transient receptor potential canonical (TRPC) proteins form Ca (2 +) – permeable cation channel activated on stimulation of metabotropic receptors coupled to phospholipase C. Among the subfamily TRPC, TRPC3 and TRPC6 channel directly activated by diacylglycerol (DAG) plays an important role in < em> brain – derived neurotrophic factor ( BDNF ) signals, promoting the development of neuronal and survival , In various disease models, BDNF to restore neurological deficit, but its therapeutic potential is limited by poor pharmacokinetic profiles.

Explanation framework for designing small molecules, which Stirs BDNF -like activity through TRPC3 and TRPC6, establish a solid basis to overcome these limitations. We found, through the screening of the library, a group of piperazine- derived a compound that activates a DAG-activated TRPC3 / TRPC6 / TRPC7 channels. Compound 4 – (5-chloro-2-methylphenyl) piperazine-1-yl methanone (PPZ1) and 2 – [ 4 – (2 , 3-dimethylphenyl) piperazine-1-yl] -N- (2-ethoxyphenyl) acetamide (PPZ2) is activated, dose-dependent manner, recombinant TRPC3 / TRPC6 / TRPC7 channels, but no other TRPCs, The human embryonic kidney cells. PPZ2 activated TRPC6 as the original channels in smooth muscle cells isolated from rabbit portal vein. Also, PPZ2 generate cation currents and Ca (2+) influx of cultured rat neurons center.

Strikingly, both compounds induced BDNF -like neurite growth and neuroprotection, which was abolished by knockdown or inhibition TRPC3 / TRPC6 / TRPC7 in cultured neurons. Inhibitors of Ca (2+) signaling pathway, except calcineurin, promotion of neurite disruption caused by PPZ compound. PPZ2 increased activation of Ca (2 +) – dependent transcription factor , cAMP response element-binding protein.

These findings indicate that Ca (2+) signaling is mediated by activation of DAG-activated channel underlies TRPC neurotrophic the effect of the compound PPZ. Thus, piperazine- derived TRPC channel activator DAG-activated provide important insights for the future development of a new class of synthetic neurotrophic drug.

Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds.
Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds.

Relevance of Post-Stroke Circulating Levels of BDNF as a prognostic biomarker Stroke Outcomes.

Impact of rt-PA treatment. recombinant the form of tissue plasminogen activator (rt-PA) is the only curative treatment for ischemic stroke. More recently, the t-PA has been associated with metabolic brain – derived neurotrophic factor ( BDNF ), the main neurotrophin is involved in post-stroke neuroplasticity.

Thus, the purpose of our study was to investigate the effects of rt-PA treatment of post-stroke circulating BDNF level Human and in animals. Serum BDNF levels and t-PA activity / plasmin was measured at admission and up to 90 days in stroke patients who receive (n = 2 4 ) or not (n = 1 4 ) rt-PA perfusion. We investigated the relationship between serum BDNF with the same t-PA / plasmin activity, the results of neurological and cardiovascular score at admission.

NT-4 (Neurotrophin-4) GMP, CF

PR15132CF 5 ug
EUR 610

IL-4 Interleukin 4 Human Recombinant Protein, Yeast

PROTP05112-4 Regular: 10ug
EUR 317
Description: Interleukin-4 Human Recombinant produced in yeast is a single, glycosylated polypeptide chain containing 129 amino acids.;The IL-4 is purified by proprietary chromatographic techniques.

Human Neurotrophin 4,NT-4 ELISA KIT

201-12-1293 96 tests
EUR 440
  • This Neurotrophin 4 ELISA kit is validated to work with samples from whole blood, serum, plasma and cell culture supernatant.
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Neurotrophin 4, NT-4 ELISA KIT

CSB-E04689h-24T 1 plate of 24 wells
EUR 165
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Human Neurotrophin 4, NT-4 in samples from serum, plasma, cell culture supernates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Neurotrophin 4, NT-4 ELISA KIT

1-CSB-E04689h
  • EUR 574.00
  • EUR 4013.00
  • EUR 2138.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Human Neurotrophin 4, NT-4 in samples from serum, plasma, cell culture supernates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Neurotrophin 4 (NT-4) CLIA Kit

abx197346-96tests 96 tests
EUR 825
  • Shipped within 5-12 working days.

Human NT-4(Neurotrophin-4) ELISA Kit

EH0246 96T
EUR 524.1
  • Detection range: 93.75-6000 pg/ml
  • Uniprot ID: P34130
  • Alias: NT-4/NT-5/NTF4/NTF5/GLC10/GLC1O/neurotrophic factor 4/neurotrophic factor 5/neurotrophin 4/neurotrophin 5(neurotrophin 4/5)/neurotrophin-4/neurotrophin-5/NT4//NT-4/5/NTF5NT5
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 56.25pg/ml

Human Neurotrophin 4,NT-4 ELISA KIT

CN-03258H1 96T
EUR 438

Human Neurotrophin 4,NT-4 ELISA KIT

CN-03258H2 48T
EUR 289

Human Neurotrophin 4(NT-4)ELISA Kit

GA-E1309HM-48T 48T
EUR 289

Human Neurotrophin 4(NT-4)ELISA Kit

GA-E1309HM-96T 96T
EUR 466

Human Neurotrophin 4(NT-4)ELISA Kit

QY-E01633 96T
EUR 361

Mouse Neurotrophin 4, NT-4 ELISA KIT

CSB-E04690m-24T 1 plate of 24 wells
EUR 165
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Mouse Neurotrophin 4, NT-4 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse Neurotrophin 4, NT-4 ELISA KIT

1-CSB-E04690m
  • EUR 678.00
  • EUR 4644.00
  • EUR 2467.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Mouse Neurotrophin 4, NT-4 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Rat Neurotrophin 4, NT-4 ELISA KIT

CSB-E04691r-24T 1 plate of 24 wells
EUR 165
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Rat Neurotrophin 4, NT-4 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Rat Neurotrophin 4, NT-4 ELISA KIT

1-CSB-E04691r
  • EUR 678.00
  • EUR 4644.00
  • EUR 2467.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Rat Neurotrophin 4, NT-4 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Neurotrophin 4 (NT-4) CLIA Kit

abx197347-96tests 96 tests
EUR 825
  • Shipped within 5-12 working days.

Rat Neurotrophin 4 (NT-4) CLIA Kit

abx197348-96tests 96 tests
EUR 825
  • Shipped within 5-12 working days.

Rabbit neurotrophin 4,NT-4 ELISA Kit

CN-00681R1 96T
EUR 447

Rabbit neurotrophin 4,NT-4 ELISA Kit

CN-00681R2 48T
EUR 296

Rat Neurotrophin 4,NT-4 ELISA KIT

CN-01592R1 96T
EUR 464

Rat Neurotrophin 4,NT-4 ELISA KIT

CN-01592R2 48T
EUR 313

Mouse Neurotrophin 4,NT-4 ELISA KIT

CN-02428M1 96T
EUR 441

Mouse Neurotrophin 4,NT-4 ELISA KIT

CN-02428M2 48T
EUR 291

Mouse NT-4(Neurotrophin 4) ELISA Kit

EM1243 96T
EUR 524.1
  • Detection range: 15.625-1000 pg/ml
  • Uniprot ID: Q80VU4
  • Alias: NT-4//NT-5/NTF4/NTF5/GLC10/GLC1O/neurotrophic factor 4/neurotrophic factor 5/neurotrophin 4/neurotrophin 5(neurotrophin 4/5)/neurotrophin-4/neurotrophin-5/NT4//NT-4/5/NTF5NT5
Description: Method of detection: Double Antibody, Sandwich ELISA ;Reacts with: Mus ;Sensitivity: 9.375pg/ml

Rat NT-4(Neurotrophin 4) ELISA Kit

ER1201 96T
EUR 524.1
  • Detection range: 31.25-2000 pg/ml
  • Uniprot ID: P34131
  • Alias: NT-4/NT-5/NTF4/NTF5/GLC10/GLC1O/neurotrophic factor 4/neurotrophic factor 5/neurotrophin 4/neurotrophin 5(neurotrophin 4/5)/neurotrophin-4/Neurotrophin-5/neurotrophin-5/Neutrophic factor 4/N
  • Show more
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 18.75pg/ml

Rat Neurotrophin 4(NT-4)ELISA Kit

GA-E0552RT-48T 48T
EUR 317

Rat Neurotrophin 4(NT-4)ELISA Kit

GA-E0552RT-96T 96T
EUR 496

Mouse Neurotrophin 4(NT-4)ELISA Kit

GA-E0098MS-48T 48T
EUR 336

Mouse Neurotrophin 4(NT-4)ELISA Kit

GA-E0098MS-96T 96T
EUR 534

Rabbit neurotrophin 4,NT-4 ELISA Kit

GA-E0149RB-48T 48T
EUR 326

Rabbit neurotrophin 4,NT-4 ELISA Kit

GA-E0149RB-96T 96T
EUR 524

Rat Neurotrophin 4(NT-4)ELISA Kit

QY-E11100 96T
EUR 361

Mouse Neurotrophin 4(NT-4)ELISA Kit

QY-E21081 96T
EUR 361

Rabbit neurotrophin 4,NT-4 ELISA Kit

QY-E30150 96T
EUR 374

CLIA kit for Human NT-4 (Neurotrophin 4)

E-CL-H1172 1 plate of 96 wells
EUR 584
  • Gentaur's NT-4 CLIA kit utilizes the Sandwich- CLIA principle. The micro CLIA plate provided in this kit has been pre-coated with an antibody specific to Human NT-4 . Standards or samples are added to the micro CLIA plate wells and combined with the
  • Show more
Description: A sandwich CLIA kit for quantitative measurement of Human NT-4 (Neurotrophin 4) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human NT-4 (Neurotrophin 4)

E-EL-H1897 1 plate of 96 wells
EUR 534
  • Gentaur's NT-4 ELISA kit utilizes the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Human NT-4. Standards or samples are added to the micro ELISA plate wells and combined with th
  • Show more
Description: A sandwich ELISA kit for quantitative measurement of Human NT-4 (Neurotrophin 4) in samples from Serum, Plasma, Cell supernatant

Recombinant Human 4-1BB Receptor Protein

PROTQ07011-4 20ug
EUR 317
Description: 4-1BB Receptor, a member of the TNF superfamily of receptors, is mainly expressed on the surface of a variety of T cells, but also found in B cells, monocytes, and various transformed cell lines. 4-1BB Receptor binds to 4-1BBL to provide a co-stimulatory signal for T lymphocytes. Signaling by 4-1BB Receptor has been implicated in the antigen-presentation process and generation of cytotoxic T cells. The human 4-1BB Receptor gene codes for a 255 amino acid type I transmembrane protein containing a 17 amino acid N-terminal signal sequence, a 169 amino acid extracellular domain, a 27 amino acid transmembrane domain and a 42 amino acid cytoplasmic domain. Recombinant human soluble 4-1BB Receptor is a 167 amino acid polypeptide (17.7 kDa), which contains the cysteine rich TNFR-like extracellular domain of 4-1BB Receptor.

Recombinant Human PF-4 (CXCL4) Protein

PROTP02776-4 20ug
EUR 317
Description: PF-4 is a CXC chemokine that is expressed in megakaryocytes and stored in the α-granules of platelets. PF-4 is chemotactic towards neutrophils and monocytes and has been shown to inhibit angiogenesis. Recombinant human PF-4 is a 7.8 kDa protein containing 70 amino acid residues, including the four highly conserved residues present in CXC chemokines.

Feline IL-4 Recombinant Protein

R00230-4 5ug/vial
EUR 259
Description: IL-4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of CD4+ T-cells into Th2 cells. It is a key regulator in humoral and adaptive immunity. Feline IL-4 Recombinant Protein is purified interleukin-4 produced in yeast.

CLIA kit for Mouse NT-4 (Neurotrophin 4)

E-CL-M0512 1 plate of 96 wells
EUR 584
  • Gentaur's NT-4 CLIA kit utilizes the Sandwich- CLIA principle. The micro CLIA plate provided in this kit has been pre-coated with an antibody specific to Mouse NT-4 . Standards or samples are added to the micro CLIA plate wells and combined with the
  • Show more
Description: A sandwich CLIA kit for quantitative measurement of Mouse NT-4 (Neurotrophin 4) in samples from Serum, Plasma, Cell supernatant

CLIA kit for Rat NT-4 (Neurotrophin 4)

E-CL-R0476 1 plate of 96 wells
EUR 584
  • Gentaur's NT-4 CLIA kit utilizes the Sandwich- CLIA principle. The micro CLIA plate provided in this kit has been pre-coated with an antibody specific to Rat NT-4 . Standards or samples are added to the micro CLIA plate wells and combined with the sp
  • Show more
Description: A sandwich CLIA kit for quantitative measurement of Rat NT-4 (Neurotrophin 4) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Mouse NT-4 (Neurotrophin 4)

E-EL-M0824 1 plate of 96 wells
EUR 534
  • Gentaur's NT-4 ELISA kit utilizes the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Mouse NT-4. Standards or samples are added to the micro ELISA plate wells and combined with th
  • Show more
Description: A sandwich ELISA kit for quantitative measurement of Mouse NT-4 (Neurotrophin 4) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Rat NT-4 (Neurotrophin 4)

E-EL-R0659 1 plate of 96 wells
EUR 534
  • Gentaur's NT-4 ELISA kit utilizes the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Rat NT-4. Standards or samples are added to the micro ELISA plate wells and combined with the
  • Show more
Description: A sandwich ELISA kit for quantitative measurement of Rat NT-4 (Neurotrophin 4) in samples from Serum, Plasma, Cell supernatant

Recombinant Human Neurotrophin-4

7-01303 2µg Ask for price

Recombinant Human Neurotrophin-4

7-01304 10µg Ask for price

Recombinant Human Neurotrophin-4

7-01305 1mg Ask for price

NT-4 ELISA Kit| Rat Neurotrophin 4 ELISA Kit

EF017923 96 Tests
EUR 689

NT-4 ELISA Kit| Mouse Neurotrophin 4 ELISA Kit

EF013791 96 Tests
EUR 689

Human Neurotrophin-4 (NT-4) ELISA Kit, 96 tests, Quantitative

9695 1 Kit
EUR 773

Human FibrOut 4, for brain, neural

4-21552 1 ml Ask for price

Human FibrOut 4, for brain, neural

4-21553 5 x 1 ml Ask for price

Individual Reaction Mix 4

G065-4 200 reactions
EUR 167

NT-4, human recombinant

4309-10
EUR 256

NT-4, human recombinant

4309-1000
EUR 5106

NT-4, human recombinant

4309-50
EUR 697

pLenti-CLDN1 shRNA-4 Plasmid

PVTBAV04867-4 2 ug
EUR 356

Recombinant Neurotrophin 4 (NT4)

4-RPA107Hu01
  • EUR 512.16
  • EUR 240.00
  • EUR 1645.60
  • EUR 615.20
  • EUR 1130.40
  • EUR 406.00
  • EUR 3964.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: P34130
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 17.7kDa
  • Isoelectric Point: 9.1
Description: Recombinant Human Neurotrophin 4 expressed in: E.coli

Recombinant Neurotrophin 4 (NT4)

4-RPA107Mu01
  • EUR 501.41
  • EUR 237.00
  • EUR 1605.28
  • EUR 601.76
  • EUR 1103.52
  • EUR 398.00
  • EUR 3863.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: Q80VU4
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 17.7kDa
  • Isoelectric Point: 9.3
Description: Recombinant Mouse Neurotrophin 4 expressed in: E.coli

DIGITAL SHAKER FOR 4 MICROPLATES, 120V

6780-4 1/pk
EUR 798
Description: Lab Equipment; Shakers & Mixers

Mouse FibrOut 4, for brain, neural

4-20507 1 ml Ask for price

Mouse FibrOut 4, for brain, neural

4-20508 5 x 1 ml Ask for price

Rat FibrOut 4, for brain, neural

4-20533 1 ml Ask for price

Rat FibrOut 4, for brain, neural

4-20534 5 x 1 ml Ask for price

NT-4, Human

HY-P7272 50ug
EUR 762

NT-4 (human)

GT15001 100 ug
EUR 526

Bone Dissociation System 4 (Osteoblasts), Adult Mouse

4-20214 ea Ask for price

Liver Dissociation System 4 (Hepatocytes, rat), Rat

4-20304 ea Ask for price

Pituitary Dissociation System 4 (Pituitary), Adult mouse

4-20404 ea Ask for price

Thymus Dissociation System 4 (Epithelial), Adult rat

4-20444 ea Ask for price

Recombinant Human NT-4 Protein

PROTP34130-1 10ug
EUR 317
Description: NT-4 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-3. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-4 is expressed in the prostate, thymus, placenta and skeletal muscle. NT-4 can signal through the LNGFR and trkB receptors and promotes the survival of peripheral sensory sympathetic neurons. Recombinant human NT-4 is a noncovalently linked homodimer, of two 14.0 kDa polypeptide monomers (260 total amino acid residues).

ExoStd? Lyophilized Exosome Standard (30 µg, Human Plasma, 4 vials)

M1040-4
EUR 909

ExoStd? Lyophilized Exosome Standard (100 µg, Human Plasma, 4 vials)

M1041-4
EUR 1137

ExoStd? Lyophilized Exosome Standard (30 µg, Human Serum, 4 vials)

M1042-4
EUR 909

ExoStd? Lyophilized Exosome Standard (100 µg, Human Serum, 4 vials)

M1043-4
EUR 1132

ExoStd? Lyophilized Exosome Standard (30 µg, Human Urine, 4 vials)

M1044-4
EUR 909

ExoStd? Lyophilized Exosome Standard (100 µg, Human Urine, 4 vials)

M1045-4
EUR 1137

ExoStd? Lyophilized Exosome Standard (30 µg, Human Saliva, 4 vials)

M1046-4
EUR 914

ExoStd? Lyophilized Exosome Standard (100 µg, Human Saliva, 4 vials)

M1047-4
EUR 1137

rHu MIP-4

AK8218-0002 2µg Ask for price

rHu MIP-4

AK8218-0010 10µg Ask for price

rHu MIP-4

AK8218-0100 100µg Ask for price

rHu MIP-4

AK8218-1000 1mg Ask for price

rHu IL-4

AK8329-0005 5µg Ask for price

rHu IL-4

AK8329-0020 20µg Ask for price

rHu IL-4

AK8329-0100 100µg Ask for price

rHu IL-4

AK8329-1000 1mg Ask for price

rHu MCP-4

AK8332-0005 5µg Ask for price

rHu MCP-4

AK8332-0020 20µg Ask for price

rHu MCP-4

AK8332-0100 100µg Ask for price

rHu MCP-4

AK8332-1000 1mg Ask for price

rHu FGF-4

AK9698-0005 5µg Ask for price

rHu FGF-4

AK9698-0025 25µg Ask for price

rHu FGF-4

AK9698-0100 100µg Ask for price

rHu FGF-4

AK9698-1000 1mg Ask for price

DIGITAL SHAKER FOR 4 MICROPLATES, 230V-EU PLUG

6781-4 1/pk
EUR 798
Description: Lab Equipment; Shakers & Mixers

DIGITAL SHAKER FOR 4 MICROPLATES, 230V-UK PLUG

6782-4 1/pk
EUR 798
Description: Lab Equipment; Shakers & Mixers

Cartilage Dissociation System 4 (Chondrocytes), Mouse and Rat

4-20234 ea Ask for price

In parallel, serum BDNF levels and t-PA activity / plasmin were assessed before and after (1, 4 and 2 4 h) induced an ischemic stroke in mice. Our study showed higher serum BDNF levels and better neurological outcomes in the rt-PA-treated compared to non-treated patients. However, serum BDNF level does not predict the outcome of a blow when the entire cohort of stroke patients were analyzed.