Neuroinflammation play an important role in the pathogenesis of germinal matrix hemorrhage (GMH). neurotrophin – 4 (NT- 4 ) is a member of the neurotrophin family and interact with tropomyosin receptor kinase B (TrkB ). NT- 4 has been shown to provide the following neurological effects of cerebral ischemia. We aimed to determine the function of the nerves of NT- 4 -TrkB signaling, as well as the signaling cascade downstream of phosphatidylinositol-3-kinase (PI3K) / protein kinase B (Akt) / forkhead box protein O1 (FoxO1), the following GMH in neonatal rats.

GMH induced by intraparenchymal injection of bacterial collagenase (0.3 U) in P7 rat pup. A total of 163 pups were used in this study. Recombinant Human NT- 4 is given intranasally at 1 hour after injection of collagenase. Selective TrkB ANA-12 antagonist, selective PI3K inhibitor LY29 4 002, and FoxO1 activate CRISPR given intracerebroventricularly at 2 4 hours before NT- 4 treatment to investigate the underlying mechanisms. Short-term and long-term neurobehavioral assessment, immunofluorescence staining, Nissl’s staining and Western blot performed.

The expression of phosphorylated TrkB increased after GMH, reaching peak levels on day 3 after bleeding. TrkB receptors were observed in neurons, microglia, and astrocytes. Administration rh-NT- 4 induced phosphorylation of TrkB, the expression of PI3K and Akt phosphorylation. Meanwhile, the decrease in FoxO1 and IL-6 levels. Selective inhibition of TrkB / PI3K / Akt signaling in microglia increase expression levels FoxO1 and pro-inflammatory cytokines. FoxO1 activate CRISPR increased expression of IL-6, suggesting that perhaps FoxO1 potential inducer of pro-inflammatory factors.

These results demonstrate that the PI3K / Akt / FoxO1 downstream signaling pathways may TrkB activation. Rat pups treated with rh-NT- 4 performed better than vehicle-treated animals both short-term and long-term behavioral tests. These data indicate that rh-NT – 4 reducing the expression of pro-inflammatory cytokines, improve neurological function, attenuated neuroinflammation, and thus reduced post-hemorrhagic hydrocephalus after GMH by TrkB / PI3K / Akt / FoxO1 track. These results indicate that rh-NT- 4 could be a promising therapeutic strategy for repairing nerve inflammation and hydrocephalus after GMH or other similar brain injuries.

NT-<em>4</em> attenuates neuroinflammation via TrkB/PI3K/FoxO1 pathway after germinal matrix hemorrhage in neonatal rats.
NT-4 attenuates neuroinflammation via TrkB/PI3K/FoxO1 pathway after germinal matrix hemorrhage in neonatal rats.

Brain-derived neurotrophic factors mediate macrophage migration inhibitory factor to protect neurons against oxygen-glucose deficiency.

Macrophage migration inhibitory factor (MIF) is a chemokine that plays an important role in immune system function. Previous research suggests that MIF protect neurons under ischemic conditions. However, several studies reported on the role of MIF in nerve recovery after ischemic stroke. The purpose of this study is to identify the molecular mechanisms of neuroprotection mediated by MIF.

Recombinant Human NT-3/Neurotrophin-3 Protein

E40KMP1632 20ug
EUR 495

NT-3 Neurotrophin-3 Mouse Recombinant Protein

PROTP20181 Regular: 10ug
EUR 380.4
Description: Neurotrophin-3 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 119 amino acids and having a molecular mass of 13.6kDa. ;The NT-3 is purified by proprietary chromatographic techniques.

Recombinant Neurotrophin 4 (NT4)

4-RPA107Hu01
  • EUR 614.59
  • EUR 288.00
  • EUR 1974.72
  • EUR 738.24
  • EUR 1356.48
  • EUR 487.20
  • EUR 4756.80
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Neurotrophin 4 expressed in: E.coli

Recombinant Neurotrophin 4 (NT4)

4-RPA107Mu01
  • EUR 601.69
  • EUR 284.40
  • EUR 1926.34
  • EUR 722.11
  • EUR 1324.22
  • EUR 477.60
  • EUR 4635.84
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Neurotrophin 4 expressed in: E.coli

Recombinant Neurotrophin 4 (NT4)

RPU43034-100ug 100ug
EUR 552.2

Recombinant Neurotrophin 4 (NT4)

RPU43034-1mg 1mg
EUR 2446.6

Recombinant Neurotrophin 4 (NT4)

RPU43034-50ug 50ug
EUR 443.3

Recombinant Neurotrophin 4 (NT4)

RPU53898-100ug 100ug
EUR 566.5

Recombinant Neurotrophin 4 (NT4)

RPU53898-1mg 1mg
EUR 2511.6

Recombinant Neurotrophin 4 (NT4)

RPU53898-50ug 50ug
EUR 455.4

Recombinant Neurotrophin 4 (NT4)

RPU59108-100ug 100ug
EUR 1044.4

Recombinant Neurotrophin 4 (NT4)

RPU59108-1mg 1mg
EUR 4083.3

Recombinant Neurotrophin 4 (NT4)

RPU59108-50ug 50ug
EUR 652.6

Recombinant Neurotrophin 4 (NT4)

RPU56286-100ug 100ug
EUR 775.5

Recombinant Neurotrophin 4 (NT4)

RPU56286-1mg 1mg
EUR 3057.6

Recombinant Neurotrophin 4 (NT4)

RPU56286-50ug 50ug
EUR 470.4

Genorise® Recombinant Equine Neurotrophin-4 protein

GR104319 5 µg
EUR 285

Recombinant Human NT-3/Neurotrophin-3/NTF3 Protein, No Tag

E40KMH1479 20ug
EUR 495

NT-4, Neurotrophin-4, human

RC218-15 2ug
EUR 125.26

Genorise® recombinant Bovine Neurotrophin 4 protein

GR120051 5 µg
EUR 285

Genorise® recombinant Canine Neurotrophin 4 protein

GR122076 5 µg
EUR 285

Neurotrophin-3 Recombinant Protein

91-065 0.05 mg
EUR 821.4
Description: Neurotrophin-3 (NT-3) is a member of the NGF family of neurotrophic factors and is structurally related to beta -NGF, BDNF and NT-4. The NT3 cDNA encodes a 257 amino acid residue precursor protein with a signal peptide and a proprotein that are cleaved to yield the 119 amino acid residue mature NT3.The amino acid sequences of mature human, murine and rat NT-3 are identical. NT-3 selectively promotes the differentiation and survival of specific neuronal subpopulations in both the central as well as the peripheral nervous systems.

NNT1 Neurotrophin-1 Human Recombinant Protein

PROTQ9UBD9-1 Regular: 10ug
EUR 380.4
Description: Neurotrophin-1 Human Recombinant (28-225) produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 199 amino acids and having a molecular mass of 22kDa.;The NNT-1 is purified by proprietary chromatographic techniques.

Genorise® Recombinant feline Neurotrophin 3 (NT-3) protein

GR186035 5 mg
EUR 285

Genorise® recombinant Bovine Neurotrophin 3 (NT-3) protein

GR120050 5 µg
EUR 285

Genorise® recombinant Sheep Neurotrophin 4

GR123022 5 µg
EUR 285

Human NT-4(Neurotrophin-4) ELISA Kit

EH0246 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 56.25pg/ml

Human Neurotrophin-3 (Recombinant)

22060430-1 2 µg
EUR 146.42

Human Neurotrophin 4 (NT-4) CLIA Kit

abx197346-96tests 96 tests
EUR 990

Human Neurotrophin 4,NT-4 ELISA KIT

201-12-1293 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Neurotrophin 4,NT-4 ELISA KIT

CN-03258H1 96T
EUR 525.6

Human Neurotrophin 4,NT-4 ELISA KIT

CN-03258H2 48T
EUR 346.8

Human Neurotrophin 4, NT-4 ELISA KIT

CSB-E04689h-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human Neurotrophin 4, NT-4 in samples from serum, plasma, cell culture supernates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Neurotrophin 4, NT-4 ELISA KIT

1-CSB-E04689h
  • EUR 688.80
  • EUR 4815.60
  • EUR 2565.60
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Neurotrophin 4, NT-4 in samples from serum, plasma, cell culture supernates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Neurotrophin 4(NT-4)ELISA Kit

GA-E1309HM-48T 48T
EUR 346.8

Human Neurotrophin 4(NT-4)ELISA Kit

GA-E1309HM-96T 96T
EUR 559.2

Human Neurotrophin 4(NT-4)ELISA Kit

QY-E01633 96T
EUR 433.2

Human Neurotrophin 4,NT-4 ELISA KIT

YLA1767HU-48T 48T
EUR 435

Human Neurotrophin 4,NT-4 ELISA KIT

YLA1767HU-96T 96T
EUR 562.5

Human Neurotrophin 4,NT-4 ELISA KIT

EKC34810-48T 48T
EUR 389.34

Human Neurotrophin 4,NT-4 ELISA KIT

EKC34810-5x96T 5x96T
EUR 2641.95

Human Neurotrophin 4,NT-4 ELISA KIT

EKC34810-96T 96T
EUR 556.2

Human Neurotrophin 4,NT-4 ELISA Kit

SL1266Hu 96 Tests
EUR 468

Human Neurotrophin 4 (NT-4) ELISA Kit

RK00316 96T
EUR 280

Human Neurotrophin-3 Recombinant Protein Tag Free Lyophilized

IHUNT3RTFLY50UG each
EUR 988
Description: Human Neurotrophin-3 Recombinant Protein Tag Free Lyophilized

Human NT-4 (Neurotrophin 4) ELISA Kit

EKE61097-5x96T 5x96T
EUR 3124.08

Human NT-4 (Neurotrophin 4) ELISA Kit

EKE61097-96T 96T
EUR 657.7

Recombinant Human Neurotrophin-3

7-01294 2µg Ask for price

Recombinant Human Neurotrophin-3

7-01295 10µg Ask for price

Recombinant Human Neurotrophin-3

7-01296 1mg Ask for price

NT-4 (Neurotrophin-4) GMP, CF

PR15132CF 5 ug
EUR 732

Recombinant Human Neurotrophin-3/NT3

C079-10ug 10ug
EUR 242.4
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 250mM NaCl, pH 7.2.

Recombinant Human Neurotrophin-3/NT3

C079-1mg 1mg
EUR 2739.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 250mM NaCl, pH 7.2.

Recombinant Human Neurotrophin-3/NT3

C079-500ug 500ug
EUR 1910.4
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 250mM NaCl, pH 7.2.

Recombinant Human Neurotrophin-3/NT3

C079-50ug 50ug
EUR 595.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 250mM NaCl, pH 7.2.

CLIA kit for Human NT-4 (Neurotrophin 4)

E-CL-H1172 1 plate of 96 wells
EUR 700.8
Description: A sandwich CLIA kit for quantitative measurement of Human NT-4 (Neurotrophin 4) in samples from Serum, Plasma, Cell supernatant

Recombinant Human Neurotrophin-3 (NTF3)

RPC28729-100ug 100ug
EUR 528

Recombinant Human Neurotrophin-3 (NTF3)

RPC28729-1mg 1mg
EUR 2412.5

Recombinant Human Neurotrophin-3 (NTF3)

RPC28729-20ug 20ug
EUR 295.7

Recombinant Human Neurotrophin-3 (NTF3)

RPC27838-100ug 100ug
EUR 1463

Recombinant Human Neurotrophin-3 (NTF3)

RPC27838-1mg 1mg
EUR 6879.6

Recombinant Human Neurotrophin-3 (NTF3)

RPC27838-20ug 20ug
EUR 550

Recombinant Human Neurotrophin-3 (NTF3)

RPC28701-100ug 100ug
EUR 1170.4

Recombinant Human Neurotrophin-3 (NTF3)

RPC28701-1mg 1mg
EUR 3252

Recombinant Human Neurotrophin-3 (NTF3)

RPC28701-20ug 20ug
EUR 440

ELISA kit for Human NT-4 (Neurotrophin 4)

E-EL-H1897 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Human NT-4 (Neurotrophin 4) in samples from Serum, Plasma, Cell supernatant

Human Neurotrophin 4 (NT4) Protein

20-abx167127
  • EUR 861.60
  • EUR 343.20
  • EUR 2665.20
  • EUR 1028.40
  • EUR 610.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Neurotrophin 4 (NTF4) Protein

20-abx262207
  • EUR 393.60
  • EUR 6991.20
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Human recombinant Neurotrophins-3 (NT-3) purified protein

NT3-R02 2 ug
EUR 270

Human recombinant Neurotrophins-3 (NT-3) purified protein

NT3-R10 10 ug
EUR 489.6

Human recombinant Neurotrophins-3 (NT-3) purified protein

NT3-R100 100 ug
EUR 2690.4

Human recombinant Neurotrophins-3 (NT-3) purified protein

NT3-R1000 1 mg
EUR 9998.4

Recombinant Human Precursor Neurotrophin-3

7-01297 2µg Ask for price

Recombinant Human Precursor Neurotrophin-3

7-01298 10µg Ask for price

Recombinant Human Precursor Neurotrophin-3

7-01299 1mg Ask for price

Human Neurotrophin-4

90226-A 2 µg
EUR 130
Description: Recombinant NT-4 is a disulfide-linked homodimer protein consisting of two 131 amino acid residues, and migrates as an approximately 29 kDa protein under non-reducing and as 14 kDa under reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Neurotrophin-4 mature chain was expressed in E. coli.

Human Neurotrophin-4

90226-B 10 µg
EUR 205
Description: Recombinant NT-4 is a disulfide-linked homodimer protein consisting of two 131 amino acid residues, and migrates as an approximately 29 kDa protein under non-reducing and as 14 kDa under reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Neurotrophin-4 mature chain was expressed in E. coli.

Rat Neurotrophin 4 (NT-4) CLIA Kit

abx197348-96tests 96 tests
EUR 990

Human NT-4 / Neurotrophin-4 Protein, Tag Free, low endotoxin (MALS verified)

NT4-H5114 500ug
EUR 267.5
Description: Human NT-4, Tag Free (NT4-H5114) is expressed from E. coli cells. It contains AA Gly 81 - Ala 210 (Accession # P34130-1).

Genorise® Recombinant Equine Neurotrophin-3 protein

GR104318 5 µg
EUR 285

Rat Neurotrophin 4,NT-4 ELISA KIT

CN-01592R1 96T
EUR 556.8

Rat Neurotrophin 4,NT-4 ELISA KIT

CN-01592R2 48T
EUR 375.6

Rat Neurotrophin 4, NT-4 ELISA KIT

CSB-E04691r-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Rat Neurotrophin 4, NT-4 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Rat Neurotrophin 4, NT-4 ELISA KIT

1-CSB-E04691r
  • EUR 813.60
  • EUR 5572.80
  • EUR 2960.40
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Rat Neurotrophin 4, NT-4 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Rat NT-4(Neurotrophin 4) ELISA Kit

ER1201 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 18.75pg/ml

Rat Neurotrophin 4(NT-4)ELISA Kit

GA-E0552RT-48T 48T
EUR 380.4

Rat Neurotrophin 4(NT-4)ELISA Kit

GA-E0552RT-96T 96T
EUR 595.2

Rat Neurotrophin 4(NT-4)ELISA Kit

QY-E11100 96T
EUR 433.2

Rat Neurotrophin 4,NT-4 ELISA KIT

YLA1017RA-48T 48T
EUR 465

Rat Neurotrophin 4,NT-4 ELISA KIT

YLA1017RA-96T 96T
EUR 600

Rat NT-4 (Neurotrophin 4) ELISA Kit

EKE62213-5x96T 5x96T
EUR 3124.08

Rat NT-4 (Neurotrophin 4) ELISA Kit

EKE62213-96T 96T
EUR 657.7

Rat Neurotrophin 4,NT-4 ELISA KIT

EKC39486-48T 48T
EUR 439.25

Rat Neurotrophin 4,NT-4 ELISA KIT

EKC39486-5x96T 5x96T
EUR 2980.63

Rat Neurotrophin 4,NT-4 ELISA KIT

EKC39486-96T 96T
EUR 627.5

Rat Neurotrophin 4,NT-4 ELISA Kit

SL0523Ra -
EUR 498

Rat Neurotrophin 4 (NT-4) ELISA Kit

RK06216 96T
EUR 280

Recombinant Human NTF3/ Neurotrophin 3 Protein, Untagged, E.coli-10ug

QP1246-10ug 10ug
EUR 284.4

Recombinant Human NTF3/ Neurotrophin 3 Protein, Untagged, E.coli-1mg

QP1246-1mg 1mg
EUR 5942.4

Recombinant Human NTF3/ Neurotrophin 3 Protein, Untagged, E.coli-2ug

QP1246-2ug 2ug
EUR 163.2

Mouse Neurotrophin 4 (NT-4) CLIA Kit

abx197347-96tests 96 tests
EUR 990

Mouse Neurotrophin 4,NT-4 ELISA KIT

CN-02428M1 96T
EUR 529.2

Mouse Neurotrophin 4,NT-4 ELISA KIT

CN-02428M2 48T
EUR 349.2

Mouse Neurotrophin 4, NT-4 ELISA KIT

CSB-E04690m-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Mouse Neurotrophin 4, NT-4 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse Neurotrophin 4, NT-4 ELISA KIT

1-CSB-E04690m
  • EUR 813.60
  • EUR 5572.80
  • EUR 2960.40
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Mouse Neurotrophin 4, NT-4 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse NT-4(Neurotrophin 4) ELISA Kit

EM1243 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA ;Reacts with: Mus ;Sensitivity: 9.375pg/ml

Mouse Neurotrophin 4(NT-4)ELISA Kit

GA-E0098MS-48T 48T
EUR 403.2

Mouse Neurotrophin 4(NT-4)ELISA Kit

GA-E0098MS-96T 96T
EUR 640.8

Mouse Neurotrophin 4(NT-4)ELISA Kit

QY-E21081 96T
EUR 433.2

Mouse Neurotrophin 4,NT-4 ELISA KIT

YLA0637MO-48T 48T
EUR 465

Mouse Neurotrophin 4,NT-4 ELISA KIT

YLA0637MO-96T 96T
EUR 600

Mouse Neurotrophin 4,NT-4 ELISA Kit

SL0403Mo -
EUR 528

Mouse Neurotrophin 4 (NT-4) ELISA Kit

RK06215 96T
EUR 280

Recombinant Human NTF3/ Neurotrophin 3 Protein, Untagged, E.coli-100ug

QP1246-100ug 100ug
EUR 849.6

Recombinant Human NTF3/ Neurotrophin 3 Protein, Untagged, E.coli-500ug

QP1246-500ug 500ug
EUR 3645.6

Rabbit neurotrophin 4,NT-4 ELISA Kit

CN-00681R1 96T
EUR 536.4

Rabbit neurotrophin 4,NT-4 ELISA Kit

CN-00681R2 48T
EUR 355.2

Rabbit neurotrophin 4,NT-4 ELISA Kit

GA-E0149RB-48T 48T
EUR 391.2

Rabbit neurotrophin 4,NT-4 ELISA Kit

GA-E0149RB-96T 96T
EUR 628.8

Rabbit neurotrophin 4,NT-4 ELISA Kit

QY-E30150 96T
EUR 448.8

Human cell neuroblastoma incubated in a modified media Eagle Dulbecco under lack of oxygen-glucose (OGD) for 4 hours and then returned to the aerobic environment normal to reperfusion (OGD / R). 30 ng / mL MIF recombinant (30 ng / mL) or ISO-1 (MIF antagonist; 50 M) was administered to the Human neuroblastoma cells. Then the cell culture is assigned to one of four groups: control, OGD / R, OGD / R by MIF, OGD / R with ISO-1.