transient receptor potential canonical (TRPC) proteins form Ca (2 +) – permeable cation channel activated on stimulation of metabotropic receptors coupled to phospholipase C. Among the subfamily TRPC, TRPC3 and TRPC6 channel directly activated by diacylglycerol (DAG) plays an important role in < em> brain – derived neurotrophic factor ( BDNF ) signals, promoting the development of neuronal and survival , In various disease models, BDNF to restore neurological deficit, but its therapeutic potential is limited by poor pharmacokinetic profiles.

Explanation framework for designing small molecules, which Stirs BDNF -like activity through TRPC3 and TRPC6, establish a solid basis to overcome these limitations. We found, through the screening of the library, a group of piperazine- derived a compound that activates a DAG-activated TRPC3 / TRPC6 / TRPC7 channels. Compound 4 – (5-chloro-2-methylphenyl) piperazine-1-yl methanone (PPZ1) and 2 – [ 4 – (2 , 3-dimethylphenyl) piperazine-1-yl] -N- (2-ethoxyphenyl) acetamide (PPZ2) is activated, dose-dependent manner, recombinant TRPC3 / TRPC6 / TRPC7 channels, but no other TRPCs, The human embryonic kidney cells. PPZ2 activated TRPC6 as the original channels in smooth muscle cells isolated from rabbit portal vein. Also, PPZ2 generate cation currents and Ca (2+) influx of cultured rat neurons center.

Strikingly, both compounds induced BDNF -like neurite growth and neuroprotection, which was abolished by knockdown or inhibition TRPC3 / TRPC6 / TRPC7 in cultured neurons. Inhibitors of Ca (2+) signaling pathway, except calcineurin, promotion of neurite disruption caused by PPZ compound. PPZ2 increased activation of Ca (2 +) – dependent transcription factor , cAMP response element-binding protein.

These findings indicate that Ca (2+) signaling is mediated by activation of DAG-activated channel underlies TRPC neurotrophic the effect of the compound PPZ. Thus, piperazine- derived TRPC channel activator DAG-activated provide important insights for the future development of a new class of synthetic neurotrophic drug.

Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds.
Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds.

Relevance of Post-Stroke Circulating Levels of BDNF as a prognostic biomarker Stroke Outcomes.

Impact of rt-PA treatment. recombinant the form of tissue plasminogen activator (rt-PA) is the only curative treatment for ischemic stroke. More recently, the t-PA has been associated with metabolic brain – derived neurotrophic factor ( BDNF ), the main neurotrophin is involved in post-stroke neuroplasticity.

Thus, the purpose of our study was to investigate the effects of rt-PA treatment of post-stroke circulating BDNF level Human and in animals. Serum BDNF levels and t-PA activity / plasmin was measured at admission and up to 90 days in stroke patients who receive (n = 2 4 ) or not (n = 1 4 ) rt-PA perfusion. We investigated the relationship between serum BDNF with the same t-PA / plasmin activity, the results of neurological and cardiovascular score at admission.

Recombinant Human Neurotrophin-4

7-01305 1mg Ask for price

Genorise® Recombinant feline Neurotrophin 4 (NT-4) protein

GR186036 5 mg
EUR 285

Recombinant Neurotrophin 4 (NT4)

4-RPA107Hu01
  • EUR 614.59
  • EUR 288.00
  • EUR 1974.72
  • EUR 738.24
  • EUR 1356.48
  • EUR 487.20
  • EUR 4756.80
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Neurotrophin 4 expressed in: E.coli

Recombinant Neurotrophin 4 (NT4)

4-RPA107Mu01
  • EUR 601.69
  • EUR 284.40
  • EUR 1926.34
  • EUR 722.11
  • EUR 1324.22
  • EUR 477.60
  • EUR 4635.84
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Neurotrophin 4 expressed in: E.coli

Recombinant Neurotrophin 4 (NT4)

RPU43034-100ug 100ug
EUR 552.2

Recombinant Neurotrophin 4 (NT4)

RPU43034-1mg 1mg
EUR 2446.6

Recombinant Neurotrophin 4 (NT4)

RPU43034-50ug 50ug
EUR 443.3

Recombinant Neurotrophin 4 (NT4)

RPU53898-100ug 100ug
EUR 566.5

Recombinant Neurotrophin 4 (NT4)

RPU53898-1mg 1mg
EUR 2511.6

Recombinant Neurotrophin 4 (NT4)

RPU53898-50ug 50ug
EUR 455.4

Recombinant Neurotrophin 4 (NT4)

RPU59108-100ug 100ug
EUR 1044.4

Recombinant Neurotrophin 4 (NT4)

RPU59108-1mg 1mg
EUR 4083.3

Recombinant Neurotrophin 4 (NT4)

RPU59108-50ug 50ug
EUR 652.6

Recombinant Neurotrophin 4 (NT4)

RPU56286-100ug 100ug
EUR 775.5

Recombinant Neurotrophin 4 (NT4)

RPU56286-1mg 1mg
EUR 3057.6

Recombinant Neurotrophin 4 (NT4)

RPU56286-50ug 50ug
EUR 470.4

NT-4, Neurotrophin-4, human

RC218-15 2ug
EUR 125.26

Recombinant Human NT-3/Neurotrophin-3 Protein

RP00496 10 μg
EUR 265.2

Recombinant Human NT-3/Neurotrophin-3 Protein

E40KMP1632 20ug
EUR 495

NT-3 Neurotrophin-3 Human Recombinant Protein

PROTP20783 Regular: 10ug
EUR 380.4
Description: Neurotrophin-3 Human Recombinant produced in E.Coli is a non-glycosylated and non-covalently linked homodimer, containing 2x119 amino acid chains, having a total Mw of 27.2 kDa.;The NT-3 is purified by proprietary chromatographic techniques.

Genorise® recombinant Sheep Neurotrophin 4

GR123022 5 µg
EUR 285

Human NT-4(Neurotrophin-4) ELISA Kit

EH0246 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 56.25pg/ml

Recombinant Human Neurotrophin-3

7-01294 2µg Ask for price

Recombinant Human Neurotrophin-3

7-01295 10µg Ask for price

Recombinant Human Neurotrophin-3

7-01296 1mg Ask for price

Human Neurotrophin 4 (NT-4) CLIA Kit

abx197346-96tests 96 tests
EUR 990

Human Neurotrophin 4,NT-4 ELISA KIT

201-12-1293 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Neurotrophin 4,NT-4 ELISA KIT

CN-03258H1 96T
EUR 525.6

Human Neurotrophin 4,NT-4 ELISA KIT

CN-03258H2 48T
EUR 346.8

Human Neurotrophin 4, NT-4 ELISA KIT

CSB-E04689h-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human Neurotrophin 4, NT-4 in samples from serum, plasma, cell culture supernates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Neurotrophin 4, NT-4 ELISA KIT

1-CSB-E04689h
  • EUR 688.80
  • EUR 4815.60
  • EUR 2565.60
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Neurotrophin 4, NT-4 in samples from serum, plasma, cell culture supernates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Neurotrophin 4(NT-4)ELISA Kit

GA-E1309HM-48T 48T
EUR 346.8

Human Neurotrophin 4(NT-4)ELISA Kit

GA-E1309HM-96T 96T
EUR 559.2

Human Neurotrophin 4(NT-4)ELISA Kit

QY-E01633 96T
EUR 433.2

Human Neurotrophin 4,NT-4 ELISA KIT

YLA1767HU-48T 48T
EUR 435

Human Neurotrophin 4,NT-4 ELISA KIT

YLA1767HU-96T 96T
EUR 562.5

Human Neurotrophin 4,NT-4 ELISA KIT

EKC34810-48T 48T
EUR 389.34

Human Neurotrophin 4,NT-4 ELISA KIT

EKC34810-5x96T 5x96T
EUR 2641.95

Human Neurotrophin 4,NT-4 ELISA KIT

EKC34810-96T 96T
EUR 556.2

Human Neurotrophin 4,NT-4 ELISA Kit

SL1266Hu 96 Tests
EUR 468

Human Neurotrophin 4 (NT-4) ELISA Kit

RK00316 96T
EUR 280

Human NT-4 (Neurotrophin 4) ELISA Kit

EKE61097-5x96T 5x96T
EUR 3124.08

Human NT-4 (Neurotrophin 4) ELISA Kit

EKE61097-96T 96T
EUR 657.7

Human Neurotrophin-3 (Recombinant)

22060430-1 2 µg
EUR 146.42

Recombinant Human NT-3/Neurotrophin-3/NTF3 Protein, No Tag

E40KMH1479 20ug
EUR 495

NT-4 (Neurotrophin-4) GMP, CF

PR15132CF 5 ug
EUR 732

NT-3 Neurotrophin-3 Mouse Recombinant Protein

PROTP20181 Regular: 10ug
EUR 380.4
Description: Neurotrophin-3 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 119 amino acids and having a molecular mass of 13.6kDa. ;The NT-3 is purified by proprietary chromatographic techniques.

Recombinant Human Neurotrophin-3/NT3

C079-10ug 10ug
EUR 242.4
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 250mM NaCl, pH 7.2.

Recombinant Human Neurotrophin-3/NT3

C079-1mg 1mg
EUR 2739.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 250mM NaCl, pH 7.2.

Recombinant Human Neurotrophin-3/NT3

C079-500ug 500ug
EUR 1910.4
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 250mM NaCl, pH 7.2.

Recombinant Human Neurotrophin-3/NT3

C079-50ug 50ug
EUR 595.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 250mM NaCl, pH 7.2.

Genorise® Recombinant Equine Neurotrophin-4 protein

GR104319 5 µg
EUR 285

Recombinant Human Neurotrophin-3 (NTF3)

RPC28729-100ug 100ug
EUR 528

Recombinant Human Neurotrophin-3 (NTF3)

RPC28729-1mg 1mg
EUR 2412.5

Recombinant Human Neurotrophin-3 (NTF3)

RPC28729-20ug 20ug
EUR 295.7

Recombinant Human Neurotrophin-3 (NTF3)

RPC27838-100ug 100ug
EUR 1463

Recombinant Human Neurotrophin-3 (NTF3)

RPC27838-1mg 1mg
EUR 6879.6

Recombinant Human Neurotrophin-3 (NTF3)

RPC27838-20ug 20ug
EUR 550

Recombinant Human Neurotrophin-3 (NTF3)

RPC28701-100ug 100ug
EUR 1170.4

Recombinant Human Neurotrophin-3 (NTF3)

RPC28701-1mg 1mg
EUR 3252

Recombinant Human Neurotrophin-3 (NTF3)

RPC28701-20ug 20ug
EUR 440

CLIA kit for Human NT-4 (Neurotrophin 4)

E-CL-H1172 1 plate of 96 wells
EUR 700.8
Description: A sandwich CLIA kit for quantitative measurement of Human NT-4 (Neurotrophin 4) in samples from Serum, Plasma, Cell supernatant

Genorise® recombinant Bovine Neurotrophin 4 protein

GR120051 5 µg
EUR 285

Genorise® recombinant Canine Neurotrophin 4 protein

GR122076 5 µg
EUR 285

ELISA kit for Human NT-4 (Neurotrophin 4)

E-EL-H1897 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Human NT-4 (Neurotrophin 4) in samples from Serum, Plasma, Cell supernatant

Recombinant Human Precursor Neurotrophin-3

7-01297 2µg Ask for price

Recombinant Human Precursor Neurotrophin-3

7-01298 10µg Ask for price

Recombinant Human Precursor Neurotrophin-3

7-01299 1mg Ask for price

Human Neurotrophin-4

90226-A 2 µg
EUR 130
Description: Recombinant NT-4 is a disulfide-linked homodimer protein consisting of two 131 amino acid residues, and migrates as an approximately 29 kDa protein under non-reducing and as 14 kDa under reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Neurotrophin-4 mature chain was expressed in E. coli.

Human Neurotrophin-4

90226-B 10 µg
EUR 205
Description: Recombinant NT-4 is a disulfide-linked homodimer protein consisting of two 131 amino acid residues, and migrates as an approximately 29 kDa protein under non-reducing and as 14 kDa under reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Neurotrophin-4 mature chain was expressed in E. coli.

Rat Neurotrophin 4 (NT-4) CLIA Kit

abx197348-96tests 96 tests
EUR 990

Rat Neurotrophin 4,NT-4 ELISA KIT

CN-01592R1 96T
EUR 556.8

Rat Neurotrophin 4,NT-4 ELISA KIT

CN-01592R2 48T
EUR 375.6

Rat Neurotrophin 4, NT-4 ELISA KIT

CSB-E04691r-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Rat Neurotrophin 4, NT-4 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Rat Neurotrophin 4, NT-4 ELISA KIT

1-CSB-E04691r
  • EUR 813.60
  • EUR 5572.80
  • EUR 2960.40
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Rat Neurotrophin 4, NT-4 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Rat NT-4(Neurotrophin 4) ELISA Kit

ER1201 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 18.75pg/ml

Rat Neurotrophin 4(NT-4)ELISA Kit

GA-E0552RT-48T 48T
EUR 380.4

Rat Neurotrophin 4(NT-4)ELISA Kit

GA-E0552RT-96T 96T
EUR 595.2

Rat Neurotrophin 4(NT-4)ELISA Kit

QY-E11100 96T
EUR 433.2

Rat Neurotrophin 4,NT-4 ELISA KIT

YLA1017RA-48T 48T
EUR 465

Rat Neurotrophin 4,NT-4 ELISA KIT

YLA1017RA-96T 96T
EUR 600

Rat NT-4 (Neurotrophin 4) ELISA Kit

EKE62213-5x96T 5x96T
EUR 3124.08

Rat NT-4 (Neurotrophin 4) ELISA Kit

EKE62213-96T 96T
EUR 657.7

Rat Neurotrophin 4,NT-4 ELISA KIT

EKC39486-48T 48T
EUR 439.25

Rat Neurotrophin 4,NT-4 ELISA KIT

EKC39486-5x96T 5x96T
EUR 2980.63

Rat Neurotrophin 4,NT-4 ELISA KIT

EKC39486-96T 96T
EUR 627.5

Rat Neurotrophin 4,NT-4 ELISA Kit

SL0523Ra -
EUR 498

Rat Neurotrophin 4 (NT-4) ELISA Kit

RK06216 96T
EUR 280

Mouse Neurotrophin 4 (NT-4) CLIA Kit

abx197347-96tests 96 tests
EUR 990

Mouse Neurotrophin 4,NT-4 ELISA KIT

CN-02428M1 96T
EUR 529.2

Mouse Neurotrophin 4,NT-4 ELISA KIT

CN-02428M2 48T
EUR 349.2

Mouse Neurotrophin 4, NT-4 ELISA KIT

CSB-E04690m-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Mouse Neurotrophin 4, NT-4 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse Neurotrophin 4, NT-4 ELISA KIT

1-CSB-E04690m
  • EUR 813.60
  • EUR 5572.80
  • EUR 2960.40
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Mouse Neurotrophin 4, NT-4 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse NT-4(Neurotrophin 4) ELISA Kit

EM1243 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA ;Reacts with: Mus ;Sensitivity: 9.375pg/ml

Mouse Neurotrophin 4(NT-4)ELISA Kit

GA-E0098MS-48T 48T
EUR 403.2

Mouse Neurotrophin 4(NT-4)ELISA Kit

GA-E0098MS-96T 96T
EUR 640.8

Mouse Neurotrophin 4(NT-4)ELISA Kit

QY-E21081 96T
EUR 433.2

Mouse Neurotrophin 4,NT-4 ELISA KIT

YLA0637MO-48T 48T
EUR 465

Mouse Neurotrophin 4,NT-4 ELISA KIT

YLA0637MO-96T 96T
EUR 600

Mouse Neurotrophin 4,NT-4 ELISA Kit

SL0403Mo -
EUR 528

Mouse Neurotrophin 4 (NT-4) ELISA Kit

RK06215 96T
EUR 280

NNT1 Neurotrophin-1 Human Recombinant Protein

PROTQ9UBD9-1 Regular: 10ug
EUR 380.4
Description: Neurotrophin-1 Human Recombinant (28-225) produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 199 amino acids and having a molecular mass of 22kDa.;The NNT-1 is purified by proprietary chromatographic techniques.

Rabbit neurotrophin 4,NT-4 ELISA Kit

CN-00681R1 96T
EUR 536.4

Rabbit neurotrophin 4,NT-4 ELISA Kit

CN-00681R2 48T
EUR 355.2

Rabbit neurotrophin 4,NT-4 ELISA Kit

GA-E0149RB-48T 48T
EUR 391.2

Rabbit neurotrophin 4,NT-4 ELISA Kit

GA-E0149RB-96T 96T
EUR 628.8

Rabbit neurotrophin 4,NT-4 ELISA Kit

QY-E30150 96T
EUR 448.8

Rabbit neurotrophin 4,NT-4 ELISA Kit

SL0148Rb -
EUR 498

Recombinant Mouse Neurotrophin-3

7-01300 2µg Ask for price

Recombinant Mouse Neurotrophin-3

7-01301 10µg Ask for price

Recombinant Mouse Neurotrophin-3

7-01302 1mg Ask for price

Recombinant Neurotrophin 3 (NT3)

4-RPA106Hu01
  • EUR 582.34
  • EUR 279.60
  • EUR 1853.76
  • EUR 697.92
  • EUR 1275.84
  • EUR 465.60
  • EUR 4454.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Neurotrophin 3 expressed in: E.coli

Recombinant Neurotrophin 3 (NT3)

4-RPA106Hu02
  • EUR 582.34
  • EUR 279.60
  • EUR 1853.76
  • EUR 697.92
  • EUR 1275.84
  • EUR 465.60
  • EUR 4454.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Neurotrophin 3 expressed in: E.coli

Recombinant Neurotrophin 3 (NT3)

4-RPA106Ra01
  • EUR 614.59
  • EUR 288.00
  • EUR 1974.72
  • EUR 738.24
  • EUR 1356.48
  • EUR 487.20
  • EUR 4756.80
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Recombinant Neurotrophin 3 (NT3) expressed in: E.coli

Recombinant Neurotrophin 3 (NT3)

4-RPA106Ra02
  • EUR 485.57
  • EUR 253.20
  • EUR 1490.88
  • EUR 576.96
  • EUR 1033.92
  • EUR 400.80
  • EUR 3547.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Neurotrophin 3 expressed in: E.coli

Recombinant Neurotrophin 3 (NT3)

RPU43032-100ug 100ug
EUR 530.2

Recombinant Neurotrophin 3 (NT3)

RPU43032-1mg 1mg
EUR 2347.8

Recombinant Neurotrophin 3 (NT3)

RPU43032-50ug 50ug
EUR 425.7

Recombinant Neurotrophin 3 (NT3)

RPU43033-100ug 100ug
EUR 530.2

Recombinant Neurotrophin 3 (NT3)

RPU43033-1mg 1mg
EUR 2347.8

Recombinant Neurotrophin 3 (NT3)

RPU43033-50ug 50ug
EUR 425.7

Recombinant Neurotrophin 3 (NT3)

RPU55489-100ug 100ug
EUR 728.2

Recombinant Neurotrophin 3 (NT3)

RPU55489-1mg 1mg
EUR 2870.4

Recombinant Neurotrophin 3 (NT3)

RPU55489-50ug 50ug
EUR 441.6

Recombinant Neurotrophin 3 (NT3)

RPU56654-100ug 100ug
EUR 470.4

In parallel, serum BDNF levels and t-PA activity / plasmin were assessed before and after (1, 4 and 2 4 h) induced an ischemic stroke in mice. Our study showed higher serum BDNF levels and better neurological outcomes in the rt-PA-treated compared to non-treated patients. However, serum BDNF level does not predict the outcome of a blow when the entire cohort of stroke patients were analyzed.