transient receptor potential canonical (TRPC) proteins form Ca (2 +) – permeable cation channel activated on stimulation of metabotropic receptors coupled to phospholipase C. Among the subfamily TRPC, TRPC3 and TRPC6 channel directly activated by diacylglycerol (DAG) plays an important role in < em> brain – derived neurotrophic factor ( BDNF ) signals, promoting the development of neuronal and survival , In various disease models, BDNF to restore neurological deficit, but its therapeutic potential is limited by poor pharmacokinetic profiles.

Explanation framework for designing small molecules, which Stirs BDNF -like activity through TRPC3 and TRPC6, establish a solid basis to overcome these limitations. We found, through the screening of the library, a group of piperazine- derived a compound that activates a DAG-activated TRPC3 / TRPC6 / TRPC7 channels. Compound 4 – (5-chloro-2-methylphenyl) piperazine-1-yl methanone (PPZ1) and 2 – [ 4 – (2 , 3-dimethylphenyl) piperazine-1-yl] -N- (2-ethoxyphenyl) acetamide (PPZ2) is activated, dose-dependent manner, recombinant TRPC3 / TRPC6 / TRPC7 channels, but no other TRPCs, The human embryonic kidney cells. PPZ2 activated TRPC6 as the original channels in smooth muscle cells isolated from rabbit portal vein. Also, PPZ2 generate cation currents and Ca (2+) influx of cultured rat neurons center.

Strikingly, both compounds induced BDNF -like neurite growth and neuroprotection, which was abolished by knockdown or inhibition TRPC3 / TRPC6 / TRPC7 in cultured neurons. Inhibitors of Ca (2+) signaling pathway, except calcineurin, promotion of neurite disruption caused by PPZ compound. PPZ2 increased activation of Ca (2 +) – dependent transcription factor , cAMP response element-binding protein.

These findings indicate that Ca (2+) signaling is mediated by activation of DAG-activated channel underlies TRPC neurotrophic the effect of the compound PPZ. Thus, piperazine- derived TRPC channel activator DAG-activated provide important insights for the future development of a new class of synthetic neurotrophic drug.

Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds.
Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds.

Relevance of Post-Stroke Circulating Levels of BDNF as a prognostic biomarker Stroke Outcomes.

Impact of rt-PA treatment. recombinant the form of tissue plasminogen activator (rt-PA) is the only curative treatment for ischemic stroke. More recently, the t-PA has been associated with metabolic brain – derived neurotrophic factor ( BDNF ), the main neurotrophin is involved in post-stroke neuroplasticity.

Thus, the purpose of our study was to investigate the effects of rt-PA treatment of post-stroke circulating BDNF level Human and in animals. Serum BDNF levels and t-PA activity / plasmin was measured at admission and up to 90 days in stroke patients who receive (n = 2 4 ) or not (n = 1 4 ) rt-PA perfusion. We investigated the relationship between serum BDNF with the same t-PA / plasmin activity, the results of neurological and cardiovascular score at admission.

Human Neurotrophin 4, NT-4 ELISA KIT

CSB-E04689h-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human Neurotrophin 4, NT-4 in samples from serum, plasma, cell culture supernates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Neurotrophin 4, NT-4 ELISA KIT

1-CSB-E04689h
  • EUR 688.80
  • EUR 4815.60
  • EUR 2565.60
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Neurotrophin 4, NT-4 in samples from serum, plasma, cell culture supernates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Neurotrophin 4,NT-4 ELISA KIT

CN-03258H1 96T
EUR 525.6

Human Neurotrophin 4,NT-4 ELISA KIT

CN-03258H2 48T
EUR 346.8

Human Neurotrophin 4 (NT-4) CLIA Kit

abx197346-96tests 96 tests
EUR 990

Human Neurotrophin 4,NT-4 ELISA KIT

201-12-1293 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human NT-4(Neurotrophin-4) ELISA Kit

EH0246 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 56.25pg/ml

Human Neurotrophin 4(NT-4)ELISA Kit

GA-E1309HM-48T 48T
EUR 346.8

Human Neurotrophin 4(NT-4)ELISA Kit

GA-E1309HM-96T 96T
EUR 559.2

Human Neurotrophin 4(NT-4)ELISA Kit

QY-E01633 96T
EUR 433.2

Human Neurotrophin 4,NT-4 ELISA KIT

YLA1767HU-48T 48T
EUR 435

Human Neurotrophin 4,NT-4 ELISA KIT

YLA1767HU-96T 96T
EUR 562.5

Rabbit neurotrophin 4,NT-4 ELISA Kit

CN-00681R1 96T
EUR 536.4

Rabbit neurotrophin 4,NT-4 ELISA Kit

CN-00681R2 48T
EUR 355.2

Rat Neurotrophin 4,NT-4 ELISA KIT

CN-01592R1 96T
EUR 556.8

Rat Neurotrophin 4,NT-4 ELISA KIT

CN-01592R2 48T
EUR 375.6

Mouse Neurotrophin 4, NT-4 ELISA KIT

CSB-E04690m-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Mouse Neurotrophin 4, NT-4 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse Neurotrophin 4, NT-4 ELISA KIT

1-CSB-E04690m
  • EUR 813.60
  • EUR 5572.80
  • EUR 2960.40
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Mouse Neurotrophin 4, NT-4 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Rat Neurotrophin 4, NT-4 ELISA KIT

CSB-E04691r-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Rat Neurotrophin 4, NT-4 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Rat Neurotrophin 4, NT-4 ELISA KIT

1-CSB-E04691r
  • EUR 813.60
  • EUR 5572.80
  • EUR 2960.40
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Rat Neurotrophin 4, NT-4 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Neurotrophin 4,NT-4 ELISA KIT

CN-02428M1 96T
EUR 529.2

Mouse Neurotrophin 4,NT-4 ELISA KIT

CN-02428M2 48T
EUR 349.2

Mouse NT-4(Neurotrophin 4) ELISA Kit

EM1243 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA ;Reacts with: Mus ;Sensitivity: 9.375pg/ml

Rabbit neurotrophin 4,NT-4 ELISA Kit

GA-E0149RB-48T 48T
EUR 391.2

Rabbit neurotrophin 4,NT-4 ELISA Kit

GA-E0149RB-96T 96T
EUR 628.8

Mouse Neurotrophin 4(NT-4)ELISA Kit

GA-E0098MS-48T 48T
EUR 403.2

Mouse Neurotrophin 4(NT-4)ELISA Kit

GA-E0098MS-96T 96T
EUR 640.8

Rat NT-4(Neurotrophin 4) ELISA Kit

ER1201 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 18.75pg/ml

Mouse Neurotrophin 4 (NT-4) CLIA Kit

abx197347-96tests 96 tests
EUR 990

Rat Neurotrophin 4 (NT-4) CLIA Kit

abx197348-96tests 96 tests
EUR 990

Rat Neurotrophin 4(NT-4)ELISA Kit

GA-E0552RT-48T 48T
EUR 380.4

Rat Neurotrophin 4(NT-4)ELISA Kit

GA-E0552RT-96T 96T
EUR 595.2

Rat Neurotrophin 4(NT-4)ELISA Kit

QY-E11100 96T
EUR 433.2

Mouse Neurotrophin 4(NT-4)ELISA Kit

QY-E21081 96T
EUR 433.2

Rabbit neurotrophin 4,NT-4 ELISA Kit

QY-E30150 96T
EUR 448.8

Mouse Neurotrophin 4,NT-4 ELISA KIT

YLA0637MO-48T 48T
EUR 465

Mouse Neurotrophin 4,NT-4 ELISA KIT

YLA0637MO-96T 96T
EUR 600

Rat Neurotrophin 4,NT-4 ELISA KIT

YLA1017RA-48T 48T
EUR 465

Rat Neurotrophin 4,NT-4 ELISA KIT

YLA1017RA-96T 96T
EUR 600

ELISA kit for Human NT-4 (Neurotrophin 4)

E-EL-H1897 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Human NT-4 (Neurotrophin 4) in samples from Serum, Plasma, Cell supernatant

CLIA kit for Human NT-4 (Neurotrophin 4)

E-CL-H1172 1 plate of 96 wells
EUR 700.8
Description: A sandwich CLIA kit for quantitative measurement of Human NT-4 (Neurotrophin 4) in samples from Serum, Plasma, Cell supernatant

Recombinant Human 4-1BB Receptor Protein

PROTQ07011-4 20ug
EUR 380.4
Description: 4-1BB Receptor, a member of the TNF superfamily of receptors, is mainly expressed on the surface of a variety of T cells, but also found in B cells, monocytes, and various transformed cell lines. 4-1BB Receptor binds to 4-1BBL to provide a co-stimulatory signal for T lymphocytes. Signaling by 4-1BB Receptor has been implicated in the antigen-presentation process and generation of cytotoxic T cells. The human 4-1BB Receptor gene codes for a 255 amino acid type I transmembrane protein containing a 17 amino acid N-terminal signal sequence, a 169 amino acid extracellular domain, a 27 amino acid transmembrane domain and a 42 amino acid cytoplasmic domain. Recombinant human soluble 4-1BB Receptor is a 167 amino acid polypeptide (17.7 kDa), which contains the cysteine rich TNFR-like extracellular domain of 4-1BB Receptor.

Recombinant Human PF-4 (CXCL4) Protein

PROTP02776-4 20ug
EUR 380.4
Description: PF-4 is a CXC chemokine that is expressed in megakaryocytes and stored in the α-granules of platelets. PF-4 is chemotactic towards neutrophils and monocytes and has been shown to inhibit angiogenesis. Recombinant human PF-4 is a 7.8 kDa protein containing 70 amino acid residues, including the four highly conserved residues present in CXC chemokines.

Genorise® Recombinant feline Neurotrophin 4 (NT-4) protein

GR186036 5 mg
EUR 342

Feline IL-4 Recombinant Protein

R00230-4 5ug/vial
EUR 310.8
Description: IL-4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of CD4+ T-cells into Th2 cells. It is a key regulator in humoral and adaptive immunity. Feline IL-4 Recombinant Protein is purified interleukin-4 produced in yeast.

ELISA kit for Mouse NT-4 (Neurotrophin 4)

E-EL-M0824 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Mouse NT-4 (Neurotrophin 4) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Rat NT-4 (Neurotrophin 4)

E-EL-R0659 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Rat NT-4 (Neurotrophin 4) in samples from Serum, Plasma, Cell supernatant

CLIA kit for Mouse NT-4 (Neurotrophin 4)

E-CL-M0512 1 plate of 96 wells
EUR 700.8
Description: A sandwich CLIA kit for quantitative measurement of Mouse NT-4 (Neurotrophin 4) in samples from Serum, Plasma, Cell supernatant

CLIA kit for Rat NT-4 (Neurotrophin 4)

E-CL-R0476 1 plate of 96 wells
EUR 700.8
Description: A sandwich CLIA kit for quantitative measurement of Rat NT-4 (Neurotrophin 4) in samples from Serum, Plasma, Cell supernatant

Recombinant Neurotrophin 4 (NT4)

4-RPA107Hu01
  • EUR 614.59
  • EUR 288.00
  • EUR 1974.72
  • EUR 738.24
  • EUR 1356.48
  • EUR 487.20
  • EUR 4756.80
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Neurotrophin 4 expressed in: E.coli

Recombinant Neurotrophin 4 (NT4)

4-RPA107Mu01
  • EUR 601.69
  • EUR 284.40
  • EUR 1926.34
  • EUR 722.11
  • EUR 1324.22
  • EUR 477.60
  • EUR 4635.84
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Neurotrophin 4 expressed in: E.coli

Human FibrOut 4, for brain, neural

4-21552 1 ml Ask for price

Human FibrOut 4, for brain, neural

4-21553 5 x 1 ml Ask for price

Human Neurotrophin-4 (NT-4) ELISA Kit, 96 tests, Quantitative

9695 1 Kit
EUR 927.6

NT-4 ELISA Kit| Rat Neurotrophin 4 ELISA Kit

EF017923 96 Tests
EUR 826.8

NT-4 ELISA Kit| Mouse Neurotrophin 4 ELISA Kit

EF013791 96 Tests
EUR 826.8

Nori® Equine Neurotrophin-4 (NT-4) ELISA Kit

GR106821 96-well
EUR 553.2

Nori® Rabbit Neurotrophin 4 (NT-4) ELISA Kit

GR144249 96-well
EUR 553.2

Nori® Feline Neurotrophin 4 (NT-4) ELISA Kit

GR188268 96-well
EUR 553.2

Nori® Bovine Neurotrophin-4 (NT-4) ELISA Kit

GR112286 96-well
EUR 553.2

Nori® Porcine Neurotrophin 4 (NT-4) ELISA Kit

GR113325 96-well
EUR 553.2

Nori® Canine Neurotrophin 4 (NT-4) ELISA Kit

GR115325 96-well
EUR 553.2

Nori® Sheep Neurotrophin-4 (NT-4) ELISA Kit

GR116296 96-well
EUR 553.2

Individual Reaction Mix 4

G065-4 200 reactions
EUR 200.4

Recombinant Human Neurotrophin-4

7-01303 2µg Ask for price

Recombinant Human Neurotrophin-4

7-01304 10µg Ask for price

Recombinant Human Neurotrophin-4

7-01305 1mg Ask for price

pLenti-CLDN1 shRNA-4 Plasmid

PVTBAV04867-4 2 ug
EUR 427.2

Digital Shaker For 4 Microplates

6782-4 EACH
EUR 1110.36

Human Neurotrophin-4

90226-A 2 µg
EUR 130
Description: Recombinant NT-4 is a disulfide-linked homodimer protein consisting of two 131 amino acid residues, and migrates as an approximately 29 kDa protein under non-reducing and as 14 kDa under reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Neurotrophin-4 mature chain was expressed in E. coli.

Human Neurotrophin-4

90226-B 10 µg
EUR 205
Description: Recombinant NT-4 is a disulfide-linked homodimer protein consisting of two 131 amino acid residues, and migrates as an approximately 29 kDa protein under non-reducing and as 14 kDa under reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Neurotrophin-4 mature chain was expressed in E. coli.

Recombinant Human Interleukin-4 (rHu IL-4)

AK9839-0010 10ug
EUR 780

Recombinant Human Interleukin-4 (rHu IL-4)

AK9839-0030 30ug
EUR 1356

Recombinant Human Interleukin-4 (rHu IL-4)

AK9839-0100 100ug
EUR 2040

NT-4, human recombinant

4309-10 each
EUR 307.2

NT-4, human recombinant

4309-1000 each
EUR 6127.2

NT-4, human recombinant

4309-50 each
EUR 836.4

DIGITAL SHAKER FOR 4 MICROPLATES, 120V

6780-4 1/pk
EUR 957.6
Description: Lab Equipment; Shakers & Mixers

Mouse FibrOut 4, for brain, neural

4-20507 1 ml Ask for price

Mouse FibrOut 4, for brain, neural

4-20508 5 x 1 ml Ask for price

Rat FibrOut 4, for brain, neural

4-20533 1 ml Ask for price

Rat FibrOut 4, for brain, neural

4-20534 5 x 1 ml Ask for price

ICP-MS Multi-Element Solution 4

CLMS-4 125ML
EUR 221.16

Bone Dissociation System 4 (Osteoblasts), Adult Mouse

4-20214 ea Ask for price

Liver Dissociation System 4 (Hepatocytes, rat), Rat

4-20304 ea Ask for price

Pituitary Dissociation System 4 (Pituitary), Adult mouse

4-20404 ea Ask for price

Thymus Dissociation System 4 (Epithelial), Adult rat

4-20444 ea Ask for price

NT-4, Human

HY-P7272 50ug
EUR 914.4

NT-4 (human)

GT15001 100 ug
EUR 631.2

ExoStd? Lyophilized Exosome Standard (30 µg, Human Plasma, 4 vials)

M1040-4 each
EUR 1090.8

ExoStd? Lyophilized Exosome Standard (100 µg, Human Plasma, 4 vials)

M1041-4 each
EUR 1364.4

ExoStd? Lyophilized Exosome Standard (30 µg, Human Serum, 4 vials)

M1042-4 each
EUR 1090.8

ExoStd? Lyophilized Exosome Standard (100 µg, Human Serum, 4 vials)

M1043-4 each
EUR 1358.4

ExoStd? Lyophilized Exosome Standard (30 µg, Human Urine, 4 vials)

M1044-4 each
EUR 1090.8

ExoStd? Lyophilized Exosome Standard (100 µg, Human Urine, 4 vials)

M1045-4 each
EUR 1364.4

ExoStd? Lyophilized Exosome Standard (30 µg, Human Saliva, 4 vials)

M1046-4 each
EUR 1096.8

ExoStd? Lyophilized Exosome Standard (100 µg, Human Saliva, 4 vials)

M1047-4 each
EUR 1364.4

rHu MIP-4

AK8218-0002 2µg Ask for price

rHu MIP-4

AK8218-0010 10µg Ask for price

rHu MIP-4

AK8218-0100 100µg Ask for price

rHu MIP-4

AK8218-1000 1mg Ask for price

rHu IL-4

AK8329-0005 5µg Ask for price

rHu IL-4

AK8329-0020 20µg Ask for price

rHu IL-4

AK8329-0100 100µg Ask for price

rHu IL-4

AK8329-1000 1mg Ask for price

rHu MCP-4

AK8332-0005 5µg Ask for price

rHu MCP-4

AK8332-0020 20µg Ask for price

rHu MCP-4

AK8332-0100 100µg Ask for price

rHu MCP-4

AK8332-1000 1mg Ask for price

rHu FGF-4

AK9698-0005 5µg Ask for price

rHu FGF-4

AK9698-0025 25µg Ask for price

rHu FGF-4

AK9698-0100 100µg Ask for price

rHu FGF-4

AK9698-1000 1mg Ask for price

DIGITAL SHAKER FOR 4 MICROPLATES, 230V-EU PLUG

6781-4 1/pk
EUR 957.6
Description: Lab Equipment; Shakers & Mixers

Cartilage Dissociation System 4 (Chondrocytes), Mouse and Rat

4-20234 ea Ask for price

Mammary Dissociation System 4 (Epithelial, Swiss 3T3), Mouse

4-20324 ea Ask for price

Pancreas Dissociation System 4 (Islets), Mouse and Rat

4-20374 ea Ask for price

Skin Dissociation System 4 (Keratinocytes), Mouse and Rat

4-20434 ea Ask for price

Pesticide Mix 4 Containing 15 Compounds in Acetonitrile

SPXPR-4 1ML
EUR 175.56

Human Neurotrophin-4 (NTF4)

1-CSB-RP099294h
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Neurotrophin-4(NTF4) expressed in E.coli

Recombinant Human NT-4 Protein

PROTP34130-1 10ug
EUR 380.4
Description: NT-4 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-3. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-4 is expressed in the prostate, thymus, placenta and skeletal muscle. NT-4 can signal through the LNGFR and trkB receptors and promotes the survival of peripheral sensory sympathetic neurons. Recombinant human NT-4 is a noncovalently linked homodimer, of two 14.0 kDa polypeptide monomers (260 total amino acid residues).

anti-Neurotrophin 4

YF-PA24273 50 ul
EUR 400.8
Description: Mouse polyclonal to Neurotrophin 4

anti-Neurotrophin 4

YF-PA13491 50 ul
EUR 435.6
Description: Mouse polyclonal to Neurotrophin 4

anti-Neurotrophin 4

YF-PA13492 100 ul
EUR 483.6
Description: Rabbit polyclonal to Neurotrophin 4

anti-Neurotrophin 4

YF-PA13493 100 ug
EUR 483.6
Description: Rabbit polyclonal to Neurotrophin 4

In parallel, serum BDNF levels and t-PA activity / plasmin were assessed before and after (1, 4 and 2 4 h) induced an ischemic stroke in mice. Our study showed higher serum BDNF levels and better neurological outcomes in the rt-PA-treated compared to non-treated patients. However, serum BDNF level does not predict the outcome of a blow when the entire cohort of stroke patients were analyzed.