Overview outlines the development of therapeutics based on DNA for the treatment of hearing loss, and in particular, considers the potential for utilizing the properties recombinant neurotrophins to improve hearing cochlea (spiral ganglion) survival of neurons and repair , This potential to reduce the spiral ganglion neuron death and indeed re-grow the auditory nerve fibers have been the subject of pre-clinical evaluation sufficient for decades with a view of increasing the neural interface with cochlear implants.

It provides the context for the discussion on the development of novel means of using a cochlear implant electrode arrays for gene electrotransfer. mesenchymal perilymphatic compartments that line the cochlea can be selectively transfected with the (naked) plasmid DNA using various – based gene electrotransfer, called ‘near-field of electroporation’. This technology is able to drive the expression of brain derived neurotrophic factor ( BDNF ) in a rabbit model trial hearing, causing the regrowth of peripheral spiral ganglion cell neurites toward mesenchymla, and thus be close to the cochlear implant electrodes in the scala tympani.

This was associated with functional improvement of the cochlear implant neural interface (lower the recruitment threshold of nerve and extended dynamic range, measured using electrically – Evoked auditory brain stem response). Basis for the near-field of electroporation efficiency arises from compression of the electric field is close to conspire against cochlear implant electrodes. The area close to the array with the highest field strength is closely related to the distribution of bioreporter cells (adherent Human embryonic kidney (HEK293)) revealed the reporter green fluorescent protein (GFP) gene electrotransfer following.

Neurotrophin gene augmentation by electrotransfer to improve cochlear implant hearing outcomes.
Neurotrophin gene augmentation by electrotransfer to improve cochlear implant hearing outcomes.

Optimizing the parameters of gene electrotransfer using a cell-based model is closely correlated with in vitro and in vivo gene delivery results cochlea. Migration of cochlear implant electrode array-based platform that gene electrotransfer to a clinical trial for neurotrophin the cochlear implant-based improvement is supported by the availability of regulatory compliant plasmid backbone DNA mini-new (pFAR 4 ;. Free of antibiotic resistance plasmids v 4 ) that can be used to package ‘ human to materialize’ neurotrophin expression cassette.

A reporter cassette packed into pFAR 4 produced by expression of GFP prominent in the basal turn of guinea pig scalae perilymphatic. More broadly, the near-field of gene electrotransfer may lend itself to a spectrum of potential applications of DNA therapeutic benefits of titratable, local, naked DNA delivery, for enlargement of genes, gene regulation targeted strategy, or gene substitution.
WST-1 test results revealed that compared with group / R EGD, the survival rate of cells was significantly higher in OGD / R group and lower MIF in OGD / R with ISO-1 group.

Recombinant Human Neurotrophin-4

7-01304 10µg Ask for price

Recombinant Human Neurotrophin-4

7-01305 1mg Ask for price

Recombinant Human Neurotrophin-4

cyt-626-10g 10µg
EUR 145

Recombinant Human Neurotrophin-4

cyt-626-1mg 1mg
EUR 4680

Recombinant Human Neurotrophin-4

cyt-626-2g 2µg
EUR 60

Human Neurotrophin-4 ELISA Kit

EK1291 96 tests
EUR 599

Human Neurotrophin-4 ELISA Kit

IHUNTF4KT each
EUR 702
Description: Human Neurotrophin-4 ELISA Kit

Neurotrophin-4, recombinant (Human)

033-30 10 μg
EUR 390.96

Neurotrophin-4 Human Recombinant

rAP-2701 Inquiry Ask for price

Neurotrophin-4

AP78386 1mg
EUR 2640

Neurotrophin-4

AP86255 1mg
EUR 2640

Neurotrophin-4

AP86709 1mg
EUR 2640

Human Neurotrophin 4 ELISA kit

E01A6160 96T
EUR 700
Description: ELISA

Human Neurotrophin 4 ELISA kit

E01N0019-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Neurotrophin 4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Neurotrophin 4 ELISA kit

E01N0019-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Neurotrophin 4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Neurotrophin 4 ELISA kit

E01N0019-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Neurotrophin 4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Neurotrophin 4 ELISA kit

E01N0107-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Neurotrophin 4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Neurotrophin 4 ELISA kit

E01N0107-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Neurotrophin 4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Neurotrophin 4 ELISA kit

E01N0107-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Neurotrophin 4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Neurotrophin 4 ELISA kit

55R-2076 96 tests
EUR 780
Description: ELISA Kit for detection of Neurotrophin 4 in the research laboratory

Human Neurotrophin 4 ELISA Kit

IHUNT4KT each
EUR 667
Description: Human Neurotrophin 4 ELISA Kit

Recombinant Human Neurotrophin-4 (NT-4)

HEOPP-1405 10ug Ask for price

Neurotrophin 4

E8ER1913-76 100ul
EUR 275
Description: Available in various conjugation types.

Human NT-4(Neurotrophin-4) ELISA Kit

EH0246 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 56.25pg/ml

Human Neurotrophin 4 (NT4) Protein

20-abx167127
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Neurotrophin 4 (NT4) Protein

abx167127-100g 100 µg
EUR 600

Human Neurotrophin 4 (NT4) Protein

abx167127-10g 10 µg
EUR 225

Human Neurotrophin 4 (NT4) Protein

abx167127-50g 50 µg
EUR 412.5

Recombinant Human Neurotrophin-4(NTF4)

AP72096 1mg
EUR 1978

Human Neurotrophin-3

90225-A 2 µg
EUR 130
Description: Recombinant NT-3 is a disulfide-linked homodimer protein consisting of two 120 amino acid residue subunits, and migrates as an approximately 27 kDa protein under non-reducing and as 14 kDa under reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Neurotrophin-3 mature chain was expressed in E. coli.

Human Neurotrophin-3

90225-B 10 µg
EUR 205
Description: Recombinant NT-3 is a disulfide-linked homodimer protein consisting of two 120 amino acid residue subunits, and migrates as an approximately 27 kDa protein under non-reducing and as 14 kDa under reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Neurotrophin-3 mature chain was expressed in E. coli.

Human Neurotrophin-3

GWB-B90EEB 0.01 mg Ask for price

Human Neurotrophin 4 (NTF4) Protein

20-abx262207
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  • 10 ug
  • 1 mg
  • 2 µg

Human Neurotrophin 4 (NTF4) Protein

abx262207-10mg 10 mg
EUR 325

Human Neurotrophin 4 (NTF4) Protein

abx262207-25mg 25 mg
EUR 5975

Human Neurotrophin 4 (NTF4) Protein

abx262207-5mg 5 mg
EUR 225

Human Neurotrophin 4 (NT-4) CLIA Kit

abx197346-96tests 96 tests
EUR 990

Human Neurotrophin 4,NT-4 ELISA KIT

201-12-1293 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Neurotrophin 4,NT-4 ELISA KIT

EKC34810-48T 48T
EUR 389.34

Human Neurotrophin 4,NT-4 ELISA KIT

EKC34810-5x96T 5x96T
EUR 2641.95

Human Neurotrophin 4,NT-4 ELISA KIT

EKC34810-96T 96T
EUR 556.2

Human Neurotrophin 4(NT-4) Elisa Kit

EK713201 96 Wells
EUR 0.33

Human Neurotrophin 4(NT-4) Elisa Kit

EK711240 96 Wells
EUR 0.15

Human Neurotrophin 4, NT-4 ELISA KIT

CSB-E04689h-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human Neurotrophin 4, NT-4 in samples from serum, plasma, cell culture supernates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Neurotrophin 4, NT-4 ELISA KIT

1-CSB-E04689h
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  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Neurotrophin 4, NT-4 in samples from serum, plasma, cell culture supernates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Neurotrophin 4,NT-4 ELISA KIT

CN-03258H1 96T
EUR 525.6

Human Neurotrophin 4,NT-4 ELISA KIT

CN-03258H2 48T
EUR 346.8

Human Neurotrophin 4(NT-4)ELISA Kit

GA-E1309HM-48T 48T
EUR 346.8

Human Neurotrophin 4(NT-4)ELISA Kit

GA-E1309HM-96T 96T
EUR 559.2

Human Neurotrophin 4 (NT-4) ELISA Kit

RK00316 96T
EUR 280

Human Neurotrophin 4(NT-4)ELISA Kit

QY-E01633 96T
EUR 433.2

Human Neurotrophin 4,NT-4 ELISA Kit

SL1266Hu 96 Tests
EUR 468

Human Neurotrophin 4,NT-4 ELISA KIT

YLA1767HU-48T 48T Ask for price

Human Neurotrophin 4,NT-4 ELISA KIT

YLA1767HU-96T 96T Ask for price

Human NT-4 -Neurotrophin 4- CLIA Kit

E-CL-H1172-24Tests 24 Tests
EUR 180
Description: Sandwich

Human NT-4 -Neurotrophin 4- CLIA Kit

E-CL-H1172-48Tests 48 Tests
EUR 546
Description: Sandwich

Human NT-4 -Neurotrophin 4- CLIA Kit

E-CL-H1172-96Tests 96 Tests
EUR 682
Description: Sandwich

Human NT-4 -Neurotrophin 4- CLIA Kit

E-CL-H1172-96Tests10 96 Tests *10
EUR 6820
Description: Sandwich

Human NT-4 -Neurotrophin 4- CLIA Kit

E-CL-H1172-96Tests5 96 Tests *5
EUR 3410
Description: Sandwich

Human NTF4/ Neurotrophin-4 ELISA Kit

E2816Hu 1 Kit
EUR 515
Description: NTF5,Neurotrophin-5,Neutrophic factor 4,NT-5

Human NTF4 / Neurotrophin-4 ELISA Kit

E0107h 96T
EUR 736

Human Neurotrophin 4 (NT4) CLIA Kit

20-abx491029
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human NT-4 (Neurotrophin 4) ELISA Kit

EKE61097-5x96T 5x96T
EUR 3124.08

Human NT-4 (Neurotrophin 4) ELISA Kit

EKE61097-96T 96T
EUR 657.7

Human NT-4(Neurotrophin 4) ELISA Kit

RE2814H-48wells 48 wells
EUR 116.55

Human NT-4(Neurotrophin 4) ELISA Kit

RE2814H-96wells 96 wells
EUR 161.55

Human Neurotrophin 4 (NT4) ELISA Kit

DLR-NT4-Hu 96T
EUR 422
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Neurotrophin 4 (NT4) ELISA Kit

DLR-NT4-Hu-48T 48T
EUR 574.8
Description: A sandwich quantitative ELISA assay kit for detection of Human Neurotrophin 4 (NT4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Neurotrophin 4 (NT4) ELISA Kit

DLR-NT4-Hu-96T 96T
EUR 745.2
Description: A sandwich quantitative ELISA assay kit for detection of Human Neurotrophin 4 (NT4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Neurotrophin 4 (NT4) ELISA Kit

DL-NT4-Hu 96T
EUR 402
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Neurotrophin 4 (NT4) ELISA Kit

EKL59532-5x96T 5x96T
EUR 3452.78

Human Neurotrophin 4 (NT4) ELISA Kit

EKL59532-96T 96T
EUR 726.9

Human Neurotrophin 4 (NT4) ELISA Kit

EKN47384-48T 48T
EUR 341.04

Human Neurotrophin 4 (NT4) ELISA Kit

EKN47384-5x96T 5x96T
EUR 2314.2

Human Neurotrophin 4 (NT4) ELISA Kit

EKN47384-96T 96T
EUR 487.2

Human Neurotrophin 4 (NT4) ELISA Kit

EK15837 96Т
EUR 768

Human Neurotrophin 4 (NT4) ELISA Kit

EKU06273-48T 48T
EUR 500.5

Human Neurotrophin 4 (NT4) ELISA Kit

EKU06273-5x96T 5x96T
EUR 3396.25

Human Neurotrophin 4 (NT4) ELISA Kit

EKU06273-96T 96T
EUR 715

Human Neurotrophin 4(NT4) ELISA Kit

NSL0402Hu 96 wells
EUR 468

Human Neurotrophin 4 ELISA Kit (NT4)

RK01969 96 Tests
EUR 625.2

Human Neurotrophin 4 (NT4) ELISA Kit

RDR-NT4-Hu-48T 48T
EUR 432.39
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Human Neurotrophin 4 (NT4) ELISA Kit

RDR-NT4-Hu-48Tests 48 Tests
EUR 600

Human Neurotrophin 4 (NT4) ELISA Kit

RDR-NT4-Hu-96T 96T
EUR 617.72
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Human Neurotrophin 4 (NT4) ELISA Kit

RDR-NT4-Hu-96Tests 96 Tests
EUR 830.4

Human Neurotrophin 4 (NT4) ELISA Kit

RD-NT4-Hu-48T 48T
EUR 411.8
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Human Neurotrophin 4 (NT4) ELISA Kit

RD-NT4-Hu-48Tests 48 Tests
EUR 573.6

Human Neurotrophin 4 (NT4) ELISA Kit

RD-NT4-Hu-96T 96T
EUR 588.3
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Human Neurotrophin 4 (NT4) ELISA Kit

RD-NT4-Hu-96Tests 96 Tests
EUR 794.4

Human Neurotrophin 4 (NT4) ELISA Kit

SEA107Hu-10x96wellstestplate 10x96-wells test plate
EUR 5128.02
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Neurotrophin 4 (NT4) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Neurotrophin 4 (NT4) ELISA Kit

SEA107Hu-1x48wellstestplate 1x48-wells test plate
EUR 527.48
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Neurotrophin 4 (NT4) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Neurotrophin 4 (NT4) ELISA Kit

SEA107Hu-1x96wellstestplate 1x96-wells test plate
EUR 702.12
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Neurotrophin 4 (NT4) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Neurotrophin 4 (NT4) ELISA Kit

SEA107Hu-5x96wellstestplate 5x96-wells test plate
EUR 2799.54
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Neurotrophin 4 (NT4) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Neurotrophin 4 (NT4) ELISA Kit

4-SEA107Hu
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  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Neurotrophin 4 (NT4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species.

Human Neurotrophin 4 (NTF4) CLIA Kit

abx197346-100l 100 µl Ask for price

Human Neurotrophin 4 (NTF4) CLIA Kit

abx197346-50l 50 µl
EUR 618.75

Human Neurotrophin 4 (NTF4) ELISA Kit

20-abx152512
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Neurotrophin 4 (NTF4) ELISA Kit

abx050177-96tests 96 tests
EUR 782.4

Human Neurotrophin 4 (NTF4) ELISA Kit

abx251825-96tests 96 tests
EUR 848.4

Human Neurotrophin 4 (NTF4) ELISA Kit

abx575476-96tests 96 tests
EUR 848.4

Human NT4(Neurotrophin 4) ELISA Kit

ELK2298-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human NT4. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human NT4. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human NT4, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human NT4 in the samples is then determined by comparing the OD of the samples to the standard curve.

Human NT4(Neurotrophin 4) ELISA Kit

ELK2298-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human NT4. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human NT4. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human NT4, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human NT4 in the samples is then determined by comparing the OD of the samples to the standard curve.

Human Neurotrophin 4, NT-4 GENLISA ELISA

KBH1292 1 x 96 wells
EUR 286

Human Neurotrophin 4, NT-4 GENLISA ELISA

KBH5768 1 x 96 wells
EUR 286

CLIA kit for Human NT-4 (Neurotrophin 4)

E-CL-H1172 1 plate of 96 wells
EUR 700.8
Description: A sandwich CLIA kit for quantitative measurement of Human NT-4 (Neurotrophin 4) in samples from Serum, Plasma, Cell supernatant

rec Neurotrophin-3 (human)

H-1726.0002 2.0µg
EUR 194.4

rec Neurotrophin-3 (human)

H-1726.0010 10.0µg
EUR 457.2

ELISA kit for Human NT-4 (Neurotrophin 4)

E-EL-H1897 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Human NT-4 (Neurotrophin 4) in samples from Serum, Plasma, Cell supernatant

NT-4 Neurotrophin-4 Human Recombinant Protein

PROTP34130 Regular: 10ug
EUR 380.4
Description: Neurotrophin-4 Human Recombinant produced in E.Coli is a noncovalently linked homodimer, non-glycosylated polypeptide chain containing 2 x 130 amino acids (81-210 amino acids) and having a total molecular mass of 28 kDa. ;The NT-4 is purified by proprietary chromatographic techniques.

Human Neurotrophin 4 (NT4) Protein (Active)

20-abx655787
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

NTF4 (untagged)-Human neurotrophin 4 (NTF4)

SC122741 10 µg Ask for price

Human Neurotrophin 4 (NT4) Protein (Active)

abx655787-100g 100 µg
EUR 4275

Nori® Human Neurotrophin 4 ELISA Kit

GR111502 96-well
EUR 461

Recombinant Human Neurotrophin-4 (NTF4), partial

CSB-EP016121HU1 1830 mg Ask for price

Human Neurotrophin-3 Protein

abx060815-10ug 10 ug
EUR 560.4

ELISA kit for Human NT4 (Neurotrophin 4)

ELK2298 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of Neurotrophin 4 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Neurotrophin 4 Antibody

GWB-7F8693 0.5 mg Ask for price

Neurotrophin 4 Antibody

R34057-100UG 100 ug
EUR 339.15
Description: Additional name(s) for this target protein: NT5 antibody, NTF4, neurotrophic factor 4, neurotrophic factor 5; NTF5

Rabbit anti human Neurotrophin-4 Antibody (FITC)

20-abx107622
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Rabbit anti human Neurotrophin-4 Antibody (FITC)

abx107622-100g 100 µg
EUR 362.5

Rabbit anti human Neurotrophin-4 Antibody (FITC)

abx107622-20g 20 µg
EUR 162.5

Western blot assay and immunocytochemistry results revealed that the expression levels of BDNF , Bcl2, and MAP2 are significantly higher, and the level of expression of Caspase-3 and Bax were significantly lowered in the group MIF than in OGD / R group. the level of expression of BDNF , Bcl2, and MAP2 significantly lowered, and the level of expression of Caspase-3 and Bax were significantly higher in group 1 than in the ISO / OGD group R. MIF administration promoted cell survival nerves and causes a high level of expression of BDNF , MAP2, and Bcl-2 (anti-apoptotic) and the low expression levels of Caspase-3 and Bax (pro-apoptotic) in OGD / R models. this re