed in: E.coli

Recombinant Neurotrophin 4 (NT4)

RPA107Mu01 10ug
EUR 179

Recombinant Neurotrophin 4 (NT4)

4-RPA107Mu01
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Description: Recombinant Mouse Neurotrophin 4 expressed in: E.coli

Recombinant Neurotrophin 4 (NT4)

RPA107Ra01 10ug
EUR 196

NT-3 Neurotrophin-3 Human Recombinant Protein

PROTP20783 Regular: 10ug
EUR 380.4
Description: Neurotrophin-3 Human Recombinant produced in E.Coli is a non-glycosylated and non-covalently linked homodimer, containing 2x119 amino acid chains, having a total Mw of 27.2 kDa.;The NT-3 is purified by proprietary chromatographic techniques.

Recombinant Human Neurotrophin-4 protein(NTF4) (Active)

AP73547 1mg
EUR 6829

Recombinant Human Neurotrophin-4 protein (NTF4) (Active)

CSB-AP002831HU 8451 mg Ask for price

Recombinant Human Neurotrophin-3/NGF-2/NT-3 Protein

RP00496 10 μg
EUR 286

Recombinant Human Neurotrophin-3

7-01294 2µg Ask for price

Recombinant Human Neurotrophin-3

7-01295 10µg Ask for price

Recombinant Human Neurotrophin-3

7-01296 1mg Ask for price

Recombinant Human Neurotrophin-3

cyt-257-10g 10µg
EUR 145

Recombinant Human Neurotrophin-3

cyt-257-1mg 1mg
EUR 4680

Recombinant Human Neurotrophin-3

cyt-257-2g 2µg
EUR 60

Recombinant Human Neurotrophin-1

cyt-869-10g 10µg
EUR 145

Recombinant Human Neurotrophin-1

cyt-869-1mg 1mg
EUR 4680

Recombinant Human Neurotrophin-1

cyt-869-2g 2µg
EUR 60

Neurotrophin-3, recombinant (Human)

033-29 10 μg
EUR 390.96

Human Neurotrophin-3 (Recombinant)

22060430-1 2 µg
EUR 146.42

Recombinant Human NT-3/Neurotrophin-3/NTF3 Protein, No Tag

E40KMH1479 20ug
EUR 495

Neurotrophin-3 Human Recombinant

rAP-2697 Inquiry Ask for price

Neurotrophin-1 Human Recombinant

rAP-2707 Inquiry Ask for price

Recombinant Human Neurotrophin-3/NT3

AP74825 1mg
EUR 3209

Recombinant Human Neurotrophin-3/NT3

C079-10ug 10ug
EUR 242.4
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 250mM NaCl, pH 7.2.

Recombinant Human Neurotrophin-3/NT3

C079-1mg 1mg
EUR 2739.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 250mM NaCl, pH 7.2.

Recombinant Human Neurotrophin-3/NT3

C079-500ug 500ug
EUR 1910.4
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 250mM NaCl, pH 7.2.

Recombinant Human Neurotrophin-3/NT3

C079-50ug 50ug
EUR 595.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 250mM NaCl, pH 7.2.

Recombinant Human Neurotrophin-3 (NTF3)

CSB-EP016120HU 7990 mg Ask for price

Recombinant Human Neurotrophin-3 (NTF3)

CSB-MP016120HU 7843 mg Ask for price

Recombinant Human Neurotrophin-3 (NTF3)

CSB-BP016120HU 7886 mg Ask for price

Recombinant Human Neurotrophin-3 (NTF3)

RPC27838-100ug 100ug
EUR 1463

Recombinant Human Neurotrophin-3 (NTF3)

RPC27838-1mg 1mg
EUR 6879.6

Recombinant Human Neurotrophin-3 (NTF3)

RPC27838-20ug 20ug
EUR 550

Recombinant Human Neurotrophin-3 (NTF3)

RPC28701-100ug 100ug
EUR 1170.4

Recombinant Human Neurotrophin-3 (NTF3)

RPC28701-1mg 1mg
EUR 3252

Recombinant Human Neurotrophin-3 (NTF3)

RPC28701-20ug 20ug
EUR 440

Recombinant Human Neurotrophin-3 (NTF3)

RPC28729-100ug 100ug
EUR 528

Recombinant Human Neurotrophin-3 (NTF3)

RPC28729-1mg 1mg
EUR 2412.5

Recombinant Human Neurotrophin-3 (NTF3)

RPC28729-20ug 20ug
EUR 295.7

NT-4, Neurotrophin-4, human

RC218-15 2ug
EUR 125.26

NT-3 Neurotrophin-3 Mouse Recombinant Protein

PROTP20181 Regular: 10ug
EUR 380.4
Description: Neurotrophin-3 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 119 amino acids and having a molecular mass of 13.6kDa. ;The NT-3 is purified by proprietary chromatographic techniques.

Genorise® recombinant Sheep Neurotrophin 4

GR123022 5 µg
EUR 285

Recombinant Human Precursor Neurotrophin-3

7-01297 2µg Ask for price

Recombinant Human Precursor Neurotrophin-3

7-01298 10µg Ask for price

Recombinant Human Precursor Neurotrophin-3

7-01299 1mg Ask for price

Recombinant Human Neurotrophin-3 (NTF3) (Active)

CSB-AP003801HU 8580 mg Ask for price

Genorise® Recombinant Equine Neurotrophin-4 protein

GR104319 5 µg
EUR 285

NNT1 Neurotrophin-1 Human Recombinant Protein

PROTQ9UBD9-1 Regular: 10ug
EUR 380.4
Description: Neurotrophin-1 Human Recombinant (28-225) produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 199 amino acids and having a molecular mass of 22kDa.;The NNT-1 is purified by proprietary chromatographic techniques.

Genorise® recombinant Bovine Neurotrophin 4 protein

GR120051 5 µg
EUR 285

Genorise® recombinant Canine Neurotrophin 4 protein

GR122076 5 µg
EUR 285

Neurotrophin-3, recombinant (Human) - I-125 Labeled

T-033-29 10 μCi
EUR 1145.88

Recombinant Human Neurotrophin-3/NTF3 Protein (Active)

PKSH032803-10ug 10ug
EUR 178
Description: Human

Recombinant Human Neurotrophin-3/NTF3 Protein (Active)

PKSH032803-50ug 50ug
EUR 523
Description: Human

Recombinant Mouse Neurotrophin-3

7-01300 2µg Ask for price

Recombinant Mouse Neurotrophin-3

7-01301 10µg Ask for price

Recombinant Mouse Neurotrophin-3

7-01302 1mg Ask for price

Recombinant Mouse Neurotrophin-3

cyt-688-10g 10µg
EUR 145

Recombinant Mouse Neurotrophin-3

cyt-688-1mg 1mg
EUR 4680

Recombinant Mouse Neurotrophin-3

cyt-688-2g 2µg
EUR 60

Neurotrophin-3 Mouse Recombinant

rAP-2702 Inquiry Ask for price

Human NT-4(Neurotrophin-4) ELISA Kit

EH0246 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 56.25pg/ml

Recombinant Human Neurotrophin-3 Polypeptide (a. a. 119)

DAG339 10ug
EUR 897.6

Recombinant Neurotrophin 3 (NT3)

RPU43032-100ug 100ug
EUR 530.2

Recombinant Neurotrophin 3 (NT3)

RPU43032-1mg 1mg
EUR 2347.8

Recombinant Neurotrophin 3 (NT3)

RPU43032-50ug 50ug
EUR 425.7

Recombinant Neurotrophin 3 (NT3)

RPU43033-100ug 100ug
EUR 530.2

Recombinant Neurotrophin 3 (NT3)

RPU43033-1mg 1mg
EUR 2347.8

Recombinant Neurotrophin 3 (NT3)

RPU43033-50ug 50ug
EUR 425.7

Recombinant Neurotrophin 3 (NT3)

RPU56113-100ug 100ug
EUR 554.4

Recombinant Neurotrophin 3 (NT3)

RPU56113-1mg 1mg
EUR 2184

Recombinant Neurotrophin 3 (NT3)

RPU56113-50ug 50ug
EUR 336

Recombinant Neurotrophin 3 (NT3)

RPU56654-100ug 100ug
EUR 470.4

Recombinant Neurotrophin 3 (NT3)

RPU56654-1mg 1mg
EUR 2184

Recombinant Neurotrophin 3 (NT3)

RPU56654-50ug 50ug
EUR 385

Recombinant Neurotrophin 3 (NT3)

RPU55489-100ug 100ug
EUR 728.2

Recombinant Neurotrophin 3 (NT3)

RPU55489-1mg 1mg
EUR 2870.4

Recombinant Neurotrophin 3 (NT3)

RPU55489-50ug 50ug
EUR 441.6

Recombinant Neurotrophin 3 (NT3)

RPA106Hu01 10ug
EUR 172

Recombinant Neurotrophin 3 (NT3)

4-RPA106Hu01
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Description: Recombinant Human Neurotrophin 3 expressed in: E.coli

Recombinant Neurotrophin 3 (NT3)

RPA106Hu02 10ug
EUR 172

Recombinant Neurotrophin 3 (NT3)

4-RPA106Hu02
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Description: Recombinant Human Neurotrophin 3 expressed in: E.coli

Recombinant Neurotrophin 3 (NT3)

RPA106Mu01 10ug
EUR 140

Recombinant Neurotrophin 3 (NT3)

RPA106Mu02 10ug
EUR 140

Recombinant Neurotrophin 3 (NT3)

RPA106Ra01 10ug
EUR 184

Recombinant Neurotrophin 3 (NT3)

4-RPA106Ra01
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  • 5 mg
Description: Recombinant Rat Recombinant Neurotrophin 3 (NT3) expressed in: E.coli

Recombinant Neurotrophin 3 (NT3)

RPA106Ra02 10ug
EUR 140

Recombinant Neurotrophin 3 (NT3)

4-RPA106Ra02
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  • 100 ug
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Description: Recombinant Rat Neurotrophin 3 expressed in: E.coli

Human Neurotrophin 4 (NT-4) CLIA Kit

abx197346-96tests 96 tests
EUR 990

Neurotrophin-3 Recombinant Protein

91-065 0.05 mg
EUR 821.4
Description: Neurotrophin-3 (NT-3) is a member of the NGF family of neurotrophic factors and is structurally related to beta -NGF, BDNF and NT-4. The NT3 cDNA encodes a 257 amino acid residue precursor protein with a signal peptide and a proprotein that are cleaved to yield the 119 amino acid residue mature NT3.The amino acid sequences of mature human, murine and rat NT-3 are identical. NT-3 selectively promotes the differentiation and survival of specific neuronal subpopulations in both the central as well as the peripheral nervous systems.

Human Neurotrophin 4,NT-4 ELISA KIT

201-12-1293 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Neurotrophin 4(NT-4) Elisa Kit

EK713201 96 Wells
EUR 0.33

Human Neurotrophin 4(NT-4) Elisa Kit

EK711240 96 Wells
EUR 0.15

Human Neurotrophin 4,NT-4 ELISA KIT

EKC34810-48T 48T
EUR 389.34

Human Neurotrophin 4,NT-4 ELISA KIT

EKC34810-5x96T 5x96T
EUR 2641.95

Human Neurotrophin 4,NT-4 ELISA KIT

EKC34810-96T 96T
EUR 556.2

Human Neurotrophin 4(NT-4)ELISA Kit

GA-E1309HM-48T 48T
EUR 346.8

Human Neurotrophin 4(NT-4)ELISA Kit

GA-E1309HM-96T 96T
EUR 559.2

Human Neurotrophin 4, NT-4 ELISA KIT

CSB-E04689h-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human Neurotrophin 4, NT-4 in samples from serum, plasma, cell culture supernates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Neurotrophin 4, NT-4 ELISA KIT

1-CSB-E04689h
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Description: Quantitativesandwich ELISA kit for measuring Human Neurotrophin 4, NT-4 in samples from serum, plasma, cell culture supernates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Neurotrophin 4,NT-4 ELISA KIT

CN-03258H1 96T
EUR 525.6

Human Neurotrophin 4,NT-4 ELISA KIT

CN-03258H2 48T
EUR 346.8

In parallel, serum BDNF levels and t-PA activity / plasmin were assessed before and after (1, 4 and 2 4 h) induced an ischemic stroke in mice. Our study showed higher serum BDNF levels and better neurological outcomes in the rt-PA-treated compared to non-treated patients. However, serum BDNF level does not predict the outcome of a blow when the entire cohort of stroke patients were analyzed.