Neuroinflammation play an important role in the pathogenesis of germinal matrix hemorrhage (GMH). neurotrophin – 4 (NT- 4 ) is a member of the neurotrophin family and interact with tropomyosin receptor kinase B (TrkB ). NT- 4 has been shown to provide the following neurological effects of cerebral ischemia. We aimed to determine the function of the nerves of NT- 4 -TrkB signaling, as well as the signaling cascade downstream of phosphatidylinositol-3-kinase (PI3K) / protein kinase B (Akt) / forkhead box protein O1 (FoxO1), the following GMH in neonatal rats.

GMH induced by intraparenchymal injection of bacterial collagenase (0.3 U) in P7 rat pup. A total of 163 pups were used in this study. Recombinant Human NT- 4 is given intranasally at 1 hour after injection of collagenase. Selective TrkB ANA-12 antagonist, selective PI3K inhibitor LY29 4 002, and FoxO1 activate CRISPR given intracerebroventricularly at 2 4 hours before NT- 4 treatment to investigate the underlying mechanisms. Short-term and long-term neurobehavioral assessment, immunofluorescence staining, Nissl’s staining and Western blot performed.

The expression of phosphorylated TrkB increased after GMH, reaching peak levels on day 3 after bleeding. TrkB receptors were observed in neurons, microglia, and astrocytes. Administration rh-NT- 4 induced phosphorylation of TrkB, the expression of PI3K and Akt phosphorylation. Meanwhile, the decrease in FoxO1 and IL-6 levels. Selective inhibition of TrkB / PI3K / Akt signaling in microglia increase expression levels FoxO1 and pro-inflammatory cytokines. FoxO1 activate CRISPR increased expression of IL-6, suggesting that perhaps FoxO1 potential inducer of pro-inflammatory factors.

These results demonstrate that the PI3K / Akt / FoxO1 downstream signaling pathways may TrkB activation. Rat pups treated with rh-NT- 4 performed better than vehicle-treated animals both short-term and long-term behavioral tests. These data indicate that rh-NT – 4 reducing the expression of pro-inflammatory cytokines, improve neurological function, attenuated neuroinflammation, and thus reduced post-hemorrhagic hydrocephalus after GMH by TrkB / PI3K / Akt / FoxO1 track. These results indicate that rh-NT- 4 could be a promising therapeutic strategy for repairing nerve inflammation and hydrocephalus after GMH or other similar brain injuries.

NT-<em>4</em> attenuates neuroinflammation via TrkB/PI3K/FoxO1 pathway after germinal matrix hemorrhage in neonatal rats.
NT-4 attenuates neuroinflammation via TrkB/PI3K/FoxO1 pathway after germinal matrix hemorrhage in neonatal rats.

Brain-derived neurotrophic factors mediate macrophage migration inhibitory factor to protect neurons against oxygen-glucose deficiency.

Macrophage migration inhibitory factor (MIF) is a chemokine that plays an important role in immune system function. Previous research suggests that MIF protect neurons under ischemic conditions. However, several studies reported on the role of MIF in nerve recovery after ischemic stroke. The purpose of this study is to identify the molecular mechanisms of neuroprotection mediated by MIF.

Recombinant Human Neurotrophin-4 protein (NTF4)

MBS9423137-01mg 0.1mg
EUR 1925

Recombinant Human Neurotrophin-4 protein (NTF4)

MBS9423137-025mg 0.25mg
EUR 3385

Recombinant Human Neurotrophin-4 protein (NTF4)

MBS9423137-05mg 0.5mg
EUR 4375

Recombinant Human Neurotrophin-4 protein (NTF4)

MBS9423137-1mg 1mg
EUR 5920

Recombinant Human Neurotrophin-4 protein(NTF4) (Active)

AP73547 1mg
EUR 6829

Recombinant Human Neurotrophin-4 protein (NTF4) (Active)

CSB-AP002831HU 8451 mg Ask for price

Recombinant Human Neurotrophin-4 protein (NTF4) (Active)

MBS969401-001mg 0.01mg
EUR 355

Recombinant Human Neurotrophin-4 protein (NTF4) (Active)

MBS969401-01mg 0.1mg
EUR 1590

Recombinant Human Neurotrophin-4 protein (NTF4) (Active)

MBS969401-05mg 0.5mg
EUR 3395

Recombinant Human Neurotrophin-4 protein (NTF4) (Active)

MBS969401-5x05mg 5x0.5mg
EUR 15240

Neurotrophin-4, recombinant (Human)

033-30 10 μg
EUR 390.96

Recombinant Human Neurotrophin-4

AP60103 100ug
EUR 1554

Recombinant Human Neurotrophin-4

7-01303 2µg Ask for price

Recombinant Human Neurotrophin-4

7-01304 10µg Ask for price

Recombinant Human Neurotrophin-4

7-01305 1mg Ask for price

Recombinant human Neurotrophin-4

MBS1265588-005mg 0.05mg
EUR 260

Recombinant human Neurotrophin-4

MBS1265588-02mg 0.2mg
EUR 560

Recombinant human Neurotrophin-4

MBS1265588-05mg 0.5mg
EUR 875

Recombinant human Neurotrophin-4

MBS1265588-1mg 1mg
EUR 1325

Recombinant Human Neurotrophin-4

cyt-626-10g 10µg
EUR 145

Recombinant Human Neurotrophin-4

cyt-626-1mg 1mg
EUR 4680

Recombinant Human Neurotrophin-4

cyt-626-2g 2µg
EUR 60

Recombinant Human Neurotrophin-4

MBS9421885-002mg 0.02mg
EUR 285

Recombinant Human Neurotrophin-4

MBS9421885-01mg 0.1mg
EUR 470

Recombinant Human Neurotrophin-4

MBS9421885-1mg 1mg
EUR 1785

Recombinant Human Neurotrophin-4

MBS9421885-5x1mg 5x1mg
EUR 7885

Recombinant Human Neurotrophin-4

MBS143528-0002mg 0.002mg
EUR 240

Recombinant Human Neurotrophin-4

MBS143528-001mg 0.01mg
EUR 310

Recombinant Human Neurotrophin-4

MBS143528-1mg 1mg
EUR 4895

Recombinant Human Neurotrophin-4

MBS143528-5x1mg 5x1mg
EUR 21695

Recombinant Human Neurotrophin-4

MBS969766-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1045

Recombinant Human Neurotrophin-4

MBS969766-002mgEColi 0.02mg(E-Coli)
EUR 260

Recombinant Human Neurotrophin-4

MBS969766-002mgYeast 0.02mg(Yeast)
EUR 800

Recombinant Human Neurotrophin-4

MBS969766-01mgEColi 0.1mg(E-Coli)
EUR 410

Recombinant Human Neurotrophin-4

MBS969766-01mgYeast 0.1mg(Yeast)
EUR 935

Recombinant Human Neurotrophin-4

P1304-.01 10ug
EUR 272.8
Description: Peptides & Proteins|Recombinant Proteins

Recombinant Human Neurotrophin-4

P1304-.1 100ug
EUR 1560.8
Description: Peptides & Proteins|Recombinant Proteins

Recombinant Human Neurotrophin-4

P1304-.5 500ug
EUR 3503.2
Description: Peptides & Proteins|Recombinant Proteins

Neurotrophin-4 Human Recombinant

rAP-2701 Inquiry Ask for price

NT-3 Neurotrophin-3 Human Recombinant Protein

PROTP20783 Regular: 10ug
EUR 380.4
Description: Neurotrophin-3 Human Recombinant produced in E.Coli is a non-glycosylated and non-covalently linked homodimer, containing 2x119 amino acid chains, having a total Mw of 27.2 kDa.;The NT-3 is purified by proprietary chromatographic techniques.

Genorise® Recombinant feline Neurotrophin 4 (NT-4) protein

GR186036 5 mg
EUR 285

Recombinant Human NT-3/Neurotrophin-3 Protein

E40KMP1632 20ug
EUR 495

Recombinant Human NT-3/Neurotrophin-3 Protein

MBS9139929-005mg 0.05mg
EUR 500

Recombinant Human NT-3/Neurotrophin-3 Protein

MBS9139929-5x005mg 5x0.05mg
EUR 2075

Recombinant Human Neurotrophin-4(NTF4)

AP72096 1mg
EUR 1978

Recombinant Human Neurotrophin-4 (NTF4)

MBS955083-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1050

Recombinant Human Neurotrophin-4 (NTF4)

MBS955083-002mgEColi 0.02mg(E-Coli)
EUR 630

Recombinant Human Neurotrophin-4 (NTF4)

MBS955083-002mgYeast 0.02mg(Yeast)
EUR 800

Recombinant Human Neurotrophin-4 (NTF4)

MBS955083-01mgEColi 0.1mg(E-Coli)
EUR 730

Recombinant Human Neurotrophin-4 (NTF4)

MBS955083-01mgYeast 0.1mg(Yeast)
EUR 940

Recombinant Human Neurotrophin-3/NGF-2/NT-3 Protein

RP00496 10 μg
EUR 286

Recombinant Human NT-3/Neurotrophin-3 protein, No Tag

MBS1560886-005mg 0.05mg
EUR 320

Recombinant Human NT-3/Neurotrophin-3 protein, No Tag

MBS1560886-01mg 0.1mg
EUR 410

Recombinant Human NT-3/Neurotrophin-3 protein, No Tag

MBS1560886-5x01mg 5x0.1mg
EUR 1520

NT-4, Neurotrophin-4, human

RC218-15 2ug
EUR 125.26

Recombinant Human Neurotrophin-4 (NTF4), partial

CSB-EP016121HU1 1830 mg Ask for price

Recombinant Human NT-3/Neurotrophin-3/NTF3 Protein, No Tag

E40KMH1479 20ug
EUR 495

Neurotrophin 3 Protein, Human, Recombinant

MBS8120163-002mg 0.02mg
EUR 275

Neurotrophin 3 Protein, Human, Recombinant

MBS8120163-01mg 0.1mg
EUR 510

Neurotrophin 3 Protein, Human, Recombinant

MBS8120163-5x01mg 5x0.1mg
EUR 2135

Recombinant Human Neurotrophin-3/NT3 Protein

MBS2553006-001mg 0.01mg
EUR 220

Recombinant Human Neurotrophin-3/NT3 Protein

MBS2553006-005mg 0.05mg
EUR 505

Recombinant Human Neurotrophin-3/NT3 Protein

MBS2553006-5x005mg 5x0.05mg
EUR 2270

Genorise® Recombinant Equine Neurotrophin-4 protein

GR104319 5 µg
EUR 285

NNT1 Neurotrophin-1 Human Recombinant Protein

PROTQ9UBD9-1 Regular: 10ug
EUR 380.4
Description: Neurotrophin-1 Human Recombinant (28-225) produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 199 amino acids and having a molecular mass of 22kDa.;The NNT-1 is purified by proprietary chromatographic techniques.

NT-3 Neurotrophin-3 Mouse Recombinant Protein

PROTP20181 Regular: 10ug
EUR 380.4
Description: Neurotrophin-3 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 119 amino acids and having a molecular mass of 13.6kDa. ;The NT-3 is purified by proprietary chromatographic techniques.

Genorise® recombinant Bovine Neurotrophin 4 protein

GR120051 5 µg
EUR 285

Genorise® recombinant Canine Neurotrophin 4 protein

GR122076 5 µg
EUR 285

Recombinant Neurotrophin 4 (NT4)

RPU56286-100ug 100ug
EUR 775.5

Recombinant Neurotrophin 4 (NT4)

RPU56286-1mg 1mg
EUR 3057.6

Recombinant Neurotrophin 4 (NT4)

RPU56286-50ug 50ug
EUR 470.4

Recombinant Neurotrophin 4 (NT4)

RPU59108-100ug 100ug
EUR 1044.4

Recombinant Neurotrophin 4 (NT4)

RPU59108-1mg 1mg
EUR 4083.3

Recombinant Neurotrophin 4 (NT4)

RPU59108-50ug 50ug
EUR 652.6

Recombinant Neurotrophin 4 (NT4)

RPU53898-100ug 100ug
EUR 566.5

Recombinant Neurotrophin 4 (NT4)

RPU53898-1mg 1mg
EUR 2511.6

Recombinant Neurotrophin 4 (NT4)

RPU53898-50ug 50ug
EUR 455.4

Recombinant Neurotrophin 4 (NT4)

RPA107Hu01 10ug
EUR 184

Recombinant Neurotrophin 4 (NT4)

4-RPA107Hu01
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  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Neurotrophin 4 expressed in: E.coli

Recombinant Neurotrophin 4 (NT4)

RPA107Mu01 10ug
EUR 179

Recombinant Neurotrophin 4 (NT4)

4-RPA107Mu01
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  • 100 ug
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  • 1 mg
  • 200 ug
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  • 5 mg
Description: Recombinant Mouse Neurotrophin 4 expressed in: E.coli

Recombinant Neurotrophin 4 (NT4)

RPA107Ra01 10ug
EUR 196

Recombinant Neurotrophin 4 (NT4)

RPU43034-100ug 100ug
EUR 552.2

Recombinant Neurotrophin 4 (NT4)

RPU43034-1mg 1mg
EUR 2446.6

Recombinant Neurotrophin 4 (NT4)

RPU43034-50ug 50ug
EUR 443.3

Recombinant Neurotrophin 4 (NT4)

MBS2018323-001mg 0.01mg
EUR 170

Recombinant Neurotrophin 4 (NT4)

MBS2018323-005mg 0.05mg
EUR 305

Recombinant Neurotrophin 4 (NT4)

MBS2018323-01mg 0.1mg
EUR 470

Recombinant Neurotrophin 4 (NT4)

MBS2018323-02mg 0.2mg
EUR 570

Recombinant Neurotrophin 4 (NT4)

MBS2018323-05mg 0.5mg
EUR 1085

Recombinant Neurotrophin 4 (NT4)

MBS2030815-001mg 0.01mg
EUR 175

Recombinant Neurotrophin 4 (NT4)

MBS2030815-005mg 0.05mg
EUR 315

Recombinant Neurotrophin 4 (NT4)

MBS2030815-01mg 0.1mg
EUR 480

Recombinant Neurotrophin 4 (NT4)

MBS2030815-02mg 0.2mg
EUR 585

Recombinant Neurotrophin 4 (NT4)

MBS2030815-05mg 0.5mg
EUR 1110

Recombinant Neurotrophin 4 (NT4)

MBS2122557-001mg 0.01mg
EUR 180

Recombinant Neurotrophin 4 (NT4)

MBS2122557-005mg 0.05mg
EUR 330

Recombinant Neurotrophin 4 (NT4)

MBS2122557-01mg 0.1mg
EUR 505

Recombinant Neurotrophin 4 (NT4)

MBS2122557-02mg 0.2mg
EUR 620

Recombinant Neurotrophin 4 (NT4)

MBS2122557-05mg 0.5mg
EUR 1180

Human Neurotrophin 4 (NT4) Protein

20-abx167127
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Neurotrophin 4 (NT4) Protein

abx167127-100g 100 µg
EUR 600

Human Neurotrophin 4 (NT4) Protein

abx167127-10g 10 µg
EUR 225

Human Neurotrophin 4 (NT4) Protein

abx167127-50g 50 µg
EUR 412.5

Human Neurotrophin-4 (NT-4 ) ELISA Kit

MBS2610627-10x96StripWells 10x96-Strip-Wells
EUR 3040

Human Neurotrophin-4 (NT-4 ) ELISA Kit

MBS2610627-48StripWells 48-Strip-Wells
EUR 285

Human Neurotrophin-4 (NT-4 ) ELISA Kit

MBS2610627-5x96StripWells 5x96-Strip-Wells
EUR 1670

Human Neurotrophin-4 (NT-4 ) ELISA Kit

MBS2610627-96StripWells 96-Strip-Wells
EUR 405

Human Neurotrophin-4(NT-4 )ELISA kit

EIA07612h each
EUR 430

Human Neurotrophin 4 (NTF4) Protein

20-abx262207
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  • 10 ug
  • 1 mg
  • 2 µg

Human Neurotrophin 4 (NTF4) Protein

abx262207-10mg 10 mg
EUR 325

Human Neurotrophin 4 (NTF4) Protein

abx262207-25mg 25 mg
EUR 5975

Human Neurotrophin 4 (NTF4) Protein

abx262207-5mg 5 mg
EUR 225

Human NT-4(Neurotrophin-4) ELISA Kit

EH0246 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 56.25pg/ml

Recombinant Human Neurotrophin-3/NTF3 Protein (Active)

PKSH032803-10ug 10ug
EUR 178
Description: Human

Recombinant Human Neurotrophin-3/NTF3 Protein (Active)

PKSH032803-50ug 50ug
EUR 523
Description: Human

Human Neurotrophin 4 (NT-4) CLIA Kit

abx197346-96tests 96 tests
EUR 990

Human Neurotrophin 4,NT-4 ELISA KIT

EKC34810-48T 48T
EUR 389.34

Human Neurotrophin 4,NT-4 ELISA KIT

EKC34810-5x96T 5x96T
EUR 2641.95

Human Neurotrophin 4,NT-4 ELISA KIT

EKC34810-96T 96T
EUR 556.2

Human cell neuroblastoma incubated in a modified media Eagle Dulbecco under lack of oxygen-glucose (OGD) for 4 hours and then returned to the aerobic environment normal to reperfusion (OGD / R). 30 ng / mL MIF recombinant (30 ng / mL) or ISO-1 (MIF antagonist; 50 M) was administered to the Human neuroblastoma cells. Then the cell culture is assigned to one of four groups: control, OGD / R, OGD / R by MIF, OGD / R with ISO-1.